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Mammalian Phenotype (MP): altered susceptibility to infection

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + 2:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ 1:   abnormal response to infection [MP:0005025] <2>(18|31) (21|17|5)
0:   altered susceptibility to infection [MP:0001793] <8>(18|31) (21|17|5)
- 1:   decreased susceptibility to infection [MP:0002409] <6>(1|4) (1|1|0)
- 1:   increased susceptibility to infection [MP:0002406] <6>(11|19) (12|11|4)
- 1:   altered susceptibility to bacterial infection [MP:0020186] <2>(6|14) (7|7|2)
- 1:   altered susceptibility to fungal infection [MP:0020183] <2>(0|0) (0|0|0)
- 1:   altered susceptibility to infection induced morbidity/mortality [MP:0009785] <2>(2|2) (2|1|0)
- 1:   altered susceptibility to parasitic infection [MP:0020184] <2>(0|1) (0|1|0)
- 1:   altered susceptibility to prion infection [MP:0020187] <2>(0|0) (0|0|0)
- 1:   altered susceptibility to viral infection [MP:0020185] <2>(1|3) (1|1|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
DEATH domain0.000000000005563Direct
C-type lectin-like0.0000000001331Direct
4-helical cytokines0.0000000003175Direct
Toll/Interleukin receptor TIR domain0.0000000008533Direct
PGBD-like0.00002419Direct
MHC antigen-recognition domain0.0003263Direct
Triple coiled coil domain of C-type lectins0.0004328Direct
Hemopexin-like domain0.0006664Direct
TNF receptor-like0.002693Inherited
RNI-like0.003552Inherited
Alpha-macroglobulin receptor domain0.006203Inherited
dsRNA-binding domain-like0.0257Inherited
Caspase-like0.03526Inherited
p53-like transcription factors0.5326Inherited
Immunoglobulin0.577Inherited
STAT0.8235Inherited
Transcription factor STAT-4 N-domain0.8235Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
C-type lectin domain0.000000000001858Direct
Toll/Interleukin receptor TIR domain0.000000006245Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0.0000001983Direct
Caspase recruitment domain, CARD0.00000527Direct
Short-chain cytokines0.000009389Direct
MMP N-terminal domain0.00001751Direct
DEATH domain, DD0.00002085Direct
Interleukin 17F, IL-17F0.00002777Direct
Matrix metalloproteases, catalytic domain0.00002925Direct
C1 set domains (antibody constant domain-like)0.00004684Direct
Interferons/interleukin-10 (IL-10)0.0001088Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0002121Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0002271Direct
MHC antigen-recognition domain0.0002401Direct
Triple coiled coil domain of C-type lectins0.0002839Direct
Hemopexin-like domain0.0005001Direct
TNF receptor-like0.0005267Direct
Eukaryotic proteases0.0006604Direct
Netrin-like domain (NTR/C345C module)0.001033Inherited
Interleukin-1 (IL-1)0.001033Inherited
Long-chain cytokines0.001694Inherited
Complement components0.004589Inherited
Alpha-macroglobulin receptor domain0.004589Inherited
Fibronectin type II module0.01621Inherited
Caspase catalytic domain0.02191Inherited
Double-stranded RNA-binding domain (dsRBD)0.03589Inherited
Interferon regulatory factor0.7028Inherited
STAT DNA-binding domain0.8058Inherited
STAT0.8058Inherited
Transcription factor STAT-4 N-domain0.8058Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
DEATH domain0.00000000000201Direct
C-type lectin-like0.00000000004866Direct
4-helical cytokines0.0000000001163Direct
Toll/Interleukin receptor TIR domain0.0000000003158Direct
PGBD-like0.000011Direct
MHC antigen-recognition domain0.000169Direct
Triple coiled coil domain of C-type lectins0.000227Direct
Hemopexin-like domain0.0003565Direct
TNF-like0.0007318Direct
Trypsin-like serine proteases0.0008748Direct
TNF receptor-like0.001552Inherited
RNI-like0.002082Inherited
Alpha-macroglobulin receptor domain0.003764Inherited
Integrin alpha N-terminal domain0.01427Inherited
dsRNA-binding domain-like0.01722Inherited
Caspase-like0.02427Inherited
p53-like transcription factors0.4855Inherited
Immunoglobulin0.5306Inherited
STAT0.7903Inherited
Transcription factor STAT-4 N-domain0.7903Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0000002274Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00000536Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.000011Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.00004157Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0001691Direct
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.000227Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0005393Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0006568Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.001982Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.002642Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.006278Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.006278Inherited
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.009527Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.7903Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.7903Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.7903Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000169Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.001888Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.006278Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.7903Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.7903Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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