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Mammalian Phenotype (MP): abnormal immune system physiology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
0:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
- 1:   abnormal adaptive immunity [MP:0002420] <8>(36|48) (38|33|21)
- 1:   abnormal antigen presentation [MP:0001835] <6>(7|8) (7|4|2)
- 1:   abnormal innate immunity [MP:0002419] <5>(17|15) (18|9|5)
- 1:   abnormal humoral immune response [MP:0001800] <4>(10|14) (12|10|8)
- 1:   abnormal hypersensitivity reaction [MP:0002148] <4>(1|2) (1|1|0)
- 1:   abnormal immune organ physiology [MP:0003762] <4>(3|5) (3|1|0)
- 1:   abnormal immune serum protein physiology [MP:0002723] <4>(25|40) (32|24|12)
- 1:   abnormal inflammatory response [MP:0001845] <4>(27|38) (29|18|5)
- 1:   abnormal response to transplant [MP:0005671] <4>(2|2) (2|0|0)
- 1:   abnormal cell-mediated immunity [MP:0002421] <3>(35|48) (37|33|21)
- 1:   abnormal immune cell physiology [MP:0001819] <3>(35|48) (37|33|21)
- 1:   abnormal immune tolerance [MP:0005000] <3>(11|19) (13|8|1)
- 1:   abnormal lymphatic system physiology [MP:0010368] <2>(0|0) (0|0|0)
- 1:   abnormal response to antigen [MP:0020000] <2>(0|0) (0|0|0)
- 1:   abnormal response to infection [MP:0005025] <2>(18|31) (21|17|5)
- 1:   abnormal immunoglobulin transcytosis [MP:0010223](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Resistin0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
p53 tetramerization domain0Direct
Toll/Interleukin receptor TIR domain0.000000000003094Direct
Immunoglobulin0.00001561Direct
DEATH domain0.00009773Direct
Caspase-like0.000113Direct
C-type lectin-like0.0001147Direct
TNF-like0.000279Direct
Alpha-macroglobulin receptor domain0.001475Inherited
Inhibitor of apoptosis (IAP) repeat0.001475Inherited
p53-like transcription factors0.002552Inherited
SH3-domain0.003964Inherited
SH2 domain0.00916Inherited
Family A G protein-coupled receptor-like0.0102Inherited
4-helical cytokines0.01027Inherited
TNF receptor-like0.01894Inherited
Fibronectin type III0.02113Inherited
Kringle-like0.02842Inherited
Triple coiled coil domain of C-type lectins0.03014Inherited
Transducin (alpha subunit), insertion domain0.03516Inherited
Hemopexin-like domain0.0616Inherited
PGBD-like0.0616Inherited
SMAD/FHA domain0.06362Inherited
WWE domain0.06983Inherited
Trypsin-like serine proteases0.09217Inherited
E set domains0.09345Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1197Inherited
Riboflavin synthase domain-like0.135Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.135Inherited
vWA-like0.1455Inherited
L domain-like0.147Inherited
Interleukin 8-like chemokines0.1479Inherited
Integrin alpha N-terminal domain0.1712Inherited
Cysteine-rich domain0.1834Inherited
Bcl-2 inhibitors of programmed cell death0.1855Inherited
DBL homology domain (DH-domain)0.1876Inherited
Integrin domains0.2018Inherited
MHC antigen-recognition domain0.2018Inherited
Integrin beta tail domain0.2297Inherited
Complement control module/SCR domain0.3701Inherited
RNI-like0.4165Inherited
EGF/Laminin0.4224Inherited
Terpenoid cyclases/Protein prenyltransferases0.4633Inherited
dsRNA-binding domain-like0.4633Inherited
Nuclear receptor ligand-binding domain0.493Inherited
Growth factor receptor domain0.6176Inherited
DNA/RNA polymerases0.6631Inherited
Flavoproteins0.7079Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.733Inherited
Cystine-knot cytokines0.7401Inherited
CCCH zinc finger0.8691Inherited
L30e-like0.8691Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9358Inherited
Nicotinic receptor ligand binding domain-like0.9358Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Cysteine rich domain0Direct
p53 DNA-binding domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Proteasome subunits0Direct
STAT DNA-binding domain0Direct
Interleukin-1 (IL-1)0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
p53 tetramerization domain0Direct
Interleukin 17F, IL-17F0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Resistin0Direct
Toll/Interleukin receptor TIR domain0.00000000001054Direct
TNF receptor-like0.00000002492Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00003699Direct
Interferon regulatory factor0.0001156Direct
Caspase recruitment domain, CARD0.0001403Direct
Caspase catalytic domain0.0002311Direct
TNF-like0.0002428Direct
DEATH domain, DD0.0004761Direct
C-type lectin domain0.0005266Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0008924Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0.001049Inherited
