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Mammalian Phenotype (MP): autoimmune response

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + 3:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + 2:   abnormal immune tolerance [MP:0005000] <3>(11|19) (13|8|1)
+ 1:   abnormal self tolerance [MP:0005005] <1>(11|19) (13|8|1)
0:   autoimmune response [MP:0001844] <4>(11|19) (13|8|1)
- 1:   increased autoantibody level [MP:0003725] <4>(2|2) (2|1|0)
- 1:   altered susceptibility to autoimmune disorder [MP:0002425] <2>(2|9) (3|4|1)
- 1:   decreased autoantibody level [MP:0003726] <2>(0|0) (0|0|0)
- 1:   rheumatoid arthritis [MP:0003561](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Immunoglobulin0.00000000288Direct
4-helical cytokines0.0000000053Direct
SH2 domain0.000001679Direct
DEATH domain0.000001919Direct
TNF-like0.000002848Direct
TNF receptor-like0.000005977Direct
Fibronectin type III0.000116Direct
Toll/Interleukin receptor TIR domain0.0001878Direct
MHC antigen-recognition domain0.002676Inherited
L30e-like0.004009Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
V set domains (antibody variable domain-like)0.0000001787Direct
SH2 domain0.000002205Direct
TNF-like0.0000027Direct
Interleukin 17F, IL-17F0.000007267Direct
TNF receptor-like0.000008281Direct
Short-chain cytokines0.00002166Direct
DEATH domain, DD0.00009789Direct
PLC-like (P variant)0.00009832Direct
Toll/Interleukin receptor TIR domain0.0001112Direct
Fibronectin type III0.0001512Direct
Netrin-like domain (NTR/C345C module)0.0003912Direct
Interleukin-1 (IL-1)0.0003912Direct
Long-chain cytokines0.0004308Direct
C1 set domains (antibody constant domain-like)0.0004437Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0007318Direct
MHC antigen-recognition domain0.002197Inherited
C2 set domains0.004773Inherited
Papain-like0.01618Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Immunoglobulin0.000000001081Direct
4-helical cytokines0.000000002Direct
SH2 domain0.0000006899Direct
DEATH domain0.0000007908Direct
TNF-like0.000001198Direct
TNF receptor-like0.000002574Direct
Fibronectin type III0.00005683Direct
Toll/Interleukin receptor TIR domain0.00009446Direct
Protein kinase-like (PK-like)0.000611Direct
MHC antigen-recognition domain0.001542Inherited
L30e-like0.002365Inherited
p53-like transcription factors0.00606Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0000002657Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.00005765Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0001147Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0001681Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0005315Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0006238Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002365Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000004673Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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