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Mammalian Phenotype (MP): neoplasm

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
- 1:   altered tumor pathology [MP:0010639] <4>(9|11) (10|8|5)
- 1:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Protein kinase-like (PK-like)0.000000006774Direct
SMAD MH1 domain0.00003976Direct
4-helical cytokines0.000102Direct
DNA/RNA polymerases0.0001514Direct
Bcl-2 inhibitors of programmed cell death0.001518Inherited
SMAD/FHA domain0.001868Inherited
Restriction endonuclease-like0.002Inherited
SPOC domain-like0.002Inherited
DNA-glycosylase0.002Inherited
Cyclin-like0.002703Inherited
Nucleic acid-binding proteins0.003743Inherited
SAND domain-like0.006443Inherited
DNA repair protein MutS, domain III0.006443Inherited
Notch domain0.006443Inherited
RING/U-box0.009593Inherited
PGBD-like0.01398Inherited
Integrin beta tail domain0.02363Inherited
STAT0.02363Inherited
Transcription factor STAT-4 N-domain0.02363Inherited
Putative DNA-binding domain0.02363Inherited
Hemopexin-like domain0.02895Inherited
p53-like transcription factors0.03167Inherited
BRCT domain0.04278Inherited
Kringle-like0.09072Inherited
CCCH zinc finger0.1088Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1934Inherited
SET domain0.1999Inherited
ARM repeat0.2128Inherited
Metalloproteases ("zincins"), catalytic domain0.2244Inherited
Ubiquitin-like0.5116Inherited
Intermediate filament protein, coiled coil region0.5648Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Protein kinases, catalytic subunit0.0000004534Direct
SMAD MH1 domain0.00002984Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.00002984Direct
SMAD domain0.00002984Direct
DNA polymerase I0.0009854Direct
Bcl-2 inhibitors of programmed cell death0.001208Inherited
XPF/Rad1/Mus81 nuclease0.001482Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001834Inherited
Pointed domain0.002529Inherited
L domain0.002529Inherited
Matrix metalloproteases, catalytic domain0.004361Inherited
Notch domain0.005016Inherited
DNA repair protein MutS, domain III0.005016Inherited
Interferons/interleukin-10 (IL-10)0.009034Inherited
Short-chain cytokines0.009838Inherited
MMP N-terminal domain0.01246Inherited
p120GAP domain-like0.01423Inherited
Integrin beta tail domain0.01966Inherited
STAT DNA-binding domain0.01966Inherited
Single strand DNA-binding domain, SSB0.01966Inherited
Transcription factor STAT-4 N-domain0.01966Inherited
STAT0.01966Inherited
Pyrin domain, PYD0.01966Inherited
Forkhead DNA-binding domain0.0227Inherited
Hemopexin-like domain0.02639Inherited
DnaQ-like 3'-5' exonuclease0.02915Inherited
Integrin beta EGF-like domains0.03072Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.046Inherited
Histone lysine methyltransferases0.0728Inherited
CCCH zinc finger0.09941Inherited
FHA domain0.1678Inherited
Phosphotyrosine-binding domain (PTB)0.5529Inherited
Intermediate filament protein, coiled coil region0.574Inherited
ABC transporter ATPase domain-like0.5987Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Protein kinase-like (PK-like)0.000000002564Direct
SMAD MH1 domain0.00001847Direct
4-helical cytokines0.00004941Direct
DNA/RNA polymerases0.00007561Direct
Bcl-2 inhibitors of programmed cell death0.0008508Direct
SMAD/FHA domain0.001059Inherited
SPOC domain-like0.001136Inherited
Restriction endonuclease-like0.001136Inherited
DNA-glycosylase0.001136Inherited
Cyclin-like0.001557Inherited
Nucleic acid-binding proteins0.002195Inherited
SAND domain-like0.003923Inherited
Notch domain0.003923Inherited
DNA repair protein MutS, domain III0.003923Inherited
RING/U-box0.005976Inherited
PGBD-like0.008951Inherited
Chromo domain-like0.009515Inherited
Snake toxin-like0.01415Inherited
Integrin beta tail domain0.01571Inherited
STAT0.01571Inherited
Putative DNA-binding domain0.01571Inherited
Transcription factor STAT-4 N-domain0.01571Inherited
Hemopexin-like domain0.0196Inherited
p53-like transcription factors0.02164Inherited
BRCT domain0.02985Inherited
Cysteine-rich domain0.04284Inherited
ENTH/VHS domain0.05114Inherited
Kringle-like0.06778Inherited
Ribonuclease H-like0.06823Inherited
Leucine zipper domain0.08149Inherited
CCCH zinc finger0.083Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1574Inherited
SET domain0.1633Inherited
ARM repeat0.175Inherited
Metalloproteases ("zincins"), catalytic domain0.186Inherited
Ubiquitin-like0.4642Inherited
Intermediate filament protein, coiled coil region0.5183Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.00002261Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.001136Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.001698Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.001879Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001879Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.003858Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.003858Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.003923Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.008951Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01571Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.01571Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01571Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01571Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01571Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.03097Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.0633Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1777Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.001136Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001879Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.003923Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01571Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01571Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01571Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1023Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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