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Mammalian Phenotype (MP): increased malignant tumor incidence

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   mammalian phenotype [MP:0000001] <29>
+ + + + + 5:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
+ + + + 4:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)
+ + + 3:   abnormal tumor incidence [MP:0002019] <6>(25|29) (30|11|3)
+ + 2:   abnormal classified tumor incidence [MP:0020188] <3>(20|19) (26|7|1)
+ + 2:   increased tumor incidence [MP:0002020] <3>(25|27) (30|10|3)
+ 1:   increased classified tumor incidence [MP:0010273] <19>(20|19) (26|7|1)
0:   increased malignant tumor incidence [MP:0002018] <5>(7|11) (10|6|0)
- 1:   increased carcinoma incidence [MP:0002038] <16>(7|9) (9|6|0)
- 1:   increased sarcoma incidence [MP:0002032] <9>(1|5) (2|2|0)
- 1:   increased blastoma incidence [MP:0008021] <6>(1|1) (1|0|0)
- 1:   increased melanoma incidence [MP:0010275] <2>(0|0) (0|0|0)
- 1:   increased malignant triton tumor incidence [MP:0002033](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
DNA repair protein MutS, domain III0.0004487Direct
p53-like transcription factors0.007093Inherited
SMAD MH1 domain0.2178Inherited
DNA/RNA polymerases0.2178Inherited
SMAD/FHA domain0.4077Inherited
Cyclin-like0.4395Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
Retinoblastoma tumor suppressor domains0Direct
DNA repair protein MutS, domain III0.0002977Direct
p120GAP domain-like0.0005327Direct
DnaQ-like 3'-5' exonuclease0.01005Inherited
SMAD MH1 domain0.1759Inherited
SMAD domain0.1759Inherited
Phosphotyrosine-binding domain (PTB)0.1997Inherited
FHA domain0.3155Inherited
DNA polymerase I0.3155Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
DNA repair protein MutS, domain III0.0002356Direct
Snake toxin-like0.002242Inherited
p53-like transcription factors0.004345Inherited
BRCT domain0.1798Inherited
SMAD MH1 domain0.1798Inherited
DNA/RNA polymerases0.1798Inherited
Ribonuclease H-like0.2392Inherited
SMAD/FHA domain0.3609Inherited
Cyclin-like0.392Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0002356Direct
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.001445Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.001945Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.001945Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.01446Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)