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Mammalian Phenotype (MP): abnormal cardiovascular system morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   cardiovascular system phenotype [MP:0005385] <2>(67|85) (77|57|35)
0:   abnormal cardiovascular system morphology [MP:0002127] <7>(48|65) (53|44|33)
- 1:   abnormal blood vessel morphology [MP:0001614] <29>(31|38) (36|27|24)
- 1:   abnormal heart morphology [MP:0000266] <22>(27|44) (28|25|19)
- 1:   aneurysm [MP:0003279] <12>(4|3) (4|3|3)
- 1:   abnormal cardiovascular development [MP:0002925] <10>(16|35) (25|19|9)
- 1:   increased cardiovascular system tumor incidence [MP:0010291] <3>(0|0) (0|0|0)
- 1:   peliosis [MP:0013332] <2>(0|0) (0|0|0)
- 1:   decreased cardiovascular system tumor incidence [MP:0012419](0|0) (0|0|0)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
SRF-like0Direct
Tubby C-terminal domain-like0Direct
SMAD MH1 domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
FnI-like domain0.00003466Direct
Calcium-dependent phosphotriesterase0.001745Inherited
Growth factor receptor domain0.003503Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.005202Inherited
Riboflavin synthase domain-like0.005202Inherited
Notch domain0.005708Inherited
EGF/Laminin0.005893Inherited
Cytokine0.006319Inherited
Integrin beta tail domain0.006659Inherited
Kringle-like0.008046Inherited
Spectrin repeat0.01232Inherited
Snake toxin-like0.01676Inherited
Inhibitor of apoptosis (IAP) repeat0.03904Inherited
Flavoproteins0.03904Inherited
Cystine-knot cytokines0.07226Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1042Inherited
Orange domain-like0.1381Inherited
Protein kinase-like (PK-like)0.1601Inherited
Homeodomain-like0.1665Inherited
Frizzled cysteine-rich domain0.1799Inherited
Metalloproteases ("zincins"), catalytic domain0.184Inherited
Tetraspanin0.2121Inherited
Nuclear receptor ligand-binding domain0.225Inherited
Blood coagulation inhibitor (disintegrin)0.2302Inherited
Myosin rod fragments0.2466Inherited
PGBD-like0.2466Inherited
Trypsin-like serine proteases0.2776Inherited
Integrin domains0.3102Inherited
HLH, helix-loop-helix DNA-binding domain0.3168Inherited
YWTD domain0.3388Inherited
Clavaminate synthase-like0.3502Inherited
Fibronectin type III0.4251Inherited
p53-like transcription factors0.5065Inherited
alpha-catenin/vinculin-like0.5446Inherited
Regulator of G-protein signaling, RGS0.5517Inherited
Hemopexin-like domain0.5531Inherited
SH3-domain0.5981Inherited
PYP-like sensor domain (PAS domain)0.6513Inherited
TB module/8-cys domain0.679Inherited
Interleukin 8-like chemokines0.6977Inherited
Glycosyl hydrolase domain0.7452Inherited
"Winged helix" DNA-binding domain0.7754Inherited
cAMP-binding domain-like0.9909Inherited
E set domains0.9994Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Transcriptional factor tubby, C-terminal domain0Direct
SMAD MH1 domain0Direct
Retinoblastoma tumor suppressor domains0Direct
SMAD domain0Direct
SRF-like0Direct
Interleukin-1 (IL-1)0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Growth factor receptor domain0.000000008054Direct
Extracellular domain of cell surface receptors0.0001609Direct
L domain0.0003515Direct
VWC domain0.0005249Direct
DIX domain0.001218Inherited
Integrin beta EGF-like domains0.001636Inherited
T-box0.001921Inherited
Spectrin repeat0.003114Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.004114Inherited
Notch domain0.004114Inherited
NADPH-cytochrome p450 reductase-like0.004114Inherited
Pointed domain0.004947Inherited
Integrin beta tail domain0.004947Inherited
ZZ domain0.01239Inherited
Inhibitor of apoptosis (IAP) repeat0.01415Inherited
Kringle modules0.02249Inherited
EGF-type module0.03005Inherited
alpha-catenin/vinculin0.03837Inherited
Transforming growth factor (TGF)-beta0.07393Inherited
Fibroblast growth factors (FGF)0.1034Inherited
Hairy Orange domain0.1199Inherited
ets domain0.1263Inherited
Protein kinases, catalytic subunit0.1315Inherited
Forkhead DNA-binding domain0.1366Inherited
Frizzled cysteine-rich domain0.1497Inherited
Nuclear receptor ligand-binding domain0.193Inherited
Nuclear receptor0.193Inherited
HMG-box0.2089Inherited
MMP N-terminal domain0.2126Inherited
Myosin rod fragments0.2126Inherited
Cyclin0.2146Inherited
Blood coagulation inhibitor (disintegrin)0.2146Inherited
Homeodomain0.2222Inherited
Integrin domains0.2736Inherited
HLH, helix-loop-helix DNA-binding domain0.2806Inherited
Platelet-derived growth factor-like0.3008Inherited
YWTD domain0.3008Inherited
Reprolysin-like0.3389Inherited
Ras-binding domain, RBD0.3563Inherited
Erythroid transcription factor GATA-10.3581Inherited
Histone deacetylase, HDAC0.3581Inherited
LIM domain0.3792Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.4253Inherited
DEP domain0.4253Inherited
Eukaryotic proteases0.434Inherited
Fibronectin type III0.4552Inherited
DBL homology domain (DH-domain)0.4571Inherited
Matrix metalloproteases, catalytic domain0.4571Inherited
Linker histone H1/H50.5063Inherited
Regulator of G-protein signaling, RGS0.5138Inherited
Hemopexin-like domain0.5145Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.5145Inherited
SH3-domain0.6314Inherited
TB module/8-cys domain0.6445Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.6445Inherited
Interleukin 8-like chemokines0.6897Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.7774Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Tubby C-terminal domain-like0Direct
SRF-like0Direct
SMAD MH1 domain0Direct
FnI-like domain0.000016Direct
Calcium-dependent phosphotriesterase0.0009856Direct
Growth factor receptor domain0.002052Inherited
Riboflavin synthase domain-like0.003123Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.003123Inherited
Notch domain0.003438Inherited
EGF/Laminin0.003553Inherited
Cytokine0.00384Inherited
Integrin beta tail domain0.004059Inherited
Kringle-like0.004952Inherited
Spectrin repeat0.007816Inherited
