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Mammalian Phenotype (MP): impaired muscle contractility

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   muscle phenotype [MP:0005369] <2>(49|57) (54|37|28)
+ + 2:   abnormal muscle physiology [MP:0002106] <23>(25|33) (27|16|11)
+ 1:   abnormal muscle contractility [MP:0005620] <3>(12|15) (13|10|7)
0:   impaired muscle contractility [MP:0000738] <3>(12|14) (13|10|7)
- 1:   impaired smooth muscle contractility [MP:0000740] <3>(1|1) (1|1|0)
- 1:   decreased cardiac muscle contractility [MP:0005140] <1>(6|8) (7|3|3)
- 1:   impaired skeletal muscle contractility [MP:0002841](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SRF-like0.00006897Direct
Metal cation-transporting ATPase, ATP-binding domain N0.0001557Direct
Calcium ATPase, transduction domain A0.0002854Direct
Myosin rod fragments0.0003943Direct
Calcium ATPase, transmembrane domain M0.0004824Direct
IP3 receptor type 1 binding core, domain 20.0006227Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.000629Direct
Riboflavin synthase domain-like0.000629Direct
Inhibitor of apoptosis (IAP) repeat0.001186Inherited
Flavoproteins0.001186Inherited
Transducin (alpha subunit), insertion domain0.002476Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Calcium ATPase, transmembrane domain M0.000004787Direct
Meta-cation ATPase, catalytic domain P0.00002418Direct
L domain0.00003474Direct
Metal cation-transporting ATPase, ATP-binding domain N0.00003748Direct
Cytochrome p450 reductase N-terminal domain-like0.00004337Direct
SRF-like0.00004337Direct
NADPH-cytochrome p450 reductase-like0.0001705Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0001705Direct
Calcium ATPase, transduction domain A0.0002113Direct
Myosin rod fragments0.0002849Direct
Inhibitor of apoptosis (IAP) repeat0.0004212Direct
Transducin (alpha subunit), insertion domain0.001848Inherited
LIM domain0.003042Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SRF-like0.00003278Direct
Metal cation-transporting ATPase, ATP-binding domain N0.00007775Direct
Calcium ATPase, transduction domain A0.0001464Direct
Myosin rod fragments0.0002059Direct
Calcium ATPase, transmembrane domain M0.0002542Direct
IP3 receptor type 1 binding core, domain 20.0003311Direct
Riboflavin synthase domain-like0.0003353Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0003353Direct
Inhibitor of apoptosis (IAP) repeat0.0006526Direct
Flavoproteins0.0006526Direct
Transducin (alpha subunit), insertion domain0.001423Inherited
dsRNA-binding domain-like0.0152Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
100909,49899
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.000001563Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00002493Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.00002493Direct
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.00005467Direct
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.00007775Direct
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.0001322Direct
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.0003311Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0.0003311Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.001049Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    82109,100909,49899
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    90257,90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.000001582Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00002493Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.00007775Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.0001322Direct
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.0003311Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.001136Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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