SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal lipid homeostasis

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ 1:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
0:   abnormal lipid homeostasis [MP:0002118] <9>(25|29) (29|17|10)
- 1:   abnormal lipid level [MP:0001547] <16>(24|28) (26|16|10)
- 1:   abnormal circulating ketone body level [MP:0003457] <2>(1|0) (1|1|0)
- 1:   abnormal intestinal lipid absorption [MP:0005342] <2>(0|1) (0|0|0)
- 1:   abnormal lipolysis [MP:0008032] <2>(0|0) (0|0|0)
- 1:   abnormal bile salt homeostasis [MP:0005365] <1>(1|2) (2|1|0)
- 1:   abnormal cholesterol homeostasis [MP:0005278] <1>(11|12) (13|10|8)
- 1:   abnormal lipid oxidation [MP:0010951] <1>(0|0) (0|0|0)
- 1:   decreased susceptibility to hyperlipidemia [MP:0002323](0|0) (0|0|0)
- 1:   xanthoma [MP:0003692](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Nuclear receptor ligand-binding domain0.00000002466Direct
Bet v1-like0.0001094Direct
Thioesterase/thiol ester dehydrase-isomerase0.0001129Direct
FAD-binding/transporter-associated domain-like0.0006365Direct
Apolipoprotein A-I0.0006365Direct
alpha/beta-Hydrolases0.0007693Direct
Cytochrome P4500.0008463Direct
Lipocalins0.004975Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.004991Inherited
ClpP/crotonase0.006112Inherited
Flavoproteins0.006112Inherited
YWTD domain0.007398Inherited
Multidrug efflux transporter AcrB transmembrane domain0.01553Inherited
DHS-like NAD/FAD-binding domain0.0208Inherited
Serum albumin-like0.03816Inherited
Aquaporin-like0.04257Inherited
STAT0.04575Inherited
Transcription factor STAT-4 N-domain0.04575Inherited
Riboflavin synthase domain-like0.1231Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1231Inherited
CAD & PB1 domains0.1433Inherited
Family A G protein-coupled receptor-like0.1902Inherited
Actin-like ATPase domain0.2397Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
HCDH C-domain-like0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Apolipoprotein A-I0Direct
Nuclear receptor ligand-binding domain0.00000001046Direct
Nuclear receptor0.00000007825Direct
Pancreatic lipase, N-terminal domain0.00001065Direct
ABC transporter ATPase domain-like0.00009407Direct
Cytochrome b50.0003218Direct
Cytochrome P4500.0004676Direct
Acetyl-CoA synthetase-like0.0009044Direct
Crotonase-like0.002167Inherited
Fatty acid binding protein-like0.002874Inherited
YWTD domain0.0053Inherited
CAD domain0.007216Inherited
NADPH-cytochrome p450 reductase-like0.01044Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01044Inherited
Sir2 family of transcriptional regulators0.01418Inherited
ABC transporter transmembrane region0.0239Inherited
Serum albumin-like0.02704Inherited
Aquaporin-like0.03033Inherited
STAT DNA-binding domain0.03287Inherited
Transcription factor STAT-4 N-domain0.03287Inherited
STAT0.03287Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.06851Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1895Inherited
Rhodopsin-like0.1999Inherited
EGF-type module0.6396Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Nuclear receptor ligand-binding domain0.000000009383Direct
Bet v1-like0.00005322Direct
Thioesterase/thiol ester dehydrase-isomerase0.0000551Direct
Apolipoprotein A-I0.0003395Direct
FAD-binding/transporter-associated domain-like0.0003395Direct
alpha/beta-Hydrolases0.0004142Direct
Cytochrome P4500.0004578Direct
Phospholipase A2, PLA20.0007937Direct
Acetyl-CoA synthetase-like0.0008737Direct
Lipocalins0.00298Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.002989Inherited
Flavoproteins0.003703Inherited
ClpP/crotonase0.003703Inherited
YWTD domain0.004547Inherited
Multidrug efflux transporter AcrB transmembrane domain0.009991Inherited
DHS-like NAD/FAD-binding domain0.01369Inherited
ABC transporter transmembrane region0.02043Inherited
Serum albumin-like0.02638Inherited
Aquaporin-like0.02969Inherited
STAT0.03213Inherited
Transcription factor STAT-4 N-domain0.03213Inherited
Riboflavin synthase domain-like0.09519Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.09519Inherited
CAD & PB1 domains0.1128Inherited
Family A G protein-coupled receptor-like0.1543Inherited
Actin-like ATPase domain0.2001Inherited
P-loop containing nucleoside triphosphate hydrolases0.8779Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00001572Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.003703Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.009991Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02043Inherited
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.02638Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.03213Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.03213Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.03213Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.03213Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.04433Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.06692Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.1128Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.155Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.155Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.009991Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.009991Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.009991Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.02638Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.02668Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.03213Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.03213Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.06692Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)