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Mammalian Phenotype (MP): abnormal immune system physiology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
0:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
- 1:   abnormal adaptive immunity [MP:0002420] <8>(36|48) (38|33|21)
- 1:   abnormal antigen presentation [MP:0001835] <6>(7|8) (7|4|2)
- 1:   abnormal innate immunity [MP:0002419] <5>(17|15) (18|9|5)
- 1:   abnormal humoral immune response [MP:0001800] <4>(10|14) (12|10|8)
- 1:   abnormal hypersensitivity reaction [MP:0002148] <4>(1|2) (1|1|0)
- 1:   abnormal immune organ physiology [MP:0003762] <4>(3|5) (3|1|0)
- 1:   abnormal immune serum protein physiology [MP:0002723] <4>(25|40) (31|24|12)
- 1:   abnormal inflammatory response [MP:0001845] <4>(27|38) (29|18|5)
- 1:   abnormal response to transplant [MP:0005671] <4>(2|2) (2|0|0)
- 1:   abnormal cell-mediated immunity [MP:0002421] <3>(35|48) (37|33|21)
- 1:   abnormal immune cell physiology [MP:0001819] <3>(35|48) (37|33|21)
- 1:   abnormal immune tolerance [MP:0005000] <3>(11|19) (13|8|1)
- 1:   abnormal lymphatic system physiology [MP:0010368] <2>(0|0) (0|0|0)
- 1:   abnormal response to antigen [MP:0020000] <2>(0|0) (0|0|0)
- 1:   abnormal response to infection [MP:0005025] <2>(18|31) (21|17|5)
- 1:   abnormal immunoglobulin transcytosis [MP:0010223](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
STAT0Direct
Anaphylotoxins (complement system)0Direct
Transcription factor STAT-4 N-domain0Direct
Resistin0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Toll/Interleukin receptor TIR domain0.000000000003059Direct
Immunoglobulin0.00001869Direct
DEATH domain0.00009729Direct
Caspase-like0.0001127Direct
C-type lectin-like0.000114Direct
TNF-like0.0002775Direct
Inhibitor of apoptosis (IAP) repeat0.001472Inherited
Alpha-macroglobulin receptor domain0.001472Inherited
p53-like transcription factors0.002541Inherited
SH3-domain0.003944Inherited
SH2 domain0.009116Inherited
Family A G protein-coupled receptor-like0.01014Inherited
4-helical cytokines0.01024Inherited
TNF receptor-like0.01891Inherited
Fibronectin type III0.02098Inherited
Kringle-like0.02836Inherited
Triple coiled coil domain of C-type lectins0.03012Inherited
Transducin (alpha subunit), insertion domain0.03509Inherited
PGBD-like0.06155Inherited
Hemopexin-like domain0.06155Inherited
SMAD/FHA domain0.06348Inherited
WWE domain0.06971Inherited
Trypsin-like serine proteases0.09192Inherited
E set domains0.09305Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1193Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1348Inherited
Riboflavin synthase domain-like0.1348Inherited
vWA-like0.1453Inherited
L domain-like0.1464Inherited
Interleukin 8-like chemokines0.1476Inherited
Integrin alpha N-terminal domain0.1709Inherited
Cysteine-rich domain0.1831Inherited
Bcl-2 inhibitors of programmed cell death0.1854Inherited
DBL homology domain (DH-domain)0.1871Inherited
Integrin domains0.2015Inherited
MHC antigen-recognition domain0.2015Inherited
Integrin beta tail domain0.2294Inherited
Complement control module/SCR domain0.3698Inherited
RNI-like0.4161Inherited
EGF/Laminin0.4219Inherited
Terpenoid cyclases/Protein prenyltransferases0.4632Inherited
dsRNA-binding domain-like0.4632Inherited
Nuclear receptor ligand-binding domain0.4926Inherited
Growth factor receptor domain0.6171Inherited
DNA/RNA polymerases0.6628Inherited
Flavoproteins0.7077Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.7327Inherited
Cystine-knot cytokines0.7397Inherited
L30e-like0.8689Inherited
CCCH zinc finger0.8689Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9355Inherited
Nicotinic receptor ligand binding domain-like0.9355Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
STAT DNA-binding domain0Direct
Resistin0Direct
STAT0Direct
Proteasome subunits0Direct
Interleukin 17F, IL-17F0Direct
Anaphylotoxins (complement system)0Direct
p53 tetramerization domain0Direct
Interleukin-1 (IL-1)0Direct
Transcription factor STAT-4 N-domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cysteine rich domain0Direct
Toll/Interleukin receptor TIR domain0.00000000001045Direct
TNF receptor-like0.00000002475Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00003689Direct
Interferon regulatory factor0.0001153Direct
Caspase recruitment domain, CARD0.0001395Direct
Caspase catalytic domain0.0002301Direct
TNF-like0.0002411Direct
DEATH domain, DD0.0004736Direct
C-type lectin domain0.0005234Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0008886Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0.001046Inherited
