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Mammalian Phenotype (MP): abnormal respiratory system physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   respiratory system phenotype [MP:0005388] <2>(33|46) (36|29|15)
0:   abnormal respiratory system physiology [MP:0002133] <23>(15|21) (16|13|7)
- 1:   abnormal respiration [MP:0001943] <6>(12|15) (13|9|6)
- 1:   abnormal pulmonary circulation [MP:0002295] <4>(2|0) (2|0|0)
- 1:   respiratory system inflammation [MP:0002405] <4>(2|5) (3|1|0)
- 1:   abnormal respiratory epithelium physiology [MP:0014200] <3>(0|0) (0|0|0)
- 1:   abnormal bronchoconstrictive response [MP:0012123] <2>(0|0) (0|0|0)
- 1:   abnormal lung elastance [MP:0011043] <2>(0|0) (0|0|0)
- 1:   abnormal lung tissue damping [MP:0011046] <2>(0|0) (0|0|0)
- 1:   abnormal mucociliary clearance [MP:0001947] <2>(0|0) (0|0|0)
- 1:   abnormal surfactant physiology [MP:0004782] <2>(0|1) (0|0|0)
- 1:   atelectasis [MP:0001177] <2>(0|0) (0|0|0)
- 1:   increased lung apoptosis [MP:0030002] <1>(0|0) (0|0|0)
- 1:   pleural effusion [MP:0010334] <1>(0|0) (0|0|0)
- 1:   pulmonary edema [MP:0003828] <1>(0|0) (0|0|0)
- 1:   pulmonary hyaline membrane formation [MP:0011018] <1>(0|0) (0|0|0)
- 1:   abnormal alveolar macrophage physiology [MP:0014226](0|0) (0|0|0)
- 1:   abnormal lung hysteresivity [MP:0010950](0|0) (0|0|0)
- 1:   aerophagia [MP:0010994](0|0) (0|0|0)
- 1:   choking [MP:0003298](0|0) (0|0|0)
- 1:   emphysema [MP:0001958](0|0) (0|3|2)
- 1:   pneumothorax [MP:0010822](0|0) (0|0|0)
- 1:   resistant to pulmonary hyaline membrane formation [MP:0020041](0|0) (0|0|0)
- 1:   respiratory acidosis [MP:0012550](0|0) (0|0|0)
- 1:   tracheomalacia [MP:0013753](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
L27 domain0.001355Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.00185Inherited
p53-like transcription factors0.0153Inherited
Toll/Interleukin receptor TIR domain0.03886Inherited
4-helical cytokines0.0439Inherited
TNF receptor-like0.2056Inherited
FnI-like domain0.2251Inherited
Kringle-like0.2788Inherited
HLH, helix-loop-helix DNA-binding domain0.2801Inherited
Family A G protein-coupled receptor-like0.3346Inherited
Snake toxin-like0.3842Inherited
Voltage-gated potassium channels0.5541Inherited
DEATH domain0.7311Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
RUNT domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Lamin A/C globular tail domain0Direct
L domain0.000004236Direct
L27 domain0.00106Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.001356Inherited
Phenylalanine metabolism regulatory domain0.001356Inherited
Toll/Interleukin receptor TIR domain0.02915Inherited
Short-chain cytokines0.07726Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.07726Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.1038Inherited
Forkhead DNA-binding domain0.1139Inherited
DEATH domain, DD0.1379Inherited
TNF receptor-like0.1838Inherited
Kringle modules0.1838Inherited
HLH, helix-loop-helix DNA-binding domain0.2741Inherited
Interferons/interleukin-10 (IL-10)0.3251Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.3982Inherited
Rhodopsin-like0.4001Inherited
Growth factor receptor domain0.6071Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
L27 domain0.0007546Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.001048Inherited
p53-like transcription factors0.009834Inherited
Toll/Interleukin receptor TIR domain0.0269Inherited
4-helical cytokines0.03067Inherited
TNF receptor-like0.1684Inherited
FnI-like domain0.1867Inherited
Kringle-like0.2369Inherited
HLH, helix-loop-helix DNA-binding domain0.238Inherited
Family A G protein-coupled receptor-like0.2898Inherited
Snake toxin-like0.3379Inherited
Voltage-gated potassium channels0.5073Inherited
DEATH domain0.6922Inherited
Homeodomain-like0.9809Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.000002501Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.000002501Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.00065Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0.001048Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.001699Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.09227Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1875Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2269Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2395Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2985Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.3056Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.6588Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.000002501Direct
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.01493Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.3056Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.3056Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.3056Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.3726Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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