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Mammalian Phenotype (MP): neoplasm

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <29>
0:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
- 1:   altered tumor pathology [MP:0010639] <4>(9|11) (10|8|5)
- 1:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Protein kinase-like (PK-like)0.000000006818Direct
SMAD MH1 domain0.00003983Direct
4-helical cytokines0.0001023Direct
DNA/RNA polymerases0.0001516Direct
Bcl-2 inhibitors of programmed cell death0.001519Inherited
SMAD/FHA domain0.00187Inherited
SPOC domain-like0.002Inherited
DNA-glycosylase0.002Inherited
Restriction endonuclease-like0.002Inherited
Cyclin-like0.002705Inherited
Nucleic acid-binding proteins0.003745Inherited
DNA repair protein MutS, domain III0.006444Inherited
SAND domain-like0.006444Inherited
Notch domain0.006444Inherited
RING/U-box0.009608Inherited
PGBD-like0.01398Inherited
Putative DNA-binding domain0.02364Inherited
Integrin beta tail domain0.02364Inherited
STAT0.02364Inherited
Transcription factor STAT-4 N-domain0.02364Inherited
Hemopexin-like domain0.02895Inherited
p53-like transcription factors0.03169Inherited
BRCT domain0.04281Inherited
Kringle-like0.0907Inherited
CCCH zinc finger0.1088Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1934Inherited
SET domain0.1999Inherited
ARM repeat0.2129Inherited
Metalloproteases ("zincins"), catalytic domain0.2244Inherited
Ubiquitin-like0.5118Inherited
Intermediate filament protein, coiled coil region0.565Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
p53 tetramerization domain0Direct
Protein kinases, catalytic subunit0.0000004568Direct
SMAD MH1 domain0.00002988Direct
SMAD domain0.00002988Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.00002988Direct
DNA polymerase I0.0009856Direct
Bcl-2 inhibitors of programmed cell death0.001208Inherited
XPF/Rad1/Mus81 nuclease0.001482Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001834Inherited
Pointed domain0.002529Inherited
L domain0.002529Inherited
Matrix metalloproteases, catalytic domain0.00436Inherited
Notch domain0.005016Inherited
DNA repair protein MutS, domain III0.005016Inherited
Interferons/interleukin-10 (IL-10)0.009026Inherited
Short-chain cytokines0.009837Inherited
MMP N-terminal domain0.01246Inherited
p120GAP domain-like0.01423Inherited
STAT DNA-binding domain0.01965Inherited
STAT0.01965Inherited
Pyrin domain, PYD0.01965Inherited
Integrin beta tail domain0.01965Inherited
Transcription factor STAT-4 N-domain0.01965Inherited
Single strand DNA-binding domain, SSB0.01965Inherited
Forkhead DNA-binding domain0.02271Inherited
Hemopexin-like domain0.02641Inherited
DnaQ-like 3'-5' exonuclease0.02917Inherited
Integrin beta EGF-like domains0.03072Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.04601Inherited
Histone lysine methyltransferases0.0728Inherited
CCCH zinc finger0.09942Inherited
FHA domain0.1678Inherited
Phosphotyrosine-binding domain (PTB)0.5531Inherited
Intermediate filament protein, coiled coil region0.5741Inherited
ABC transporter ATPase domain-like0.5989Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Protein kinase-like (PK-like)0.000000002581Direct
SMAD MH1 domain0.00001848Direct
4-helical cytokines0.0000495Direct
DNA/RNA polymerases0.00007566Direct
Bcl-2 inhibitors of programmed cell death0.0008512Direct
SMAD/FHA domain0.00106Inherited
DNA-glycosylase0.001136Inherited
Restriction endonuclease-like0.001136Inherited
SPOC domain-like0.001136Inherited
Cyclin-like0.001558Inherited
Nucleic acid-binding proteins0.002196Inherited
DNA repair protein MutS, domain III0.003924Inherited
SAND domain-like0.003924Inherited
Notch domain0.003924Inherited
RING/U-box0.005983Inherited
PGBD-like0.008953Inherited
Chromo domain-like0.009516Inherited
Snake toxin-like0.01416Inherited
Integrin beta tail domain0.01572Inherited
Putative DNA-binding domain0.01572Inherited
STAT0.01572Inherited
Transcription factor STAT-4 N-domain0.01572Inherited
Hemopexin-like domain0.0196Inherited
p53-like transcription factors0.02165Inherited
BRCT domain0.02987Inherited
Cysteine-rich domain0.04286Inherited
ENTH/VHS domain0.05114Inherited
Kringle-like0.06777Inherited
Ribonuclease H-like0.06826Inherited
Leucine zipper domain0.08151Inherited
CCCH zinc finger0.08302Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1573Inherited
SET domain0.1633Inherited
ARM repeat0.1751Inherited
Metalloproteases ("zincins"), catalytic domain0.186Inherited
Ubiquitin-like0.4644Inherited
Intermediate filament protein, coiled coil region0.5184Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.00002265Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.001136Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.001699Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.001879Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001879Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.003859Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.003859Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.003924Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.008953Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01572Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01572Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.01572Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01572Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01572Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.03098Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.06332Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1778Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.001136Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001879Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.003924Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01572Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01572Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01572Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1023Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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