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Mammalian Phenotype (MP): abnormal muscle physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   muscle phenotype [MP:0005369] <2>(49|57) (54|37|28)
0:   abnormal muscle physiology [MP:0002106] <23>(25|33) (27|16|11)
- 1:   abnormal muscle regeneration [MP:0000750] <4>(2|2) (2|0|0)
- 1:   abnormal muscle contractility [MP:0005620] <3>(12|15) (13|10|7)
- 1:   abnormal muscle relaxation [MP:0004036] <3>(0|0) (0|0|0)
- 1:   abnormal muscle tone [MP:0004142] <3>(1|2) (1|1|0)
- 1:   abnormal cardiomyocyte apoptosis [MP:0003221] <2>(0|1) (1|0|0)
- 1:   abnormal fetal cardiomyocyte proliferation [MP:0003567] <2>(0|1) (0|0|0)
- 1:   abnormal gastroesophageal sphincter physiology [MP:0010154] <2>(0|0) (0|0|0)
- 1:   abnormal skeletal muscle cell apoptosis [MP:0020239] <2>(0|0) (0|0|0)
- 1:   abnormal vascular smooth muscle physiology [MP:0005595] <2>(3|5) (4|1|0)
- 1:   cardiomyopathy [MP:0005330] <2>(1|2) (1|5|3)
- 1:   muscle weakness [MP:0000747] <2>(1|1) (1|0|0)
- 1:   abnormal muscle cell glucose uptake [MP:0004130] <1>(1|1) (1|0|0)
- 1:   abnormal muscle electrophysiology [MP:0004145] <1>(0|0) (0|0|0)
- 1:   abnormal muscle precursor cell physiology [MP:0012186] <1>(1|1) (1|0|0)
- 1:   abnormal tendon stiffness [MP:0003097] <1>(1|1) (1|0|0)
- 1:   muscle twitch [MP:0009046] <1>(2|2) (2|1|0)
- 1:   abnormal skeletal muscle satellite cell proliferation [MP:0009410](1|1) (1|0|0)
- 1:   diaphragmitis [MP:0013467](0|0) (0|0|0)
- 1:   increased muscle free fatty acid level [MP:0003249](0|0) (0|0|0)
- 1:   muscle fatigue [MP:0003646](0|0) (0|0|0)
- 1:   myopathy [MP:0000751](0|0) (0|0|0)
- 1:   myositis [MP:0004510](0|0) (0|0|0)
- 1:   ophthalmoplegia [MP:0003689](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
MIR domain0.00004622Direct
IP3 receptor type 1 binding core, domain 20.00005721Direct
Voltage-gated potassium channels0.001637Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.001832Inherited
SRF-like0.002161Inherited
WW domain0.02014Inherited
Transducin (alpha subunit), insertion domain0.02376Inherited
Inhibitor of apoptosis (IAP) repeat0.0252Inherited
Nucleotide cyclase0.05968Inherited
BPTI-like0.07275Inherited
Calcium ATPase, transmembrane domain M0.08763Inherited
Calcium ATPase, transduction domain A0.08763Inherited
E set domains0.0948Inherited
POZ domain0.1378Inherited
Lipocalins0.206Inherited
Flavoproteins0.3852Inherited
Myosin rod fragments0.3912Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4685Inherited
Riboflavin synthase domain-like0.4685Inherited
Nuclear receptor ligand-binding domain0.5254Inherited
alpha-catenin/vinculin-like0.6518Inherited
L domain-like0.8596Inherited
HLH, helix-loop-helix DNA-binding domain0.9647Inherited
Homeodomain-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00001957Direct
Calcium ATPase, transmembrane domain M0.00002711Direct
MIR domain0.00003187Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00006115Direct
Metal cation-transporting ATPase, ATP-binding domain N0.0003941Direct
SRF-like0.001533Inherited
Voltage-gated potassium channels0.003153Inherited
Tetramerization domain of potassium channels0.003246Inherited
alpha-catenin/vinculin0.005193Inherited
LIM domain0.007649Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.01029Inherited
Inhibitor of apoptosis (IAP) repeat0.01139Inherited
WW domain0.01787Inherited
Transducin (alpha subunit), insertion domain0.01996Inherited
Adenylyl and guanylyl cyclase catalytic domain0.05236Inherited
Small Kunitz-type inhibitors & BPTI-like toxins0.06234Inherited
Meta-cation ATPase, catalytic domain P0.06658Inherited
Calcium ATPase, transduction domain A0.06658Inherited
Fatty acid binding protein-like0.1723Inherited
Phosphotyrosine-binding domain (PTB)0.2432Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.3441Inherited
Erythroid transcription factor GATA-10.3441Inherited
NADPH-cytochrome p450 reductase-like0.3441Inherited
Cytochrome p450 reductase N-terminal domain-like0.3441Inherited
Myosin rod fragments0.3493Inherited
Nuclear receptor ligand-binding domain0.481Inherited
Nuclear receptor0.481Inherited
L domain0.5127Inherited
HLH, helix-loop-helix DNA-binding domain0.9498Inherited
Ngr ectodomain-like0.9821Inherited
Homeodomain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
MIR domain0.00002163Direct
IP3 receptor type 1 binding core, domain 20.00002692Direct
Voltage-gated potassium channels0.0009213Direct
Metal cation-transporting ATPase, ATP-binding domain N0.001037Inherited
SRF-like0.001233Inherited
WW domain0.01322Inherited
Transducin (alpha subunit), insertion domain0.01581Inherited
Inhibitor of apoptosis (IAP) repeat0.01686Inherited
Nucleotide cyclase0.04294Inherited
BPTI-like0.05341Inherited
Calcium ATPase, transmembrane domain M0.0653Inherited
Calcium ATPase, transduction domain A0.0653Inherited
E set domains0.07111Inherited
POZ domain0.1081Inherited
Lipocalins0.1687Inherited
Flavoproteins0.3388Inherited
Myosin rod fragments0.3447Inherited
Riboflavin synthase domain-like0.4207Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.4207Inherited
Nuclear receptor ligand-binding domain0.4781Inherited
Family A G protein-coupled receptor-like0.5057Inherited
alpha-catenin/vinculin-like0.6085Inherited
dsRNA-binding domain-like0.7053Inherited
L domain-like0.8292Inherited
HLH, helix-loop-helix DNA-binding domain0.9451Inherited
Homeodomain-like1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
100909,49899
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00001247Direct
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.00002692Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0.00002692Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.0007993Direct
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.001037Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.004234Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.004234Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01142Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.08623Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.15Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.1521Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.2739Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.5084Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.5084Inherited
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.6085Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    82109,100909,49899
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.00002692Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0001876Direct
    90257,90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.0001908Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0007993Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.001037Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.002139Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.004234Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.004234Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.5084Inherited
    47220,47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.6085Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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