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Mammalian Phenotype (MP): abnormal reproductive system physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   reproductive system phenotype [MP:0005389] <2>(38|58) (47|18|6)
0:   abnormal reproductive system physiology [MP:0001919] <10>(21|39) (27|11|2)
- 1:   abnormal female reproductive system physiology [MP:0003699] <13>(10|24) (17|6|2)
- 1:   abnormal male reproductive system physiology [MP:0003698] <12>(4|8) (4|4|0)
- 1:   reproductive system inflammation [MP:0002254] <8>(0|0) (0|0|0)
- 1:   abnormal fertility/fecundity [MP:0002161] <7>(8|20) (10|3|0)
- 1:   abnormal germ cell physiology [MP:0020363] <5>(0|0) (0|0|0)
- 1:   abnormal fertilization [MP:0005410] <4>(2|2) (2|1|0)
- 1:   abnormal sex gland physiology [MP:0005647] <4>(1|2) (2|1|0)
- 1:   genital hemorrhage [MP:0004245] <2>(1|2) (2|0|0)
- 1:   abnormal copulation [MP:0009697] <1>(0|0) (0|0|0)
- 1:   genital discharge [MP:0013136](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
SMAD MH1 domain0.0000336Direct
PAZ domain0.006532Inherited
HMA, heavy metal-associated domain0.009403Inherited
The spindle assembly checkpoint protein mad20.009403Inherited
Flavoproteins0.01919Inherited
Nuclear receptor ligand-binding domain0.02422Inherited
Nucleic acid-binding proteins0.08228Inherited
Alpha-macroglobulin receptor domain0.08473Inherited
PYP-like sensor domain (PAS domain)0.08527Inherited
SMAD/FHA domain0.1077Inherited
Metalloproteases ("zincins"), catalytic domain0.1088Inherited
Blood coagulation inhibitor (disintegrin)0.1204Inherited
4-helical cytokines0.1283Inherited
Alkaline phosphatase-like0.1718Inherited
Terpenoid cyclases/Protein prenyltransferases0.2048Inherited
E2F-DP heterodimerization region0.5367Inherited
Tudor/PWWP/MBT0.5419Inherited
EGF/Laminin0.8861Inherited
Fibronectin type III0.919Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
SMAD MH1 domain0.00002061Direct
SMAD domain0.00002061Direct
Linker histone H1/H50.001424Inherited
Gonadodropin/Follitropin0.001668Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001668Inherited
NADPH-cytochrome p450 reductase-like0.001668Inherited
PAZ domain0.004697Inherited
Neurotrophin0.006651Inherited
HMA, heavy metal-associated domain0.006651Inherited
The spindle assembly checkpoint protein mad20.006651Inherited
gamma-adaptin C-terminal appendage domain-like0.006651Inherited
DNA gyrase/MutL, second domain0.006651Inherited
DNA gyrase/MutL, N-terminal domain0.006651Inherited
STAT DNA-binding domain0.01442Inherited
STAT0.01442Inherited
Transcription factor STAT-4 N-domain0.01442Inherited
Single strand DNA-binding domain, SSB0.01442Inherited
Nuclear receptor ligand-binding domain0.01861Inherited
Nuclear receptor0.02499Inherited
Long-chain cytokines0.02634Inherited
Astacin0.04133Inherited
Complement components0.06921Inherited
Alpha-macroglobulin receptor domain0.06921Inherited
Blood coagulation inhibitor (disintegrin)0.1042Inherited
Tudor domain0.1647Inherited
Reprolysin-like0.2878Inherited
Short-chain cytokines0.3318Inherited
E2F dimerization segment0.5042Inherited
Ngr ectodomain-like0.5505Inherited
Transforming growth factor (TGF)-beta0.7369Inherited
EGF-type module0.7684Inherited
I set domains0.8643Inherited
Fibronectin type III0.9097Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
SMAD MH1 domain0.00001548Direct
PAZ domain0.00398Inherited
HMA, heavy metal-associated domain0.00585Inherited
The spindle assembly checkpoint protein mad20.00585Inherited
Flavoproteins0.01254Inherited
STAT0.01254Inherited
Transcription factor STAT-4 N-domain0.01254Inherited
Nuclear receptor ligand-binding domain0.01614Inherited
Nucleic acid-binding proteins0.06089Inherited
Alpha-macroglobulin receptor domain0.06289Inherited
PYP-like sensor domain (PAS domain)0.06332Inherited
SMAD/FHA domain0.08204Inherited
Metalloproteases ("zincins"), catalytic domain0.08292Inherited
Blood coagulation inhibitor (disintegrin)0.09287Inherited
4-helical cytokines0.09965Inherited
Alkaline phosphatase-like0.1378Inherited
Terpenoid cyclases/Protein prenyltransferases0.1675Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2707Inherited
L domain-like0.4742Inherited
E2F-DP heterodimerization region0.4897Inherited
Tudor/PWWP/MBT0.4951Inherited
EGF/Laminin0.8581Inherited
Family A G protein-coupled receptor-like0.8675Inherited
Fibronectin type III0.8938Inherited
Immunoglobulin1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01254Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01254Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01254Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.01817Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.02053Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0859Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.09287Inherited
    51206,51206
  • 51206 - cAMP-binding domain-like
  • 51206 - cAMP-binding domain-like
  • 0.09366Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.4897Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8684Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01254Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01254Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)