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Mammalian Phenotype (MP): abnormal definitive hematopoiesis

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + 3:   abnormal hematopoietic cell morphology [MP:0013656] <9>(48|77) (60|43|18)
+ + + 3:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(57|86) (66|47|21)
+ + 2:   abnormal blood cell morphology [MP:0013657] <4>(31|49) (37|35|14)
+ + 2:   abnormal blood cell morphology/development [MP:0002429] <3>(26|35) (28|24|9)
+ 1:   abnormal hemopoiesis [MP:0013693] <2>(25|34) (27|24|9)
0:   abnormal definitive hematopoiesis [MP:0002123] <4>(24|34) (26|24|9)
- 1:   abnormal leukopoiesis [MP:0005460] <3>(17|28) (21|18|8)
- 1:   abnormal common myeloid progenitor cell morphology [MP:0006410] <2>(1|1) (1|2|0)
- 1:   abnormal erythropoiesis [MP:0000245](0|0) (0|0|0)
- 1:   extramedullary hematopoiesis [MP:0000240](2|2) (2|1|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
SH2 domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
PsbU/PolX domain-like0Direct
p53-like transcription factors0.000000001418Direct
4-helical cytokines0.000007343Direct
TNF receptor-like0.00000814Direct
DNA polymerase beta, N-terminal domain-like0.0004025Direct
DEATH domain0.00085Direct
Cyclin-like0.0009463Direct
BRCT domain0.001416Inherited
Bcl-2 inhibitors of programmed cell death0.00188Inherited
Cysteine-rich domain0.002197Inherited
E2F-DP heterodimerization region0.003841Inherited
Notch domain0.007395Inherited
DNA/RNA polymerases0.03881Inherited
Nucleotidyltransferase0.0647Inherited
SH3-domain0.1058Inherited
SET domain0.136Inherited
DBL homology domain (DH-domain)0.2774Inherited
Ankyrin repeat0.3Inherited
Calponin-homology domain, CH-domain0.6777Inherited
SMAD/FHA domain0.882Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
RUNT domain0Direct
STAT DNA-binding domain0Direct
STAT0Direct
SH2 domain0Direct
DNA polymerase beta-like, second domain0Direct
Transcription factor STAT-4 N-domain0Direct
DNA polymerase beta-like0Direct
Short-chain cytokines0.00000008833Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000008438Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.000005876Direct
TNF receptor-like0.00003127Direct
ets domain0.0002295Direct
V set domains (antibody variable domain-like)0.0002626Direct
DNA polymerase beta, N-terminal domain-like0.0002685Direct
PLC-like (P variant)0.0008251Direct
E2F dimerization segment0.001096Inherited
Cyclin0.001103Inherited
Bcl-2 inhibitors of programmed cell death0.00137Inherited
DEATH domain, DD0.001453Inherited
Pointed domain0.002811Inherited
Notch domain0.005455Inherited
Pleckstrin-homology domain (PH domain)0.009565Inherited
Cell cycle transcription factor e2f-dp0.009923Inherited
DNA polymerase I0.01194Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.02115Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.02221Inherited
MATH domain0.08425Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.09674Inherited
SH3-domain0.1129Inherited
FHA domain0.1789Inherited
DBL homology domain (DH-domain)0.2704Inherited
Ankyrin repeat0.3003Inherited
Calponin-homology domain, CH-domain0.6728Inherited
Myb/SANT domain0.9223Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
SH2 domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
p53-like transcription factors0.0000000005279Direct
4-helical cytokines0.000003175Direct
TNF receptor-like0.000003542Direct
DNA polymerase beta, N-terminal domain-like0.0002103Direct
DEATH domain0.00046Direct
Cyclin-like0.0005142Direct
BRCT domain0.0007906Direct
Bcl-2 inhibitors of programmed cell death0.001065Inherited
Cysteine-rich domain0.001252Inherited
E2F-DP heterodimerization region0.002258Inherited
Notch domain0.004544Inherited
DNA/RNA polymerases0.02685Inherited
Nucleotidyltransferase0.04693Inherited
SH3-domain0.08039Inherited
SET domain0.1065Inherited
DBL homology domain (DH-domain)0.2355Inherited
Ankyrin repeat0.2568Inherited
Acyl-CoA N-acyltransferases (Nat)0.4238Inherited
beta-beta-alpha zinc fingers0.585Inherited
Calponin-homology domain, CH-domain0.6357Inherited
SMAD/FHA domain0.8537Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00000002276Direct
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0000001936Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000005056Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.000003371Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00002486Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.00003045Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0001039Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.0001779Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0008748Direct
    56112,56112
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.001065Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.001065Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.001326Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.001326Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.002258Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.02844Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.2052Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.6601Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00001719Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.001326Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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