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Mammalian Phenotype (MP): abnormal embryonic tissue morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   embryo phenotype [MP:0005380] <7>(40|54) (46|28|19)
+ 1:   abnormal embryo morphology [MP:0014134] <4>(23|31) (26|14|12)
0:   abnormal embryonic tissue morphology [MP:0002085] <35>(17|21) (19|10|9)
- 1:   abnormal neural tube morphology [MP:0002151] <16>(7|8) (7|4|3)
- 1:   abnormal pharyngeal arch morphology [MP:0002884] <11>(0|0) (1|1|0)
- 1:   abnormal somite development [MP:0001688] <11>(3|5) (3|3|1)
- 1:   abnormal head mesenchyme morphology [MP:0011260] <10>(1|1) (1|0|0)
- 1:   abnormal limb bud morphology [MP:0005650] <8>(0|2) (1|0|0)
- 1:   abnormal primitive streak morphology [MP:0002231] <7>(3|2) (3|0|0)
- 1:   abnormal notochord morphology [MP:0002825] <6>(0|0) (1|0|0)
- 1:   abnormal tail bud morphology [MP:0002861] <6>(1|1) (1|0|0)
- 1:   abnormal embryonic cloaca morphology [MP:0010115] <5>(0|0) (0|0|0)
- 1:   abnormal pharyngeal pouch morphology [MP:0006031] <5>(1|2) (1|0|0)
- 1:   abnormal germ layer morphology [MP:0014138] <3>(1|3) (1|0|0)
- 1:   abnormal neural fold morphology [MP:0011256] <3>(0|0) (0|0|0)
- 1:   abnormal bilaminar embryonic disc [MP:0012103] <2>(3|3) (3|0|0)
- 1:   abnormal mesonephros morphology [MP:0008487] <2>(3|2) (3|1|0)
- 1:   abnormal anterior definitive endoderm morphology [MP:0008926] <1>(0|0) (0|0|0)
- 1:   abnormal egg cylinder morphology [MP:0003085] <1>(0|0) (0|0|0)
- 1:   abnormal gonadal ridge morphology [MP:0011411] <1>(0|0) (0|0|0)
- 1:   abnormal head fold morphology [MP:0011257] <1>(0|0) (0|0|0)
- 1:   abnormal mesenchyme morphology [MP:0006301] <1>(0|0) (0|0|0)
- 1:   abnormal neural plate morphology [MP:0005657] <1>(0|0) (0|0|0)
- 1:   abnormal pleuropericardial membrane morphology [MP:0012496] <1>(0|0) (0|0|0)
- 1:   abnormal pluripotent precursor cell morphology [MP:0002399] <1>(1|1) (1|0|0)
- 1:   abnormal prechordal plate morphology [MP:0004387] <1>(0|0) (0|0|0)
- 1:   embryo tissue necrosis [MP:0013241] <1>(0|0) (0|0|0)
- 1:   abnormal cervical sinus morphology [MP:0013230](0|0) (0|0|0)
- 1:   abnormal gastrula morphology [MP:3000001](0|0) (0|0|0)
- 1:   abnormal intraembryonic coelom morphology [MP:0012187](0|0) (0|0|0)
- 1:   abnormal pharyngeal groove morphology [MP:0013231](0|0) (0|0|0)
- 1:   abnormal pharyngeal membrane morphology [MP:0013232](0|0) (0|0|0)
- 1:   abnormal septum transversum morphology [MP:0012252](0|0) (0|0|0)
- 1:   abnormal tail fold morphology [MP:0011258](0|0) (0|0|0)
- 1:   abnormal urogenital fold morphology [MP:0011835](0|0) (0|0|0)
- 1:   abnormal urorectal septum morphology [MP:0011853](0|0) (0|0|0)
- 1:   disorganized embryonic tissue [MP:0003988](0|0) (1|0|0)
- 1:   embryo cyst [MP:0014019](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SMAD MH1 domain0.000001199Direct
Frizzled cysteine-rich domain0.0002528Direct
Snake toxin-like0.0008295Direct
Homeodomain-like0.0009669Direct
HCP-like0.003778Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.01539Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1333Inherited
HMG-box0.1511Inherited
Bromodomain0.1782Inherited
Nuclear receptor ligand-binding domain0.1782Inherited
SMAD/FHA domain0.2088Inherited
Ankyrin repeat0.3504Inherited
PDZ domain-like0.4369Inherited
TIMP-like0.4693Inherited
WD40 repeat-like0.8875Inherited
Nucleic acid-binding proteins0.9029Inherited
SAM/Pointed domain0.9746Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
T-box0.0000004737Direct
SMAD MH1 domain0.0000007636Direct
SMAD domain0.0000007636Direct
Homeodomain0.00001181Direct
Extracellular domain of cell surface receptors0.00002049Direct
DIX domain0.00003962Direct
Frizzled cysteine-rich domain0.0001839Direct
Formate/glycerate dehydrogenases, substrate-binding domain0.001563Inherited
C5 cytosine-specific DNA methylase, DCM0.001563Inherited
Formate/glycerate dehydrogenases, NAD-domain0.01161Inherited
Transforming growth factor (TGF)-beta0.06397Inherited
HMG-box0.1302Inherited
Bromodomain0.1549Inherited
Nuclear receptor ligand-binding domain0.1549Inherited
Forkhead DNA-binding domain0.1549Inherited
Nuclear receptor0.1549Inherited
PDZ domain0.244Inherited
Ankyrin repeat0.3256Inherited
SAM (sterile alpha motif) domain0.394Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.4354Inherited
DEP domain0.4354Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SMAD MH1 domain0.0000004901Direct
Frizzled cysteine-rich domain0.000129Direct
Snake toxin-like0.000448Direct
Homeodomain-like0.0005266Direct
HCP-like0.002217Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.009898Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1041Inherited
HMG-box0.1198Inherited
Bromodomain0.1435Inherited
Nuclear receptor ligand-binding domain0.1435Inherited
SMAD/FHA domain0.1713Inherited
Ankyrin repeat0.3051Inherited
FnI-like domain0.3388Inherited
PDZ domain-like0.3895Inherited
TIMP-like0.4215Inherited
BRCT domain0.7052Inherited
WD40 repeat-like0.8596Inherited
Nucleic acid-binding proteins0.8763Inherited
SAM/Pointed domain0.9565Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0007742Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.00086Direct
    48452,81901
  • 48452 - TPR-like
  • 81901 - HCP-like
  • 0.001305Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.004476Inherited
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.009898Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.07285Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.09919Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.4466Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.00002968Direct
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.00086Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.004476Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.07872Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2595Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.8145Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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