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Mammalian Phenotype (MP): abnormal hematopoietic system physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
0:   abnormal hematopoietic system physiology [MP:0001545] <5>(39|53) (40|38|21)
- 1:   abnormal thymus physiology [MP:0003763] <4>(1|2) (1|1|0)
- 1:   abnormal blood cell physiology [MP:0012382] <3>(38|53) (39|38|21)
- 1:   abnormal hematopoietic stem cell physiology [MP:0010763] <2>(0|0) (0|0|0)
- 1:   abnormal splenocyte physiology [MP:0009333] <2>(1|2) (1|0|0)
- 1:   abnormal bone marrow cell physiology [MP:0009278] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
Immunoglobulin0.0000002364Direct
DEATH domain0.000002239Direct
SH2 domain0.00001714Direct
Toll/Interleukin receptor TIR domain0.00008356Direct
Caspase-like0.00008556Direct
p53-like transcription factors0.0003734Direct
Inhibitor of apoptosis (IAP) repeat0.003611Inherited
SH3-domain0.004087Inherited
TNF receptor-like0.01197Inherited
Integrin alpha N-terminal domain0.01342Inherited
TNF-like0.01361Inherited
PH domain-like0.01711Inherited
Integrin domains0.02574Inherited
Family A G protein-coupled receptor-like0.03408Inherited
Bcl-2 inhibitors of programmed cell death0.03485Inherited
DBL homology domain (DH-domain)0.04321Inherited
C-type lectin-like0.05199Inherited
Cysteine-rich domain0.0645Inherited
MHC antigen-recognition domain0.07234Inherited
4-helical cytokines0.0908Inherited
A DNA-binding domain in eukaryotic transcription factors0.102Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1324Inherited
SMAD/FHA domain0.1514Inherited
Interleukin 8-like chemokines0.1737Inherited
vWA-like0.1888Inherited
E set domains0.1889Inherited
WWE domain0.1966Inherited
PLC-like phosphodiesterases0.2042Inherited
Transducin (alpha subunit), insertion domain0.2591Inherited
Integrin beta tail domain0.2828Inherited
Complement control module/SCR domain0.3665Inherited
Flavoproteins0.3886Inherited
L30e-like0.5619Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.5868Inherited
EGF/Laminin0.686Inherited
L domain-like0.8615Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Cysteine rich domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Proteasome subunits0Direct
STAT DNA-binding domain0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
SH2 domain0.00001664Direct
Caspase recruitment domain, CARD0.00004387Direct
Toll/Interleukin receptor TIR domain0.0001025Direct
Caspase catalytic domain0.0002112Direct
Inhibitor of apoptosis (IAP) repeat0.0006178Direct
Interferon regulatory factor0.002257Inherited
Pleckstrin-homology domain (PH domain)0.002285Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.002629Inherited
DEATH domain, DD0.002936Inherited
SH3-domain0.004037Inherited
V set domains (antibody variable domain-like)0.004717Inherited
C-type lectin domain0.004717Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.006521Inherited
TNF receptor-like0.00726Inherited
Cytochrome p450 reductase N-terminal domain-like0.008737Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.01067Inherited
TNF-like0.01121Inherited
Integrin alpha N-terminal domain0.0117Inherited
I set domains0.01396Inherited
PLC-like (P variant)0.01619Inherited
Short-chain cytokines0.01726Inherited
Rhodopsin-like0.01786Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.01958Inherited
Integrin domains0.02117Inherited
NADPH-cytochrome p450 reductase-like0.02603Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02603Inherited
Bcl-2 inhibitors of programmed cell death0.02754Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.03945Inherited
DBL homology domain (DH-domain)0.04005Inherited
Pyrin domain, PYD0.04415Inherited
C1 set domains (antibody constant domain-like)0.04638Inherited
MHC antigen-recognition domain0.06329Inherited
Mammalian PLC0.07024Inherited
A DNA-binding domain in eukaryotic transcription factors0.08705Inherited
28-residue LRR0.09091Inherited
Integrin A (or I) domain0.1273Inherited
Interleukin 8-like chemokines0.1604Inherited
ets domain0.163Inherited
WWE domain0.1724Inherited
Transducin (alpha subunit), insertion domain0.2369Inherited
Integrin beta tail domain0.2585Inherited
Integrin beta EGF-like domains0.2585Inherited
Complement control module/SCR domain0.3502Inherited
Interleukin 17F, IL-17F0.3622Inherited
FHA domain0.522Inherited
EGF-type module0.744Inherited
G proteins0.976Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
Immunoglobulin0.00000009461Direct
DEATH domain0.0000009321Direct
SH2 domain0.000007637Direct
Toll/Interleukin receptor TIR domain0.00004014Direct
Caspase-like0.00004114Direct
p53-like transcription factors0.0001946Direct
Inhibitor of apoptosis (IAP) repeat0.002118Inherited
SH3-domain0.002411Inherited
TNF receptor-like0.007579Inherited
Integrin alpha N-terminal domain0.008553Inherited
TNF-like0.008692Inherited
PH domain-like0.01111Inherited
Integrin domains0.01725Inherited
Family A G protein-coupled receptor-like0.0234Inherited
Bcl-2 inhibitors of programmed cell death0.02396Inherited
DBL homology domain (DH-domain)0.03016Inherited
C-type lectin-like0.0368Inherited
Cysteine-rich domain0.04681Inherited
MHC antigen-recognition domain0.05307Inherited
4-helical cytokines0.06784Inherited
A DNA-binding domain in eukaryotic transcription factors0.07718Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1032Inherited
SMAD/FHA domain0.12Inherited
Interleukin 8-like chemokines0.1394Inherited
vWA-like0.1531Inherited
E set domains0.1533Inherited
WWE domain0.1602Inherited
PLC-like phosphodiesterases0.1671Inherited
Transducin (alpha subunit), insertion domain0.2181Inherited
Integrin beta tail domain0.2406Inherited
RNI-like0.2852Inherited
Complement control module/SCR domain0.3207Inherited
Flavoproteins0.3421Inherited
L30e-like0.5154Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.5407Inherited
EGF/Laminin0.6444Inherited
L domain-like0.8314Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    57440,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    50370,57440
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.000432Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0004906Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.0004906Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.002118Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.003197Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.005598Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.007433Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.008838Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.008838Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.008838Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.01147Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.02204Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.02273Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.02317Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.02396Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0389Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0389Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.04185Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.05005Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.06294Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.06294Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.06294Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.06294Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.1009Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1142Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1322Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.2406Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.2406Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3695Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    50370,57440,56436
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0Direct
    57440,56436,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.002118Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.005598Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.005906Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.008838Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.02273Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.02576Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1009Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.1009Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1142Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.2406Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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