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Mammalian Phenotype (MP): abnormal axial skeleton morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   skeleton phenotype [MP:0005390] <2>(46|63) (50|41|26)
+ 1:   abnormal skeleton morphology [MP:0005508] <15>(41|59) (47|38|25)
0:   abnormal axial skeleton morphology [MP:0002114] <4>(24|40) (25|21|14)
- 1:   abnormal vertebral column morphology [MP:0004703] <9>(14|16) (15|11|5)
- 1:   abnormal thoracic cage morphology [MP:0004624] <8>(6|9) (8|3|1)
- 1:   abnormal craniofacial bone morphology [MP:0002116] <3>(16|25) (16|13|7)
- 1:   axial skeleton hypoplasia [MP:0000071](0|1) (0|1|1)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Homeodomain-like0.000003514Direct
Clc chloride channel0.01723Inherited
Cystine-knot cytokines0.0372Inherited
FnI-like domain0.085Inherited
Glycosyl hydrolase domain0.102Inherited
Bromodomain0.1366Inherited
Transducin (alpha subunit), insertion domain0.1495Inherited
SCOP hierarchy in SUPERFAMILY0.1974Inherited
HMG-box0.2121Inherited
EGF/Laminin0.2432Inherited
TB module/8-cys domain0.2598Inherited
Kazal-type serine protease inhibitors0.2672Inherited
p53-like transcription factors0.2965Inherited
Growth factor receptor domain0.3153Inherited
PGBD-like0.4063Inherited
Metalloproteases ("zincins"), catalytic domain0.4205Inherited
(Trans)glycosidases0.5289Inherited
Nuclear receptor ligand-binding domain0.5917Inherited
Hemopexin-like domain0.5978Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.6165Inherited
lambda repressor-like DNA-binding domains0.6868Inherited
4-helical cytokines0.8806Inherited
TIMP-like0.9614Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
RUNT domain0Direct
Clathrin adaptor appendage, alpha and beta chain-specific domain0Direct
Alpha-adaptin ear subdomain-like0Direct
p53 tetramerization domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Homeodomain0.000000634Direct
Paired domain0.00002949Direct
DIX domain0.0001411Direct
Notch domain0.000716Direct
Extracellular domain of cell surface receptors0.001103Inherited
MBT repeat0.002794Inherited
Laminin-type module0.003196Inherited
Clc chloride channel0.01321Inherited
Neutral endopeptidase (neprilysin)0.04016Inherited
VWC domain0.07112Inherited
Transforming growth factor (TGF)-beta0.08123Inherited
Laminin G-like module0.09338Inherited
I set domains0.1197Inherited
Bromodomain0.1198Inherited
Transducin (alpha subunit), insertion domain0.1293Inherited
Arylsulfatase0.1739Inherited
EF-hand modules in multidomain proteins0.1842Inherited
HMG-box0.1931Inherited
TB module/8-cys domain0.2332Inherited
Forkhead DNA-binding domain0.236Inherited
DEATH domain, DD0.2439Inherited
Growth factor receptor domain0.2836Inherited
SAM (sterile alpha motif) domain0.3017Inherited
TNF receptor-like0.3064Inherited
HLH, helix-loop-helix DNA-binding domain0.32Inherited
MMP N-terminal domain0.3808Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.3808Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.3808Inherited
Matrix metalloproteases, catalytic domain0.3808Inherited
G proteins0.3996Inherited
T-box0.4156Inherited
Hemopexin-like domain0.5761Inherited
Nuclear receptor ligand-binding domain0.5774Inherited
Nuclear receptor0.5774Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Homeodomain-like0.000001496Direct
Notch domain0.0005869Direct
Clc chloride channel0.01121Inherited
Cystine-knot cytokines0.02567Inherited
FnI-like domain0.06312Inherited
Glycosyl hydrolase domain0.07716Inherited
Bromodomain0.107Inherited
Transducin (alpha subunit), insertion domain0.1182Inherited
HMG-box0.1743Inherited
EGF/Laminin0.2035Inherited
TB module/8-cys domain0.2188Inherited
Kazal-type serine protease inhibitors0.2258Inherited
p53-like transcription factors0.2533Inherited
Growth factor receptor domain0.2712Inherited
HLH, helix-loop-helix DNA-binding domain0.2835Inherited
PGBD-like0.3594Inherited
Metalloproteases ("zincins"), catalytic domain0.3737Inherited
(Trans)glycosidases0.4818Inherited
Nuclear receptor ligand-binding domain0.5457Inherited
Hemopexin-like domain0.5522Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.5713Inherited
lambda repressor-like DNA-binding domains0.6452Inherited
4-helical cytokines0.8521Inherited
TIMP-like0.9414Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.002315Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.002948Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.009575Inherited
    63748,63748
  • 63748 - Tudor/PWWP/MBT
  • 63748 - Tudor/PWWP/MBT
  • 0.02938Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.07716Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.08769Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.1029Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.1609Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1609Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.2188Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.2646Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.2966Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.2966Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3535Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.3594Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.3594Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.408Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.448Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.5482Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0001108Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0009335Direct
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.002315Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.009575Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.06954Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0866Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0866Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.0866Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2966Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.2966Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.2966Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2966Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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