Complement components0.001049Inherited
Alpha-macroglobulin receptor domain0.001049Inherited
Interferons/interleukin-10 (IL-10)0.001734Inherited
Inhibitor of apoptosis (IAP) repeat0.003065Inherited
SH3-domain0.00375Inherited
Rhodopsin-like0.008347Inherited
SH2 domain0.008586Inherited
PLC-like (P variant)0.009302Inherited
C2 set domains0.01199Inherited
Triple coiled coil domain of C-type lectins0.02349Inherited
Cytochrome p450 reductase N-terminal domain-like0.02349Inherited
Fibronectin type III0.02492Inherited
V set domains (antibody variable domain-like)0.02698Inherited
WWE domain0.02774Inherited
Transducin (alpha subunit), insertion domain0.02964Inherited
I set domains0.04549Inherited
Short-chain cytokines0.05116Inherited
MMP N-terminal domain0.05116Inherited
Hemopexin-like domain0.05116Inherited
Matrix metalloproteases, catalytic domain0.05116Inherited
Pleckstrin-homology domain (PH domain)0.05159Inherited
EF-hand modules in multidomain proteins0.06427Inherited
NADPH-cytochrome p450 reductase-like0.06482Inherited
Netrin-like domain (NTR/C345C module)0.06482Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.06482Inherited
Fibronectin type II module0.08185Inherited
Integrin A (or I) domain0.0867Inherited
Papain-like0.09751Inherited
Eukaryotic proteases0.09763Inherited
28-residue LRR0.1038Inherited
Noncollagenous (NC1) domain of collagen IV0.1206Inherited
Kringle modules0.1327Inherited
Interleukin 8-like chemokines0.1339Inherited
C1 set domains (antibody constant domain-like)0.158Inherited
VWC domain0.1642Inherited
Bcl-2 inhibitors of programmed cell death0.1642Inherited
Long-chain cytokines0.1642Inherited
DBL homology domain (DH-domain)0.1852Inherited
MHC antigen-recognition domain0.1856Inherited
Integrin domains0.1856Inherited
Integrin beta tail domain0.2063Inherited
Integrin beta EGF-like domains0.2063Inherited
Pyrin domain, PYD0.2063Inherited
Integrin alpha N-terminal domain0.2214Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2644Inherited
Ngr ectodomain-like0.2928Inherited
Complement control module/SCR domain0.3548Inherited
Double-stranded RNA-binding domain (dsRBD)0.39Inherited
Notch domain0.4082Inherited
Cell cycle control phosphatase, catalytic domain0.476Inherited
Nuclear receptor ligand-binding domain0.4853Inherited
Nuclear receptor0.4853Inherited
EGF-type module0.5976Inherited
FHA domain0.6354Inherited
RING finger domain, C3HC40.8331Inherited
CCCH zinc finger0.8567Inherited
Transforming growth factor (TGF)-beta0.8618Inherited
ets domain0.8951Inherited
Nicotinic receptor ligand binding domain-like0.9351Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9351Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
Resistin0Direct
p53 tetramerization domain0Direct
Anaphylotoxins (complement system)0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Transcription factor STAT-4 N-domain0Direct
Toll/Interleukin receptor TIR domain0.000000000001117Direct
Immunoglobulin0.000006937Direct
DEATH domain0.0000472Direct
Caspase-like0.00005516Direct
C-type lectin-like0.00005609Direct
TNF-like0.0001431Direct
Alpha-macroglobulin receptor domain0.0008261Direct
Inhibitor of apoptosis (IAP) repeat0.0008261Direct
p53-like transcription factors0.001468Inherited
SH3-domain0.002337Inherited
SH2 domain0.00568Inherited
Family A G protein-coupled receptor-like0.00638Inherited
4-helical cytokines0.006429Inherited
TNF receptor-like0.01236Inherited
Fibronectin type III0.01392Inherited
Kringle-like0.01922Inherited
Triple coiled coil domain of C-type lectins0.0205Inherited
Transducin (alpha subunit), insertion domain0.02419Inherited
PGBD-like0.04449Inherited
Hemopexin-like domain0.04449Inherited
SMAD/FHA domain0.04611Inherited
WWE domain0.05105Inherited
Protein kinase-like (PK-like)0.05323Inherited
Trypsin-like serine proteases0.06904Inherited
E set domains0.07002Inherited
PH domain-like0.08761Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.09225Inherited
Riboflavin synthase domain-like0.1056Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1056Inherited
vWA-like0.1148Inherited
L domain-like0.116Inherited
Interleukin 8-like chemokines0.1167Inherited
Integrin alpha N-terminal domain0.1373Inherited
Cysteine-rich domain0.1484Inherited
Bcl-2 inhibitors of programmed cell death0.1502Inherited
DBL homology domain (DH-domain)0.152Inherited
Integrin domains0.1649Inherited
MHC antigen-recognition domain0.1649Inherited
Integrin beta tail domain0.1907Inherited
Complement control module/SCR domain0.3242Inherited
RNI-like0.3694Inherited
