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Mammalian Phenotype (MP): abnormal lipid level

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + 2:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ 1:   abnormal lipid homeostasis [MP:0002118] <9>(25|29) (29|17|10)
0:   abnormal lipid level [MP:0001547] <16>(24|28) (26|16|10)
- 1:   abnormal circulating lipid level [MP:0003949] <9>(16|23) (19|13|10)
- 1:   abnormal sterol level [MP:0012224] <5>(11|13) (14|10|8)
- 1:   abnormal sphingolipid level [MP:0012230] <4>(0|0) (0|0|0)
- 1:   abnormal fatty acid level [MP:0005280] <3>(3|3) (3|2|0)
- 1:   abnormal glycerol level [MP:0003439] <3>(2|1) (2|0|0)
- 1:   abnormal phospholipid level [MP:0004777] <3>(2|1) (2|1|0)
- 1:   abnormal triglyceride level [MP:0000187] <3>(9|14) (9|9|5)
- 1:   abnormal bile salt level [MP:0004774] <2>(1|2) (2|1|0)
- 1:   abnormal carcass lipid [MP:0020112] <2>(0|0) (0|0|0)
- 1:   abnormal corticosterone level [MP:0003963] <2>(1|1) (1|0|0)
- 1:   abnormal leukotriene level [MP:0009813] <2>(0|0) (0|0|0)
- 1:   abnormal prostaglandin level [MP:0009811] <2>(4|4) (4|0|0)
- 1:   abnormal thromboxane level [MP:0009818] <2>(0|0) (0|0|0)
- 1:   abnormal galactolipid level [MP:0020380](0|0) (0|0|0)
- 1:   abnormal sulfolipid level [MP:0020003](0|0) (0|0|0)
- 1:   lipidosis [MP:0008570](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Thioesterase/thiol ester dehydrase-isomerase0.00008299Direct
Flavoproteins0.0003822Direct
FAD-binding/transporter-associated domain-like0.0004949Direct
Apolipoprotein A-I0.0004949Direct
Aquaporin-like0.002115Inherited
ClpP/crotonase0.002341Inherited
DHS-like NAD/FAD-binding domain0.002341Inherited
STAT0.004617Inherited
Transcription factor STAT-4 N-domain0.004617Inherited
YWTD domain0.005597Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.00735Inherited
Riboflavin synthase domain-like0.00735Inherited
Serum albumin-like0.00859Inherited
Multidrug efflux transporter AcrB transmembrane domain0.008982Inherited
CAD & PB1 domains0.09126Inherited
alpha/beta-Hydrolases0.4314Inherited
Bet v1-like0.7193Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.7193Inherited
Family A G protein-coupled receptor-like0.8748Inherited
Nuclear receptor ligand-binding domain0.8768Inherited
Lipocalins0.9468Inherited
Cytochrome P4500.9721Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
HCDH C-domain-like0Direct
Apolipoprotein A-I0Direct
Sir2 family of transcriptional regulators0.0002344Direct
Cytochrome b50.0002344Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0003014Direct
NADPH-cytochrome p450 reductase-like0.0003014Direct
Aquaporin-like0.001416Inherited
Crotonase-like0.001762Inherited
STAT DNA-binding domain0.00313Inherited
STAT0.00313Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.00313Inherited
Transcription factor STAT-4 N-domain0.00313Inherited
YWTD domain0.003905Inherited
CAD domain0.00594Inherited
Serum albumin-like0.00594Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.01222Inherited
EGF-type module0.225Inherited
Nuclear receptor0.6566Inherited
ABC transporter transmembrane region0.7078Inherited
Fatty acid binding protein-like0.7078Inherited
ABC transporter ATPase domain-like0.7468Inherited
Pancreatic lipase, N-terminal domain0.7735Inherited
Nuclear receptor ligand-binding domain0.8444Inherited
Rhodopsin-like0.9055Inherited
Cytochrome P4500.956Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Thioesterase/thiol ester dehydrase-isomerase0.00003981Direct
Flavoproteins0.0001993Direct
Apolipoprotein A-I0.0002611Direct
FAD-binding/transporter-associated domain-like0.0002611Direct
Aquaporin-like0.001206Inherited
DHS-like NAD/FAD-binding domain0.001339Inherited
ClpP/crotonase0.001339Inherited
STAT0.002747Inherited
Transcription factor STAT-4 N-domain0.002747Inherited
YWTD domain0.003369Inherited
Riboflavin synthase domain-like0.004514Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.004514Inherited
Serum albumin-like0.00531Inherited
Multidrug efflux transporter AcrB transmembrane domain0.005561Inherited
CAD & PB1 domains0.0683Inherited
alpha/beta-Hydrolases0.3844Inherited
ABC transporter transmembrane region0.6795Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.6795Inherited
Bet v1-like0.6795Inherited
P-loop containing nucleoside triphosphate hydrolases0.8305Inherited
Family A G protein-coupled receptor-like0.8458Inherited
Nuclear receptor ligand-binding domain0.8479Inherited
Lipocalins0.9248Inherited
Cytochrome P4500.9534Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.001339Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.001544Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.002747Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.002747Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.002747Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.002747Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.002747Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.002747Inherited
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.00531Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.009692Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.6795Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.7748Inherited
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0.8093Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.8238Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.0009563Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.001072Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.001072Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.001072Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.002747Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.002747Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.002747Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.01159Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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