Complement components0.001046Inherited
Alpha-macroglobulin receptor domain0.001046Inherited
Interferons/interleukin-10 (IL-10)0.001729Inherited
Inhibitor of apoptosis (IAP) repeat0.003058Inherited
SH3-domain0.003732Inherited
Rhodopsin-like0.008291Inherited
SH2 domain0.00854Inherited
PLC-like (P variant)0.009272Inherited
C2 set domains0.01197Inherited
Triple coiled coil domain of C-type lectins0.02346Inherited
Cytochrome p450 reductase N-terminal domain-like0.02346Inherited
Fibronectin type III0.02475Inherited
V set domains (antibody variable domain-like)0.02689Inherited
WWE domain0.0277Inherited
Transducin (alpha subunit), insertion domain0.02956Inherited
Short-chain cytokines0.05109Inherited
Hemopexin-like domain0.05109Inherited
MMP N-terminal domain0.05109Inherited
Matrix metalloproteases, catalytic domain0.05109Inherited
Pleckstrin-homology domain (PH domain)0.0514Inherited
I set domains0.05247Inherited
EF-hand modules in multidomain proteins0.06415Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.06472Inherited
Netrin-like domain (NTR/C345C module)0.06472Inherited
NADPH-cytochrome p450 reductase-like0.06472Inherited
Fibronectin type II module0.08173Inherited
Integrin A (or I) domain0.08652Inherited
Papain-like0.09733Inherited
Eukaryotic proteases0.0974Inherited
28-residue LRR0.1036Inherited
Noncollagenous (NC1) domain of collagen IV0.1204Inherited
Kringle modules0.1324Inherited
Interleukin 8-like chemokines0.1336Inherited
C1 set domains (antibody constant domain-like)0.1576Inherited
Bcl-2 inhibitors of programmed cell death0.164Inherited
VWC domain0.164Inherited
Long-chain cytokines0.164Inherited
DBL homology domain (DH-domain)0.1847Inherited
MHC antigen-recognition domain0.1853Inherited
Integrin domains0.1853Inherited
Integrin beta EGF-like domains0.2061Inherited
Pyrin domain, PYD0.2061Inherited
Integrin beta tail domain0.2061Inherited
Integrin alpha N-terminal domain0.2211Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.264Inherited
Ngr ectodomain-like0.292Inherited
Complement control module/SCR domain0.3544Inherited
Double-stranded RNA-binding domain (dsRBD)0.3896Inherited
Notch domain0.4081Inherited
Cell cycle control phosphatase, catalytic domain0.4759Inherited
Nuclear receptor ligand-binding domain0.4849Inherited
Nuclear receptor0.4849Inherited
EGF-type module0.5971Inherited
FHA domain0.635Inherited
RING finger domain, C3HC40.8328Inherited
CCCH zinc finger0.8564Inherited
Transforming growth factor (TGF)-beta0.8615Inherited
ets domain0.8948Inherited
Nicotinic receptor ligand binding domain-like0.9348Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9348Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Resistin0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Anaphylotoxins (complement system)0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
Toll/Interleukin receptor TIR domain0.000000000001104Direct
Immunoglobulin0.000008326Direct
DEATH domain0.00004692Direct
Caspase-like0.00005494Direct
C-type lectin-like0.00005571Direct
TNF-like0.0001423Direct
Inhibitor of apoptosis (IAP) repeat0.0008239Direct
Alpha-macroglobulin receptor domain0.0008239Direct
p53-like transcription factors0.001462Inherited
SH3-domain0.002323Inherited
SH2 domain0.00565Inherited
Family A G protein-coupled receptor-like0.006337Inherited
4-helical cytokines0.006409Inherited
TNF receptor-like0.01233Inherited
Fibronectin type III0.01382Inherited
Kringle-like0.01917Inherited
Triple coiled coil domain of C-type lectins0.02048Inherited
Transducin (alpha subunit), insertion domain0.02415Inherited
Hemopexin-like domain0.04442Inherited
PGBD-like0.04442Inherited
SMAD/FHA domain0.04599Inherited
WWE domain0.05096Inherited
Protein kinase-like (PK-like)0.05293Inherited
Trypsin-like serine proteases0.06886Inherited
E set domains0.06972Inherited
PH domain-like0.08716Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.09203Inherited
Riboflavin synthase domain-like0.1054Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1054Inherited
vWA-like0.1146Inherited
L domain-like0.1155Inherited
Interleukin 8-like chemokines0.1165Inherited
Integrin alpha N-terminal domain0.137Inherited
Cysteine-rich domain0.1481Inherited
Bcl-2 inhibitors of programmed cell death0.1501Inherited
DBL homology domain (DH-domain)0.1516Inherited
MHC antigen-recognition domain0.1646Inherited
Integrin domains0.1646Inherited
Integrin beta tail domain0.1905Inherited
Complement control module/SCR domain0.3239Inherited
RNI-like0.369Inherited
EGF/Laminin0.375Inherited
Notch domain0.3888Inherited