Snake toxin-like0.01086Inherited
Inhibitor of apoptosis (IAP) repeat0.02702Inherited
Flavoproteins0.02702Inherited
Cystine-knot cytokines0.05303Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.07901Inherited
Orange domain-like0.1084Inherited
Protein kinase-like (PK-like)0.1276Inherited
Homeodomain-like0.133Inherited
Frizzled cysteine-rich domain0.1451Inherited
Metalloproteases ("zincins"), catalytic domain0.1489Inherited
Tetraspanin0.1744Inherited
Nuclear receptor ligand-binding domain0.1866Inherited
Blood coagulation inhibitor (disintegrin)0.1913Inherited
HMG-box0.2026Inherited
Myosin rod fragments0.2067Inherited
PGBD-like0.2067Inherited
Trypsin-like serine proteases0.2356Inherited
Integrin domains0.2665Inherited
HLH, helix-loop-helix DNA-binding domain0.2727Inherited
YWTD domain0.2937Inherited
Clavaminate synthase-like0.3048Inherited
Fibronectin type III0.3785Inherited
DBL homology domain (DH-domain)0.4114Inherited
p53-like transcription factors0.459Inherited
alpha-catenin/vinculin-like0.4978Inherited
Regulator of G-protein signaling, RGS0.5049Inherited
Hemopexin-like domain0.5063Inherited
SH3-domain0.5525Inherited
4-helical cytokines0.555Inherited
PYP-like sensor domain (PAS domain)0.608Inherited
TB module/8-cys domain0.637Inherited
Interleukin 8-like chemokines0.6566Inherited
Glycosyl hydrolase domain0.7068Inherited
"Winged helix" DNA-binding domain0.7387Inherited
Ankyrin repeat0.8204Inherited
cAMP-binding domain-like0.9758Inherited
E set domains0.9865Inherited
PH domain-like0.9926Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00007261Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0002746Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0002746Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.001007Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.0013Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.004059Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.004059Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.004059Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.004351Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.01031Inherited
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0.01141Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.01141Inherited
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0.02065Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.02065Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.02702Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.0339Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.0339Inherited
    49854,49854
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0.05648Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.08477Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.1016Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1017Inherited
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.1084Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.1215Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1511Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1646Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.1913Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.2067Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.2067Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.2573Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.265Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.2937Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.3159Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.3545Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.4176Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.4176Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.4176Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.4176Inherited
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.4978Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.5049Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.5063Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.637Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.7068Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0002746Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0004255Direct
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.0009856Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.002465Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.003438Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.003438Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.003438Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.003438Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.004059Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.004059Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01086Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.01197Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.01197Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.0339Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.0339Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04878Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.06683Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.2067Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2067Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2458Inherited
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.3498Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.3498Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.3498Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.3767Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.4176Inherited
    47220,47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.4978Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.4978Inherited
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.4978Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.608Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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