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Mammalian Phenotype (MP): abnormal lipid homeostasis

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ 1:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
0:   abnormal lipid homeostasis [MP:0002118] <9>(25|29) (29|17|10)
- 1:   abnormal lipid level [MP:0001547] <16>(24|28) (26|16|10)
- 1:   abnormal circulating ketone body level [MP:0003457] <2>(1|0) (1|1|0)
- 1:   abnormal intestinal lipid absorption [MP:0005342] <2>(0|1) (0|0|0)
- 1:   abnormal lipolysis [MP:0008032] <2>(0|0) (0|0|0)
- 1:   abnormal bile salt homeostasis [MP:0005365] <1>(1|2) (2|1|0)
- 1:   abnormal cholesterol homeostasis [MP:0005278] <1>(11|12) (13|10|8)
- 1:   abnormal lipid oxidation [MP:0010951] <1>(0|0) (0|0|0)
- 1:   decreased susceptibility to hyperlipidemia [MP:0002323](0|0) (0|0|0)
- 1:   xanthoma [MP:0003692](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Nuclear receptor ligand-binding domain0.00000002484Direct
Bet v1-like0.0001097Direct
Thioesterase/thiol ester dehydrase-isomerase0.0001129Direct
FAD-binding/transporter-associated domain-like0.0006369Direct
Apolipoprotein A-I0.0006369Direct
alpha/beta-Hydrolases0.0007729Direct
Cytochrome P4500.0008494Direct
Lipocalins0.004986Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.005Inherited
ClpP/crotonase0.006121Inherited
Flavoproteins0.006121Inherited
YWTD domain0.0074Inherited
Multidrug efflux transporter AcrB transmembrane domain0.01555Inherited
DHS-like NAD/FAD-binding domain0.02083Inherited
Serum albumin-like0.03818Inherited
Aquaporin-like0.04263Inherited
STAT0.0458Inherited
Transcription factor STAT-4 N-domain0.0458Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1232Inherited
Riboflavin synthase domain-like0.1232Inherited
CAD & PB1 domains0.1434Inherited
Family A G protein-coupled receptor-like0.1908Inherited
Actin-like ATPase domain0.2398Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
HCDH C-domain-like0Direct
Apolipoprotein A-I0Direct
Nuclear receptor ligand-binding domain0.00000001054Direct
Nuclear receptor0.00000007888Direct
Pancreatic lipase, N-terminal domain0.00001067Direct
ABC transporter ATPase domain-like0.00009451Direct
Cytochrome b50.0003218Direct
Cytochrome P4500.0004694Direct
Acetyl-CoA synthetase-like0.0009057Direct
Crotonase-like0.002166Inherited
Fatty acid binding protein-like0.00288Inherited
YWTD domain0.0053Inherited
CAD domain0.007213Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01045Inherited
NADPH-cytochrome p450 reductase-like0.01045Inherited
Sir2 family of transcriptional regulators0.0142Inherited
ABC transporter transmembrane region0.02394Inherited
Serum albumin-like0.02707Inherited
Aquaporin-like0.03036Inherited
STAT DNA-binding domain0.03288Inherited
STAT0.03288Inherited
Transcription factor STAT-4 N-domain0.03288Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.06855Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1897Inherited
Rhodopsin-like0.2005Inherited
EGF-type module0.6401Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Nuclear receptor ligand-binding domain0.000000009447Direct
Bet v1-like0.00005333Direct
Thioesterase/thiol ester dehydrase-isomerase0.0000551Direct
Apolipoprotein A-I0.0003397Direct
FAD-binding/transporter-associated domain-like0.0003397Direct
alpha/beta-Hydrolases0.000416Direct
Cytochrome P4500.0004595Direct
Phospholipase A2, PLA20.0007939Direct
Acetyl-CoA synthetase-like0.000875Direct
Lipocalins0.002987Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.002995Inherited
ClpP/crotonase0.003707Inherited
Flavoproteins0.003707Inherited
YWTD domain0.004548Inherited
Multidrug efflux transporter AcrB transmembrane domain0.01Inherited
DHS-like NAD/FAD-binding domain0.01371Inherited
ABC transporter transmembrane region0.02045Inherited
Serum albumin-like0.02639Inherited
Aquaporin-like0.02973Inherited
STAT0.03216Inherited
Transcription factor STAT-4 N-domain0.03216Inherited
Riboflavin synthase domain-like0.09527Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.09527Inherited
CAD & PB1 domains0.1129Inherited
Family A G protein-coupled receptor-like0.1549Inherited
Actin-like ATPase domain0.2002Inherited
P-loop containing nucleoside triphosphate hydrolases0.8781Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00001579Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.003707Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.01Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02045Inherited
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.02639Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.03216Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.03216Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.03216Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.03216Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.04438Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.06698Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.1129Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1552Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.1552Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.01Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.01Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.01Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.02639Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.02672Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.03216Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.03216Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.06698Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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