SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal lung morphology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   respiratory system phenotype [MP:0005388] <2>(33|46) (36|29|15)
+ 1:   abnormal respiratory system morphology [MP:0002132] <12>(22|34) (27|22|13)
0:   abnormal lung morphology [MP:0001175] <18>(15|25) (17|18|12)
- 1:   abnormal lung development [MP:0001176] <10>(3|6) (5|3|5)
- 1:   abnormal lung lobe morphology [MP:0010975] <7>(2|2) (2|2|3)
- 1:   abnormal lung epithelium morphology [MP:0006382] <6>(2|1) (2|1|0)
- 1:   abnormal right lung morphology [MP:0009570] <6>(2|2) (2|2|3)
- 1:   abnormal lung position or orientation [MP:0010853] <3>(0|0) (0|0|0)
- 1:   abnormal lung size [MP:0004881] <3>(0|3) (0|2|1)
- 1:   abnormal lung vasculature morphology [MP:0004007] <3>(4|4) (4|0|0)
- 1:   abnormal respiratory conducting tube morphology [MP:0004391] <3>(2|3) (3|3|2)
- 1:   abnormal pulmonary alveolar system morphology [MP:0010899] <2>(3|7) (3|10|5)
- 1:   abnormal left lung morphology [MP:0009569] <1>(0|0) (0|0|0)
- 1:   abnormal lung interstitium morphology [MP:0002276] <1>(0|0) (0|0|0)
- 1:   pulmonary fibrosis [MP:0006050] <1>(1|1) (1|1|0)
- 1:   pulmonary necrosis [MP:0010857] <1>(0|0) (0|0|0)
- 1:   abnormal pulmonary collagen fibril morphology [MP:0011641](0|0) (0|0|0)
- 1:   abnormal pulmonary elastic fiber morphology [MP:0003209](0|0) (0|0|0)
- 1:   absent lungs [MP:0001181](0|0) (0|0|0)
- 1:   lung cysts [MP:0004880](0|0) (0|0|0)
- 1:   pale lung [MP:0010887](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Growth factor receptor domain0.00000009612Direct
Kringle-like0.0001877Direct
Flavoproteins0.0005962Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0007085Direct
Riboflavin synthase domain-like0.0007085Direct
PGBD-like0.2205Inherited
Hemopexin-like domain0.2205Inherited
FnI-like domain0.2468Inherited
Integrin domains0.2842Inherited
TNF receptor-like0.3679Inherited
Integrin alpha N-terminal domain0.3679Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3844Inherited
Nuclear receptor ligand-binding domain0.5575Inherited
PH domain-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
RUNT domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Growth factor receptor domain0.000008365Direct
Extracellular domain of cell surface receptors0.00001855Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0000339Direct
NADPH-cytochrome p450 reductase-like0.0000339Direct
Short-chain cytokines0.0001596Direct
Erythroid transcription factor GATA-10.0008978Direct
L domain0.005256Inherited
EGF-type module0.01896Inherited
Hemopexin-like domain0.1908Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.1908Inherited
LIM domain0.1908Inherited
MMP N-terminal domain0.1908Inherited
Matrix metalloproteases, catalytic domain0.1908Inherited
Phosphotyrosine-binding domain (PTB)0.2421Inherited
Integrin domains0.2517Inherited
TNF receptor-like0.3335Inherited
Integrin alpha N-terminal domain0.3335Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.3335Inherited
Protein kinases, catalytic subunit0.3775Inherited
Nuclear receptor ligand-binding domain0.5261Inherited
Nuclear receptor0.5261Inherited
Forkhead DNA-binding domain0.6844Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Growth factor receptor domain0.00000003792Direct
Kringle-like0.00009443Direct
Flavoproteins0.0003164Direct
Riboflavin synthase domain-like0.0003793Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0003793Direct
EGF/Laminin0.0106Inherited
Hemopexin-like domain0.1823Inherited
PGBD-like0.1823Inherited
FnI-like domain0.2068Inherited
Integrin domains0.2418Inherited
Integrin alpha N-terminal domain0.3221Inherited
TNF receptor-like0.3221Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3381Inherited
Nuclear receptor ligand-binding domain0.5108Inherited
"Winged helix" DNA-binding domain0.956Inherited
PH domain-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.00008893Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0001954Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0002583Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0006828Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.000948Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001386Inherited
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.002227Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.004223Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.004223Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.00703Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1454Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1823Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.1823Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.2068Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.3213Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.3221Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.3221Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.3221Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0001092Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.000113Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0003164Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0003793Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.000948Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.001024Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.004223Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.04724Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.3221Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.3221Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.3221Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.5108Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)