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Mammalian Phenotype (MP): prenatal lethality

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   mortality/aging [MP:0010768] <4>(83|115) (89|67|50)
+ 1:   preweaning lethality [MP:0010770] <4>(48|79) (55|45|38)
+ 1:   abnormal survival [MP:0010769] <10>(60|91) (67|55|39)
0:   prenatal lethality [MP:0002080] <5>(27|49) (30|23|16)
- 1:   embryonic lethality [MP:0008762] <4>(16|30) (16|11|7)
- 1:   lethality throughout fetal growth and development [MP:0006208] <2>(5|8) (6|6|7)
- 1:   prenatal lethality prior to heart atrial septation [MP:0013294](0|0) (0|0|0)
- 1:   prenatal lethality, complete penetrance [MP:0011091](0|2) (0|0|0)
- 1:   prenatal lethality, incomplete penetrance [MP:0011101](2|5) (4|1|1)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
p53 tetramerization domain0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
Ribonuclease PH domain 2-like0Direct
Zinc beta-ribbon0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
GroEL-intermediate domain like0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
"Winged helix" DNA-binding domain0.0007805Direct
ARM repeat0.001415Inherited
Nucleic acid-binding proteins0.003411Inherited
GroEL apical domain-like0.01053Inherited
HCP-like0.01347Inherited
Protein kinase-like (PK-like)0.01609Inherited
BRCT domain0.01699Inherited
SCOP hierarchy in SUPERFAMILY0.02143Inherited
E2F-DP heterodimerization region0.05362Inherited
Flavoproteins0.06528Inherited
p53-like transcription factors0.08256Inherited
DNA clamp0.1279Inherited
SMAD MH1 domain0.1428Inherited
ADC-like0.1946Inherited
Cullin homology domain0.2014Inherited
Subtilisin-like0.2014Inherited
TB module/8-cys domain0.2796Inherited
dsRNA-binding domain-like0.3324Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
SMAD4-binding domain of oncoprotein Ski0Direct
Pointed domain0Direct
DNA ligase0Direct
Chromo barrel domain0Direct
DNA ligase/mRNA capping enzyme postcatalytic domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
ATP-dependent DNA ligase catalytic domain0Direct
p53 tetramerization domain0Direct
SIAH, seven in absentia homolog0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
Ribonuclease PH domain 1-like0Direct
Fumble-like0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Ribonuclease PH domain 2-like0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.0002668Direct
RecA protein-like (ATPase-domain)0.0005909Direct
Inhibitor of apoptosis (IAP) repeat0.002491Inherited
Extracellular domain of cell surface receptors0.003999Inherited
ets domain0.004538Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.007335Inherited
NADPH-cytochrome p450 reductase-like0.007335Inherited
N-acetyl transferase, NAT0.008533Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.008533Inherited
Cell cycle transcription factor e2f-dp0.01409Inherited
Histone lysine methyltransferases0.01746Inherited
C5 cytosine-specific DNA methylase, DCM0.02073Inherited
DNA polymerase I0.02397Inherited
Proprotein convertase P-domain0.02397Inherited
Prohormone convertase 1 pro-domain0.02397Inherited
Erythroid transcription factor GATA-10.03787Inherited
Protein kinases, catalytic subunit0.03799Inherited
Adenain-like0.05774Inherited
Subtilases0.06159Inherited
E2F dimerization segment0.06159Inherited
Tandem AAA-ATPase domain0.08218Inherited
SCF ubiquitin ligase complex WHB domain0.09974Inherited
SMAD MH1 domain0.1118Inherited
SMAD domain0.1118Inherited
Extended AAA-ATPase domain0.1321Inherited
Linker histone H1/H50.1326Inherited
Cullin homology domain0.164Inherited
T-box0.1678Inherited
TB module/8-cys domain0.2369Inherited
Armadillo repeat0.2515Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH0.7499Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
GroEL-intermediate domain like0Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP700Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
Zinc beta-ribbon0Direct
Ribonuclease PH domain 2-like0Direct
p53 tetramerization domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
"Winged helix" DNA-binding domain0.0004202Direct
ARM repeat0.0007894Direct
Nucleic acid-binding proteins0.001992Inherited
GroEL apical domain-like0.006603Inherited
HCP-like0.00859Inherited
Inhibitor of apoptosis (IAP) repeat0.00859Inherited
Protein kinase-like (PK-like)0.01039Inherited
BRCT domain0.01103Inherited
E2F-DP heterodimerization region0.03809Inherited
Flavoproteins0.0474Inherited
Acyl-CoA N-acyltransferases (Nat)0.05345Inherited
p53-like transcription factors0.06111Inherited
DNA clamp0.0993Inherited
SMAD MH1 domain0.1123Inherited
ADC-like0.1584Inherited
Cullin homology domain0.1645Inherited
Subtilisin-like0.1645Inherited
Riboflavin synthase domain-like0.2273Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2273Inherited
TB module/8-cys domain0.2376Inherited
dsRNA-binding domain-like0.2878Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,82895
  • 57184 - Growth factor receptor domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    46955,63763
  • 46955 - Putative DNA-binding domain
  • 63763 - SAND domain-like
  • 0Direct
    117018,56091
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    54160,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02077Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0214Inherited
    52743,49785
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0.022Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.03809Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.05385Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.08438Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.0993Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0993Inherited
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0993Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.1584Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.1645Inherited
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.3388Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.3912Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.3912Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    75399,75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    117018,56091,50249
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    54160,54160,52540
  • 54160 - Chromo domain-like
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02077Inherited
    54160,52540,52540
  • 54160 - Chromo domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02077Inherited
    54897,52743,49785
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 49785 - Galactose-binding domain-like
  • 0.022Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.05385Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.0993Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.1584Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1584Inherited
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.3388Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.3912Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)