Rhodanese/Cell cycle control phosphatase0.3969Inherited
Terpenoid cyclases/Protein prenyltransferases0.4154Inherited
dsRNA-binding domain-like0.4154Inherited
Nuclear receptor ligand-binding domain0.4449Inherited
Growth factor receptor domain0.5719Inherited
DNA/RNA polymerases0.6202Inherited
Flavoproteins0.6674Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.6938Inherited
Cystine-knot cytokines0.7012Inherited
"Winged helix" DNA-binding domain0.8309Inherited
RING/U-box0.8309Inherited
CCCH zinc finger0.8394Inherited
L30e-like0.8394Inherited
Cytokine0.8787Inherited
Nicotinic receptor ligand binding domain-like0.9123Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.9123Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    90188,53649
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    50370,57440
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    52047,52058
  • 52047 - RNI-like
  • 52058 - L domain-like
  • 0Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0Direct
    57440,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00002532Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.001133Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.00244Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.002469Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.00364Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00364Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.007246Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.009723Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.02048Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.02048Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.02282Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.04442Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04603Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.04713Inherited
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.05096Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.08108Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.09274Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.1165Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.1501Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1784Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1905Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.1905Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2018Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.2018Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.2412Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.2686Inherited
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.3058Inherited
    52821,52799
  • 52821 - Rhodanese/Cell cycle control phosphatase
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.3062Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3635Inherited
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.3888Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3938Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.6674Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.7117Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.9123Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57850,49599,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    57440,56436,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    56436,56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    50370,57440,56436
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    90188,90188,53649
  • 90188 - Somatomedin B domain
  • 90188 - Somatomedin B domain
  • 53649 - Alkaline phosphatase-like
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.007246Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.007246Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.007246Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.02282Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.09274Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.09274Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.137Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1905Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.1905Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.2018Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3488Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.3888Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.3888Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.4906Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.6938Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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