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Mammalian Phenotype (MP): abnormal retina morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   vision/eye phenotype [MP:0005391] <2>(43|53) (50|27|17)
+ + + 3:   abnormal eye morphology [MP:0002092] <23>(39|49) (46|25|15)
+ + 2:   abnormal posterior eye segment morphology [MP:0005195] <4>(21|24) (23|14|8)
+ 1:   abnormal ocular fundus morphology [MP:0002864] <2>(19|23) (21|14|8)
0:   abnormal retina morphology [MP:0001325] <23>(19|23) (21|14|8)
- 1:   abnormal amacrine cell morphology [MP:0005240] <4>(3|4) (3|2|2)
- 1:   abnormal retinal vasculature morphology [MP:0002792] <4>(4|3) (4|3|1)
- 1:   abnormal retinal bipolar cell morphology [MP:0006073] <3>(1|4) (2|1|1)
- 1:   abnormal retinal layer morphology [MP:0003727] <3>(11|16) (12|8|6)
- 1:   abnormal total retina thickness [MP:0011963] <2>(0|0) (0|0|1)
- 1:   abnormal horizontal cell morphology [MP:0006068] <1>(1|1) (1|0|0)
- 1:   abnormal retinal development [MP:0009772] <1>(1|0) (1|0|1)
- 1:   retinal degeneration [MP:0001326] <1>(2|1) (2|0|0)
- 1:   retinal deposits [MP:0006187] <1>(0|0) (0|0|0)
- 1:   abnormal Muller cell morphology [MP:0005547](1|2) (1|1|1)
- 1:   abnormal retina inner limiting membrane morphology [MP:0010235](0|0) (0|0|0)
- 1:   abnormal retina outer limiting membrane morphology [MP:0010236](0|0) (0|0|0)
- 1:   absent retina [MP:0009773](0|0) (0|0|0)
- 1:   decreased susceptibility to induced retinal damage [MP:0003455](0|0) (0|0|0)
- 1:   decreased ventral retina size [MP:0010707](2|2) (2|1|0)
- 1:   retina coloboma [MP:0010715](0|0) (0|0|0)
- 1:   retina hyperplasia [MP:0001329](0|0) (0|0|0)
- 1:   retina hypoplasia [MP:0002984](1|1) (1|1|0)
- 1:   retinal detachment [MP:0003099](0|0) (1|0|0)
- 1:   retinal fibrosis [MP:0006186](0|0) (0|0|0)
- 1:   retinal gliosis [MP:0009392](0|0) (0|0|0)
- 1:   retinal hemorrhage [MP:0006185](0|0) (0|0|0)
- 1:   retinal spots [MP:0012671](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Plexin repeat0.000006807Direct
Notch domain0.00008181Direct
Sema domain0.00009324Direct
EGF/Laminin0.0005501Direct
HLH, helix-loop-helix DNA-binding domain0.002159Inherited
Nuclear receptor ligand-binding domain0.002228Inherited
GroEL equatorial domain-like0.002339Inherited
GAF domain-like0.005214Inherited
Cyclin-like0.005617Inherited
E2F-DP heterodimerization region0.009425Inherited
Clc chloride channel0.01494Inherited
CBS-domain pair0.01559Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.01745Inherited
Tetraspanin0.02612Inherited
TNF-like0.07191Inherited
PGBD-like0.1341Inherited
HD-domain/PDEase-like0.1502Inherited
Toll/Interleukin receptor TIR domain0.2199Inherited
Metalloproteases ("zincins"), catalytic domain0.2496Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
Plexin repeat0.000005178Direct
Notch domain0.00005073Direct
Sema domain0.00006755Direct
Nuclear receptor0.001255Inherited
Nuclear receptor ligand-binding domain0.00181Inherited
HLH, helix-loop-helix DNA-binding domain0.001935Inherited
GAF domain0.003741Inherited
E2F dimerization segment0.003741Inherited
CBS-domain pair0.008748Inherited
Laminin-type module0.0106Inherited
Clc chloride channel0.01129Inherited
YWTD domain0.01604Inherited
Cell cycle transcription factor e2f-dp0.01684Inherited
Extracellular domain of cell surface receptors0.02361Inherited
TNF-like0.06263Inherited
POU-specific domain0.1026Inherited
PDEase0.1026Inherited
MMP N-terminal domain0.1174Inherited
cAMP-binding domain0.1192Inherited
Cyclin0.1326Inherited
Matrix metalloproteases, catalytic domain0.1326Inherited
Calmodulin-like0.1444Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Plexin repeat0.000002929Direct
Notch domain0.00003921Direct
Sema domain0.00004477Direct
EGF/Laminin0.0002921Direct
HLH, helix-loop-helix DNA-binding domain0.001231Inherited
Nuclear receptor ligand-binding domain0.001273Inherited
GroEL equatorial domain-like0.001337Inherited
GAF domain-like0.003131Inherited
Cyclin-like0.003383Inherited
E2F-DP heterodimerization region0.005862Inherited
Clc chloride channel0.009587Inherited
CBS-domain pair0.01003Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.01137Inherited
YWTD domain0.01342Inherited
Tetraspanin0.01752Inherited
TNF-like0.05273Inherited
Growth factor receptor domain0.09163Inherited
PGBD-like0.1048Inherited
HD-domain/PDEase-like0.1189Inherited
Toll/Interleukin receptor TIR domain0.1817Inherited
Metalloproteases ("zincins"), catalytic domain0.2094Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.00000976Direct
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.00004477Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0001246Direct
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.0002763Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0003719Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0004148Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.003131Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.003131Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.005862Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.005862Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.02226Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.1048Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.1339Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.000001845Direct
    101288,50156,50044
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0.0003719Direct
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.0004068Direct
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.00166Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.003131Inherited
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.009587Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.01752Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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