EGF/Laminin0.3756Inherited
Notch domain0.3889Inherited
Rhodanese/Cell cycle control phosphatase0.3974Inherited
dsRNA-binding domain-like0.4156Inherited
Terpenoid cyclases/Protein prenyltransferases0.4156Inherited
Nuclear receptor ligand-binding domain0.4453Inherited
Growth factor receptor domain0.5725Inherited
DNA/RNA polymerases0.6205Inherited
Flavoproteins0.6676Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.6941Inherited
Cystine-knot cytokines0.7016Inherited
RING/U-box0.8314Inherited
"Winged helix" DNA-binding domain0.8314Inherited
CCCH zinc finger0.8395Inherited
L30e-like0.8395Inherited
Cytokine0.879Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9126Inherited
Nicotinic receptor ligand binding domain-like0.9126Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    52047,52058
  • 52047 - RNI-like
  • 52058 - L domain-like
  • 0Direct
    90188,53649
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    57440,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    50370,57440
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 0Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000254Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.001137Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.002455Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.002475Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.003648Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.003648Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.007257Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.00974Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.0205Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.0205Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.02286Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.04449Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04611Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.04726Inherited
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.05105Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.08124Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.09286Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.1167Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.1502Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1788Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1907Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.1907Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.202Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.202Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.2414Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.269Inherited
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.3061Inherited
    52821,52799
  • 52821 - Rhodanese/Cell cycle control phosphatase
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.3065Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3638Inherited
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.3889Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3943Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.6676Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.7121Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.9126Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    57850,49599,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0Direct
    56436,56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    50370,57440,56436
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    90188,90188,53649
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0Direct
    57440,56436,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.007257Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.007257Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.007257Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.02286Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.09286Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.09286Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.1373Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.1907Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1907Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.202Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3491Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.3889Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.3889Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.4909Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.6941Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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