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Mammalian Phenotype (MP): abnormal homeostasis

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
0:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
- 1:   abnormal urine homeostasis [MP:0009643] <38>(9|7) (13|3|0)
- 1:   abnormal blood homeostasis [MP:0009642] <23>(63|82) (70|45|21)
- 1:   abnormal enzyme/coenzyme level [MP:0005319] <22>(7|9) (10|3|0)
- 1:   abnormal hormone level [MP:0003953] <15>(27|29) (30|17|8)
- 1:   abnormal ion homeostasis [MP:0001765] <15>(9|12) (11|4|0)
- 1:   abnormal protein level [MP:0008469] <15>(23|31) (25|13|3)
- 1:   abnormal glucose homeostasis [MP:0002078] <14>(15|22) (17|17|8)
- 1:   abnormal fluid regulation [MP:0001784] <13>(9|17) (10|9|4)
- 1:   abnormal lipid homeostasis [MP:0002118] <9>(25|29) (29|17|10)
- 1:   abnormal gas homeostasis [MP:0003948] <7>(10|9) (11|2|2)
- 1:   abnormal amino acid level [MP:0005332] <5>(8|9) (9|2|0)
- 1:   abnormal catecholamine level [MP:0011479] <4>(4|3) (4|2|0)
- 1:   abnormal mineral homeostasis [MP:0005636] <4>(5|6) (5|1|0)
- 1:   abnormal adaptive thermogenesis [MP:0011019] <3>(6|6) (6|4|2)
- 1:   abnormal pH regulation [MP:0004043] <3>(2|2) (2|0|0)
- 1:   abnormal susceptibility to non-insulin-dependent diabetes [MP:0020086] <3>(0|0) (0|0|0)
- 1:   abnormal vitamin homeostasis [MP:0004019] <3>(3|3) (3|0|0)
- 1:   abnormal body temperature [MP:0005535] <2>(1|0) (1|0|0)
- 1:   abnormal body temperature homeostasis [MP:0001777] <2>(3|3) (3|0|0)
- 1:   abnormal glycosaminoglycan level [MP:0011475] <2>(2|1) (2|0|0)
- 1:   abnormal porphyrin level [MP:0011989] <2>(0|0) (0|0|0)
- 1:   abnormal energy homeostasis [MP:0005448] <1>(4|5) (6|4|1)
- 1:   abnormal lipoprotein level [MP:0010329] <1>(7|8) (8|4|4)
- 1:   photosensitivity [MP:0001999] <1>(0|0) (0|0|0)
- 1:   abnormal galactose homeostasis [MP:0004018](0|0) (0|0|0)
- 1:   abnormal histamine physiology [MP:0002503](0|0) (0|0|0)
- 1:   phototoxicity [MP:0005653](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Metallothionein0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Radical SAM enzymes0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
p53 tetramerization domain0Direct
GLA-domain0Direct
FAS1 domain0Direct
Lamin A/C globular tail domain0Direct
Ammonium transporter0Direct
Lipoxigenase0Direct
HMA, heavy metal-associated domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Notch domain0Direct
Hormone receptor domain0.0004016Direct
PLP-dependent transferases0.006067Inherited
Acyl-CoA dehydrogenase NM domain-like0.006368Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.006368Inherited
MFS general substrate transporter0.007831Inherited
Aquaporin-like0.008046Inherited
Glycerol-3-phosphate (1)-acyltransferase0.008046Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.01163Inherited
SMAD MH1 domain0.01189Inherited
STAT0.02164Inherited
Transcription factor STAT-4 N-domain0.02164Inherited
Thioesterase/thiol ester dehydrase-isomerase0.0391Inherited
KA1-like0.0391Inherited
DHS-like NAD/FAD-binding domain0.04028Inherited
Insulin-like0.04028Inherited
C-type lectin-like0.04435Inherited
SNF-like0.04554Inherited
Nuclear receptor ligand-binding domain0.05388Inherited
Family A G protein-coupled receptor-like0.05643Inherited
Serum albumin-like0.06922Inherited
Nuclear receptor coactivator interlocking domain0.06922Inherited
FAD-binding/transporter-associated domain-like0.06922Inherited
Apolipoprotein A-I0.06922Inherited
ACT-like0.06922Inherited
Transducin (alpha subunit), insertion domain0.08003Inherited
Galactose mutarotase-like0.1069Inherited
SH2 domain0.1211Inherited
Triple coiled coil domain of C-type lectins0.1212Inherited
ClpP/crotonase0.1321Inherited
Clathrin adaptor appendage domain0.1321Inherited
GAT-like domain0.1685Inherited
Cation efflux protein transmembrane domain-like0.1685Inherited
(Trans)glycosidases0.1887Inherited
PYP-like sensor domain (PAS domain)0.1887Inherited
p53-like transcription factors0.1983Inherited
GroEL equatorial domain-like0.2594Inherited
Integrin domains0.2814Inherited
Lipocalins0.2814Inherited
Alkaline phosphatase-like0.3062Inherited
4-helical cytokines0.3094Inherited
Cystine-knot cytokines0.3296Inherited
Toll/Interleukin receptor TIR domain0.3316Inherited
E set domains0.3708Inherited
HMG-box0.3728Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3801Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.3965Inherited
Riboflavin synthase domain-like0.4219Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4219Inherited
Bet v1-like0.4219Inherited
PH domain-like0.4449Inherited
CBS-domain pair0.4584Inherited
DEATH domain0.4618Inherited
Carbonic anhydrase0.4904Inherited
Phoshotransferase/anion transport protein0.5382Inherited
YWTD domain0.5382Inherited
Glycosyl hydrolase domain0.5382Inherited
Actin-like ATPase domain0.5571Inherited
Flavoproteins0.5833Inherited
Growth factor receptor domain0.6148Inherited
TNF receptor-like0.6203Inherited
Thioredoxin-like0.6213Inherited
