SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal skeleton physiology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   skeleton phenotype [MP:0005390] <2>(46|63) (50|41|26)
0:   abnormal skeleton physiology [MP:0001533] <12>(17|20) (18|12|6)
- 1:   abnormal bone ossification [MP:0008271] <10>(8|11) (8|1|2)
- 1:   abnormal bone strength [MP:0001542] <5>(0|0) (0|0|0)
- 1:   abnormal bone remodeling [MP:0002998] <4>(3|6) (4|4|3)
- 1:   joint inflammation [MP:0002933] <4>(6|6) (6|5|0)
- 1:   abnormal bone stiffness [MP:0013636] <2>(0|1) (0|0|0)
- 1:   abnormal chondrocyte physiology [MP:0009780] <2>(0|0) (0|0|0)
- 1:   abnormal tendon stiffness [MP:0003097] <1>(1|1) (1|0|0)
- 1:   abnormal bone healing [MP:0002999](0|0) (0|0|0)
- 1:   abnormal joint mobility [MP:0008069](0|0) (0|0|0)
- 1:   bone necrosis [MP:0020225](0|0) (0|0|0)
- 1:   enthesitis [MP:0013942](0|0) (0|0|0)
- 1:   osteomyelitis [MP:0005190](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Integrin beta tail domain0.000766Direct
Kringle-like0.001346Inherited
TNF-like0.001933Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.006922Inherited
Riboflavin synthase domain-like0.006922Inherited
Flavoproteins0.008306Inherited
PGBD-like0.01501Inherited
Metalloproteases ("zincins"), catalytic domain0.01575Inherited
Leucine zipper domain0.01785Inherited
Spermadhesin, CUB domain0.019Inherited
Hemopexin-like domain0.03504Inherited
Toll/Interleukin receptor TIR domain0.08769Inherited
TB module/8-cys domain0.1231Inherited
FnI-like domain0.1333Inherited
L domain-like0.2234Inherited
Growth factor receptor domain0.2934Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
RUNT domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0.0003791Direct
Integrin beta tail domain0.0004938Direct
TNF-like0.001217Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001366Inherited
NADPH-cytochrome p450 reductase-like0.001366Inherited
MMP N-terminal domain0.01048Inherited
Matrix metalloproteases, catalytic domain0.01048Inherited
Leucine zipper domain0.01278Inherited
Spermadhesin, CUB domain0.01349Inherited
Hemopexin-like domain0.02561Inherited
EGF-type module0.04063Inherited
Toll/Interleukin receptor TIR domain0.06404Inherited
Extracellular domain of cell surface receptors0.09713Inherited
TB module/8-cys domain0.09952Inherited
TNF receptor-like0.1577Inherited
Transforming growth factor (TGF)-beta0.1716Inherited
Ngr ectodomain-like0.2462Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Integrin beta tail domain0.0004119Direct
Kringle-like0.000749Direct
TNF-like0.001097Inherited
Riboflavin synthase domain-like0.004234Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.004234Inherited
Flavoproteins0.005128Inherited
PGBD-like0.009633Inherited
Metalloproteases ("zincins"), catalytic domain0.01015Inherited
Leucine zipper domain0.01163Inherited
Spermadhesin, CUB domain0.0124Inherited
Hemopexin-like domain0.02411Inherited
Toll/Interleukin receptor TIR domain0.06535Inherited
TB module/8-cys domain0.09513Inherited
FnI-like domain0.1041Inherited
TNF receptor-like0.1517Inherited
L domain-like0.185Inherited
Growth factor receptor domain0.2505Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.0004119Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0004119Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0008812Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.008479Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.009633Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.01482Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0182Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.03578Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.03578Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.03578Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1705Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0004119Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.03578Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03578Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.09513Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2611Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)