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Mammalian Phenotype (MP): increased carcinoma incidence

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + 7:   mammalian phenotype [MP:0000001] <29>
+ + + + + + 6:   neoplasm [MP:0002006] <2>(32|37) (38|18|7)
+ + + + + 5:   altered tumor susceptibility [MP:0002166] <3>(25|29) (30|11|3)
+ + + + 4:   abnormal tumor incidence [MP:0002019] <6>(25|29) (30|11|3)
+ + + 3:   abnormal classified tumor incidence [MP:0020188] <3>(20|19) (26|7|1)
+ + + 3:   increased tumor incidence [MP:0002020] <3>(25|27) (30|10|3)
+ + 2:   increased classified tumor incidence [MP:0010273] <19>(20|19) (26|7|1)
+ 1:   increased malignant tumor incidence [MP:0002018] <5>(7|11) (10|6|0)
0:   increased carcinoma incidence [MP:0002038] <16>(7|9) (9|6|0)
- 1:   increased adenocarcinoma incidence [MP:0009308] <9>(3|4) (4|4|0)
- 1:   increased lung carcinoma incidence [MP:0008714] <2>(1|2) (1|2|0)
- 1:   increased squamous cell carcinoma incidence [MP:0004207] <2>(1|2) (1|1|0)
- 1:   increased thyroid carcinoma incidence [MP:0010346] <1>(0|0) (0|0|0)
- 1:   increased urinary bladder carcinoma incidence [MP:0009550] <1>(1|1) (1|0|0)
- 1:   increased basal cell carcinoma incidence [MP:0004208](0|0) (0|0|0)
- 1:   increased cholangiocarcinoma incidence [MP:0010315](0|0) (0|0|0)
- 1:   increased endometrial carcinoma incidence [MP:0004868](0|0) (0|0|0)
- 1:   increased hepatocellular carcinoma incidence [MP:0003331](0|2) (0|1|0)
- 1:   increased mammary gland ductal carcinoma incidence [MP:0009508](0|0) (0|0|0)
- 1:   increased ovarian carcinoma incidence [MP:0003579](1|2) (1|0|0)
- 1:   increased pancreatic islet cell carcinoma incidence [MP:0010348](0|0) (0|0|0)
- 1:   increased renal carcinoma incidence [MP:0010384](0|0) (0|0|0)
- 1:   increased spindle cell carcinoma incidence [MP:0010367](0|0) (0|0|0)
- 1:   increased teratocarcinoma incidence [MP:0010349](0|0) (0|0|0)
- 1:   increased uterus carcinoma incidence [MP:0009223](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.000002804Direct
DNA/RNA polymerases0.00005674Direct
SMAD/FHA domain0.0002095Direct
DNA repair protein MutS, domain III0.0002186Direct
Cyclin-like0.003535Inherited
p53-like transcription factors0.3811Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
p53 tetramerization domain0Direct
Retinoblastoma tumor suppressor domains0Direct
SMAD MH1 domain0.000001847Direct
SMAD domain0.000001847Direct
DNA repair protein MutS, domain III0.0001431Direct
p120GAP domain-like0.0002218Direct
DNA polymerase I0.0003549Direct
FHA domain0.02927Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
SMAD MH1 domain0.00000118Direct
DNA/RNA polymerases0.00002672Direct
SMAD/FHA domain0.0001061Direct
DNA repair protein MutS, domain III0.000111Direct
Snake toxin-like0.0007317Direct
Cyclin-like0.00207Inherited
p53-like transcription factors0.3349Inherited
BRCT domain0.458Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.000111Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0009628Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0009628Direct
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.006822Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.5365Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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