Clc chloride channel0.6323Inherited
Multidrug efflux transporter AcrB transmembrane domain0.6323Inherited
LDL receptor-like module0.6389Inherited
Heme-dependent peroxidases0.6851Inherited
HLH, helix-loop-helix DNA-binding domain0.694Inherited
Homeodomain-like0.7348Inherited
CCCH zinc finger0.783Inherited
CAD & PB1 domains0.7887Inherited
Cytochrome P4500.7948Inherited
FAD/NAD(P)-binding domain0.7952Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.7965Inherited
Thyroglobulin type-1 domain0.8152Inherited
EGF/Laminin0.8257Inherited
alpha/beta-Hydrolases0.8299Inherited
Kringle-like0.8456Inherited
Caspase-like0.8572Inherited
PLC-like phosphodiesterases0.8572Inherited
Cyclin-like0.8603Inherited
NAD(P)-binding Rossmann-fold domains0.8628Inherited
Intermediate filament protein, coiled coil region0.878Inherited
Inhibitor of apoptosis (IAP) repeat0.9224Inherited
Fibronectin type III0.9236Inherited
Protein kinase-like (PK-like)0.9243Inherited
Cytokine0.9624Inherited
Trypsin-like serine proteases0.9928Inherited
ENTH/VHS domain0.9938Inherited
Immunoglobulin1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Anaphylotoxins (complement system)0Direct
Neurolysin-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
p53 DNA-binding domain-like0Direct
IP3 receptor type 1 binding core, domain 20Direct
Notch domain0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Animal lipoxigenases0Direct
Multidomain cupredoxins0Direct
NADPH-cytochrome p450 reductase-like0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
FAS1 domain0Direct
RUNT domain0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Carboxylesterase0Direct
Choline/Carnitine O-acyltransferase0Direct
HCDH C-domain-like0Direct
Sir2 family of transcriptional regulators0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Neurotrophin0Direct
GLA-domain0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
Cytidylyltransferase0Direct
p53 tetramerization domain0Direct
Metallothionein0Direct
Ammonium transporter0Direct
gamma-adaptin C-terminal appendage domain-like0Direct
Serum paraoxonase/arylesterase 1, PON10Direct
Retinoblastoma tumor suppressor domains0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Apolipoprotein A-I0Direct
HMA, heavy metal-associated domain0Direct
Phenylalanine metabolism regulatory domain0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
Erythroid transcription factor GATA-10Direct
Hormone receptor domain0.0003055Direct
Short-chain cytokines0.0003433Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0003433Direct
GABA-aminotransferase-like0.004859Inherited
Aquaporin-like0.006361Inherited
SMAD MH1 domain0.0092Inherited
SMAD domain0.0092Inherited
STAT DNA-binding domain0.01706Inherited
Transcription factor STAT-4 N-domain0.01706Inherited
L domain0.01706Inherited
STAT0.01706Inherited
Pancreatic lipase, N-terminal domain0.01706Inherited
Fatty acid binding protein-like0.02473Inherited
Lipoxigenase N-terminal domain0.03125Inherited
C-type lectin domain0.03246Inherited
Insulin-like0.03306Inherited
SNF-like0.03886Inherited
Nuclear receptor ligand-binding domain0.03909Inherited
Nuclear receptor0.04729Inherited
Nuclear receptor coactivator interlocking domain0.05714Inherited
Serum albumin-like0.05714Inherited
Transducin (alpha subunit), insertion domain0.07071Inherited
Rhodopsin-like0.07193Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.09235Inherited
Pyrin domain, PYD0.09235Inherited
Crotonase-like0.1033Inherited
GAT domain0.1033Inherited
beta-glycanases0.1033Inherited
Kinase associated domain 1, KA10.1033Inherited
Triple coiled coil domain of C-type lectins0.1033Inherited
Acetyl-CoA synthetase-like0.1132Inherited
Interferon regulatory factor0.117Inherited
SH2 domain0.1313Inherited
EGF-type module0.146Inherited
Noncollagenous (NC1) domain of collagen IV0.1489Inherited
E2F dimerization segment0.1489Inherited
Cation efflux protein transmembrane domain-like0.1489Inherited
Phosphotyrosine-binding domain (PTB)0.1518Inherited
28-residue LRR0.2222Inherited
Integrin domains0.2426Inherited
Chaperone J-domain0.2838Inherited
Toll/Interleukin receptor TIR domain0.3178Inherited
TNF receptor-like0.3481Inherited
T-box0.3481Inherited
Forkhead DNA-binding domain0.3754Inherited
HMG-box0.3754Inherited
Meta-cation ATPase, catalytic domain P0.3791Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.3791Inherited
Transforming growth factor (TGF)-beta0.3815Inherited
Pleckstrin-homology domain (PH domain)0.3945Inherited
PLC-like (P variant)0.4012Inherited
CBS-domain pair0.4156Inherited
Growth factor receptor domain0.4469Inherited
Carbonic anhydrase0.4767Inherited
YWTD domain0.4968Inherited
Arylsulfatase0.5008Inherited
Interferons/interleukin-10 (IL-10)0.5008Inherited
VHS domain0.5136Inherited
Mammalian PLC0.5414Inherited
Platelet-derived growth factor-like0.5414Inherited
Papain-like0.5414Inherited
Anion transport protein, cytoplasmic domain0.5414Inherited
ABC transporter transmembrane region0.5456Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.5666Inherited
