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Mammalian Phenotype (MP): abnormal respiratory system morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   respiratory system phenotype [MP:0005388] <2>(33|46) (36|29|15)
0:   abnormal respiratory system morphology [MP:0002132] <12>(22|34) (27|22|13)
- 1:   abnormal lung morphology [MP:0001175] <18>(15|25) (17|18|12)
- 1:   abnormal trachea morphology [MP:0002282] <12>(1|1) (3|1|0)
- 1:   abnormal nose morphology [MP:0002233] <9>(2|2) (2|0|0)
- 1:   abnormal respiratory epithelium morphology [MP:0010942] <8>(4|3) (4|2|0)
- 1:   abnormal larynx morphology [MP:0002249] <6>(2|2) (2|1|0)
- 1:   abnormal pharynx morphology [MP:0002234] <6>(0|0) (0|0|0)
- 1:   abnormal paranasal sinus morphology [MP:0002240] <4>(0|0) (0|0|0)
- 1:   abnormal respiratory system development [MP:0003115] <3>(3|7) (6|4|6)
- 1:   abnormal pleura morphology [MP:0010820] <2>(0|0) (0|0|0)
- 1:   increased respiratory system tumor incidence [MP:0010298] <1>(2|3) (2|2|0)
- 1:   abnormal pleural cavity morphology [MP:0012684](0|0) (0|0|0)
- 1:   decreased respiratory system tumor incidence [MP:0012425](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Notch domain0.0002779Direct
Flavoproteins0.002738Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0041Inherited
Riboflavin synthase domain-like0.0041Inherited
Growth factor receptor domain0.03882Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.07212Inherited
Kringle-like0.08141Inherited
Protein kinase-like (PK-like)0.08413Inherited
Homeodomain-like0.1217Inherited
PGBD-like0.1444Inherited
Hemopexin-like domain0.1444Inherited
Nuclear receptor ligand-binding domain0.1649Inherited
Integrin alpha N-terminal domain0.1962Inherited
E2F-DP heterodimerization region0.3353Inherited
FnI-like domain0.3796Inherited
Integrin domains0.3969Inherited
TNF receptor-like0.4869Inherited
Trypsin-like serine proteases0.6754Inherited
Family A G protein-coupled receptor-like0.9904Inherited
PH domain-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
RUNT domain0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0001887Direct
Notch domain0.0001887Direct
NADPH-cytochrome p450 reductase-like0.0001887Direct
Erythroid transcription factor GATA-10.004165Inherited
EGF-type module0.04534Inherited
Protein kinases, catalytic subunit0.09539Inherited
Hemopexin-like domain0.1193Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.1193Inherited
MMP N-terminal domain0.1193Inherited
Matrix metalloproteases, catalytic domain0.1193Inherited
Integrin alpha N-terminal domain0.1278Inherited
Nuclear receptor ligand-binding domain0.138Inherited
Nuclear receptor0.138Inherited
LIM domain0.1567Inherited
Homeodomain0.1665Inherited
Forkhead DNA-binding domain0.2008Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2201Inherited
Growth factor receptor domain0.221Inherited
Extracellular domain of cell surface receptors0.2864Inherited
E2F dimerization segment0.2988Inherited
HLH, helix-loop-helix DNA-binding domain0.3418Inherited
Integrin domains0.3612Inherited
TNF receptor-like0.4503Inherited
Short-chain cytokines0.4676Inherited
Phosphotyrosine-binding domain (PTB)0.5084Inherited
Eukaryotic proteases0.6108Inherited
L domain0.7412Inherited
Rhodopsin-like0.9988Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Notch domain0.0001425Direct
FAS1 domain0.0009861Direct
Flavoproteins0.001578Inherited
Riboflavin synthase domain-like0.002422Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.002422Inherited
Growth factor receptor domain0.02686Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.0529Inherited
Kringle-like0.06018Inherited
Protein kinase-like (PK-like)0.06241Inherited
Homeodomain-like0.09399Inherited
Hemopexin-like domain0.1138Inherited
PGBD-like0.1138Inherited
Nuclear receptor ligand-binding domain0.1318Inherited
EGF/Laminin0.1405Inherited
"Winged helix" DNA-binding domain0.1486Inherited
Integrin alpha N-terminal domain0.1598Inherited
E2F-DP heterodimerization region0.2904Inherited
HLH, helix-loop-helix DNA-binding domain0.3275Inherited
FnI-like domain0.3335Inherited
Integrin domains0.3503Inherited
Cyclin-like0.4393Inherited
TNF receptor-like0.4393Inherited
Trypsin-like serine proteases0.6333Inherited
Family A G protein-coupled receptor-like0.9752Inherited
PH domain-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0.0009861Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.0009861Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.001058Inherited
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.003433Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.005851Inherited
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.00769Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.08041Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.08041Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1016Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1138Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.1138Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1698Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.1698Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.2128Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2775Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.2904Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.2904Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.2904Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.317Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.7324Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.7324Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0006047Direct
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.001578Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.003283Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.003433Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.00769Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.05552Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.08041Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1138Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.156Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.2128Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.3503Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.481Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.7324Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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