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Mammalian Phenotype (MP): increased inflammatory response

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + 2:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ 1:   abnormal inflammatory response [MP:0001845] <4>(27|38) (29|18|5)
0:   increased inflammatory response [MP:0001846] <35>(23|35) (25|17|4)
- 1:   eye inflammation [MP:0001851] <12>(0|0) (0|0|0)
- 1:   reproductive system inflammation [MP:0002254] <8>(0|0) (0|0|0)
- 1:   increased acute inflammation [MP:0005088] <5>(0|0) (0|0|0)
- 1:   pancreas inflammation [MP:0001869] <5>(0|2) (0|0|0)
- 1:   joint inflammation [MP:0002933] <4>(6|6) (6|5|0)
- 1:   renal/urinary system inflammation [MP:0011762] <4>(3|5) (4|3|0)
- 1:   respiratory system inflammation [MP:0002405] <4>(2|5) (3|1|0)
- 1:   heart inflammation [MP:0001853] <3>(0|0) (0|0|0)
- 1:   salivary gland inflammation [MP:0001870] <3>(0|1) (0|0|0)
- 1:   skin inflammation [MP:0004947] <3>(0|2) (1|0|0)
- 1:   intestinal inflammation [MP:0001858] <2>(8|9) (8|3|2)
- 1:   CNS inflammation [MP:0006082] <1>(0|1) (1|0|0)
- 1:   ear inflammation [MP:0001849] <1>(0|0) (0|0|0)
- 1:   vascular inflammation [MP:0001863] <1>(0|0) (0|0|0)
- 1:   adipose tissue inflammation [MP:0020386](0|0) (0|0|0)
- 1:   bile duct inflammation [MP:0003254](0|0) (0|0|0)
- 1:   diaphragmitis [MP:0013467](0|0) (0|0|0)
- 1:   esophageal inflammation [MP:0003278](0|0) (0|0|0)
- 1:   folliculitis [MP:0000376](0|0) (0|0|0)
- 1:   gallbladder inflammation [MP:0003251](0|0) (0|0|0)
- 1:   lacrimal gland inflammation [MP:0008880](0|0) (0|0|0)
- 1:   lip inflammation [MP:0003777](0|0) (0|0|0)
- 1:   liver inflammation [MP:0001860](0|0) (0|0|0)
- 1:   lymph node inflammation [MP:0003865](0|0) (0|0|0)
- 1:   mastitis [MP:0013148](0|0) (0|0|0)
- 1:   myositis [MP:0004510](0|0) (0|0|0)
- 1:   osteomyelitis [MP:0005190](0|0) (0|0|0)
- 1:   palate inflammation [MP:0003767](0|0) (0|0|0)
- 1:   panniculitis [MP:0011164](0|0) (0|0|0)
- 1:   peritoneal inflammation [MP:0003303](0|0) (0|0|0)
- 1:   perivasculitis [MP:0012565](0|0) (0|0|0)
- 1:   prostate gland inflammation [MP:0003608](0|0) (0|0|0)
- 1:   stomach inflammation [MP:0001873](0|0) (0|0|0)
- 1:   stomatitis [MP:0003746](0|0) (0|0|0)
- 1:   thyroid inflammation [MP:0003504](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Anaphylotoxins (complement system)0Direct
Resistin0Direct
p53 tetramerization domain0Direct
Integrin beta tail domain0.00001852Direct
Alpha-macroglobulin receptor domain0.00001852Direct
Terpenoid cyclases/Protein prenyltransferases0.0007827Direct
RNI-like0.006669Inherited
Kringle-like0.007777Inherited
Growth factor receptor domain0.02808Inherited
L30e-like0.05406Inherited
Nuclear receptor ligand-binding domain0.1831Inherited
Toll/Interleukin receptor TIR domain0.2741Inherited
p53-like transcription factors0.2994Inherited
4-helical cytokines0.3779Inherited
TNF-like0.5818Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.6186Inherited
Riboflavin synthase domain-like0.6186Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6266Inherited
Nicotinic receptor ligand binding domain-like0.6266Inherited
DEATH domain0.7692Inherited
PGBD-like0.9094Inherited
Hemopexin-like domain0.9094Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Resistin0Direct
Anaphylotoxins (complement system)0Direct
p53 tetramerization domain0Direct
Interleukin-1 (IL-1)0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00000004624Direct
Integrin beta tail domain0.00001362Direct
Complement components0.00001362Direct
Alpha-macroglobulin receptor domain0.00001362Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00001796Direct
Integrin beta EGF-like domains0.00007671Direct
Interleukin 17F, IL-17F0.0004647Direct
VWC domain0.0006688Direct
PLC-like (P variant)0.00244Inherited
Interferons/interleukin-10 (IL-10)0.002478Inherited
28-residue LRR0.0135Inherited
Noncollagenous (NC1) domain of collagen IV0.01736Inherited
Papain-like0.06295Inherited
Nuclear receptor ligand-binding domain0.1524Inherited
Nuclear receptor0.1524Inherited
V set domains (antibody variable domain-like)0.1709Inherited
RING finger domain, C3HC40.198Inherited
Ngr ectodomain-like0.2135Inherited
Toll/Interleukin receptor TIR domain0.2664Inherited
TNF receptor-like0.4165Inherited
Pyrin domain, PYD0.5193Inherited
TNF-like0.543Inherited
Caspase recruitment domain, CARD0.5799Inherited
Nicotinic receptor ligand binding domain-like0.6365Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6365Inherited
Short-chain cytokines0.7159Inherited
Hemopexin-like domain0.89Inherited
MMP N-terminal domain0.89Inherited
Matrix metalloproteases, catalytic domain0.89Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Resistin0Direct
p53 tetramerization domain0Direct
Anaphylotoxins (complement system)0Direct
Integrin beta tail domain0.000008246Direct
Alpha-macroglobulin receptor domain0.000008246Direct
Terpenoid cyclases/Protein prenyltransferases0.0004215Direct
RNI-like0.004068Inherited
Kringle-like0.004775Inherited
Growth factor receptor domain0.01897Inherited
L30e-like0.03844Inherited
Nuclear receptor ligand-binding domain0.148Inherited
Cytokine0.2057Inherited
Toll/Interleukin receptor TIR domain0.2324Inherited
p53-like transcription factors0.2561Inherited
4-helical cytokines0.3317Inherited
TNF receptor-like0.3646Inherited
TNF-like0.5355Inherited
Riboflavin synthase domain-like0.5734Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.5734Inherited
Nicotinic receptor ligand binding domain-like0.5819Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.5819Inherited
DEATH domain0.7319Inherited
Hemopexin-like domain0.8833Inherited
PGBD-like0.8833Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    52047,52058
  • 52047 - RNI-like
  • 52058 - L domain-like
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00000002125Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.000008246Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.00004894Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00004894Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.0002717Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0004116Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0006046Direct
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.01386Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.08462Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.5116Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.5734Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.5819Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.8833Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.000008246Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0003383Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0003383Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0003383Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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