Clc chloride channel0.5927Inherited
Cytochrome b50.5927Inherited
LDL receptor-like module0.5979Inherited
Pointed domain0.6476Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.6476Inherited
Interleukin-1 (IL-1)0.6476Inherited
Myeloperoxidase-like0.6476Inherited
p120GAP domain-like0.6476Inherited
Homeodomain0.6728Inherited
ABC transporter ATPase domain-like0.6811Inherited
CAD domain0.7076Inherited
HLH, helix-loop-helix DNA-binding domain0.7246Inherited
G proteins0.7253Inherited
DEATH domain, DD0.7352Inherited
Long-chain cytokines0.7563Inherited
Cytochrome P4500.7618Inherited
CCCH zinc finger0.7731Inherited
Thyroglobulin type-1 domain0.8077Inherited
Caspase catalytic domain0.8309Inherited
Caspase recruitment domain, CARD0.8309Inherited
Intermediate filament protein, coiled coil region0.8832Inherited
Inhibitor of apoptosis (IAP) repeat0.9022Inherited
Fibronectin type III0.912Inherited
Cyclin0.9548Inherited
Kringle modules0.9565Inherited
Eukaryotic proteases0.9667Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Lipoxigenase0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Radical SAM enzymes0Direct
Metallothionein0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
HMA, heavy metal-associated domain0Direct
Notch domain0Direct
FAS1 domain0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
p53 tetramerization domain0Direct
GLA-domain0Direct
Lamin A/C globular tail domain0Direct
Ammonium transporter0Direct
Anaphylotoxins (complement system)0Direct
Hormone receptor domain0.0002097Direct
PLP-dependent transferases0.003669Inherited
Acyl-CoA dehydrogenase NM domain-like0.003875Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.003875Inherited
MFS general substrate transporter0.004809Inherited
Aquaporin-like0.004954Inherited
Glycerol-3-phosphate (1)-acyltransferase0.004954Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.007355Inherited
SMAD MH1 domain0.007528Inherited
STAT0.01429Inherited
Transcription factor STAT-4 N-domain0.01429Inherited
KA1-like0.02706Inherited
Thioesterase/thiol ester dehydrase-isomerase0.02706Inherited
DHS-like NAD/FAD-binding domain0.028Inherited
Insulin-like0.028Inherited
C-type lectin-like0.03103Inherited
SNF-like0.03196Inherited
Nuclear receptor ligand-binding domain0.03829Inherited
Family A G protein-coupled receptor-like0.04034Inherited
Serum albumin-like0.0506Inherited
ACT-like0.0506Inherited
Nuclear receptor coactivator interlocking domain0.0506Inherited
Apolipoprotein A-I0.0506Inherited
FAD-binding/transporter-associated domain-like0.0506Inherited
Transducin (alpha subunit), insertion domain0.05909Inherited
Galactose mutarotase-like0.08138Inherited
SH2 domain0.09343Inherited
Triple coiled coil domain of C-type lectins0.09346Inherited
Acetyl-CoA synthetase-like0.09657Inherited
Clathrin adaptor appendage domain0.103Inherited
ClpP/crotonase0.103Inherited
Cation efflux protein transmembrane domain-like0.1348Inherited
GAT-like domain0.1348Inherited
(Trans)glycosidases0.153Inherited
PYP-like sensor domain (PAS domain)0.153Inherited
p53-like transcription factors0.1616Inherited
t-snare proteins0.1749Inherited
GroEL equatorial domain-like0.2184Inherited
Lipocalins0.2393Inherited
Integrin domains0.2393Inherited
E2F-DP heterodimerization region0.2405Inherited
Chaperone J-domain0.2446Inherited
Alkaline phosphatase-like0.2627Inherited
4-helical cytokines0.2656Inherited
Cystine-knot cytokines0.285Inherited
Toll/Interleukin receptor TIR domain0.287Inherited
E set domains0.3249Inherited
HMG-box0.3269Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.3339Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.35Inherited
Bet v1-like0.3751Inherited
Riboflavin synthase domain-like0.3751Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.3751Inherited
PH domain-like0.3973Inherited
CBS-domain pair0.4106Inherited
DEATH domain0.4141Inherited
Carbonic anhydrase0.4427Inherited
ABC transporter transmembrane region0.4802Inherited
YWTD domain0.4912Inherited
Phoshotransferase/anion transport protein0.4912Inherited
Glycosyl hydrolase domain0.4912Inherited
Actin-like ATPase domain0.5104Inherited
Flavoproteins0.537Inherited
Growth factor receptor domain0.5696Inherited
TNF receptor-like0.5753Inherited
Thioredoxin-like0.5764Inherited
Multidrug efflux transporter AcrB transmembrane domain0.588Inherited
Clc chloride channel0.588Inherited
Phospholipase A2, PLA20.588Inherited
LDL receptor-like module0.5947Inherited
Heme-dependent peroxidases0.6434Inherited
HLH, helix-loop-helix DNA-binding domain0.6528Inherited
Homeodomain-like0.696Inherited
TNF-like0.7402Inherited
CCCH zinc finger0.7472Inherited
CAD & PB1 domains0.7532Inherited
Cytochrome P4500.7598Inherited
FAD/NAD(P)-binding domain0.7602Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.7615Inherited
Thyroglobulin type-1 domain0.7813Inherited
EGF/Laminin0.7928Inherited
alpha/beta-Hydrolases0.7973Inherited
Kringle-like0.8141Inherited
Caspase-like0.8266Inherited
PLC-like phosphodiesterases0.8266Inherited
Cyclin-like0.8301Inherited
NAD(P)-binding Rossmann-fold domains0.8328Inherited
Intermediate filament protein, coiled coil region0.8492Inherited
Inhibitor of apoptosis (IAP) repeat0.8976Inherited
Fibronectin type III0.8989Inherited
Protein kinase-like (PK-like)0.8997Inherited
FnI-like domain0.9121Inherited
Cytokine0.9424Inherited
P-loop containing nucleoside triphosphate hydrolases0.9664Inherited
Trypsin-like serine proteases0.9783Inherited
ENTH/VHS domain0.9794Inherited
SMAD/FHA domain0.9988Inherited
Immunoglobulin1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    48403,50044
  • 48403 - Ankyrin repeat
  • 50044 - SH3-domain
  • 0Direct
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57196,50494
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0Direct
    46565,57938
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 0Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    48452,57850
  • 48452 - TPR-like
  • 57850 - RING/U-box
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.003875Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.003875Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.007355Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01429Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.01429Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.01429Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01429Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.01429Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01429Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.02706Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.04832Inherited
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.0506Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.08134Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.08138Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08831Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.09346Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.103Inherited
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.1348Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.1348Inherited
    47769,47769
  • 47769 - SAM/Pointed domain
  • 47769 - SAM/Pointed domain
  • 0.1348Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.1396Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.1593Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.1593Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.1749Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.2405Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.287Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.3174Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.3541Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3557Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.363Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.4106Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.4744Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.4802Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.4912Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.5138Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.5416Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.588Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.588Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.588Inherited
    81324,81324
  • 81324 - Voltage-gated potassium channels
  • 81324 - Voltage-gated potassium channels
  • 0.6434Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.6812Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.703Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.8171Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.8976Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.9121Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.9818Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    46565,57938,49493
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01429Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01429Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.01429Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01442Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.02706Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.02706Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.02706Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.04014Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.09346Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1294Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.1348Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.1348Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1593Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.2184Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.2405Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.3137Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.6441Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.703Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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