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Mammalian Phenotype (MP): abnormal hepatobiliary system morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   liver/biliary system phenotype [MP:0005370] <2>(37|39) (41|19|10)
0:   abnormal hepatobiliary system morphology [MP:0002138] <6>(25|32) (28|15|5)
- 1:   abnormal liver morphology [MP:0000598] <26>(23|28) (26|13|5)
- 1:   abnormal biliary tract morphology [MP:0005083] <4>(1|1) (1|0|0)
- 1:   abnormal hepatobiliary system development [MP:0003943] <4>(1|1) (1|0|0)
- 1:   increased hepatobiliary system tumor incidence [MP:0010297] <2>(1|3) (1|1|0)
- 1:   abnormal oval cell morphology [MP:0010040] <1>(0|0) (0|0|0)
- 1:   decreased hepatobiliary system tumor incidence [MP:0012421] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Thioesterase/thiol ester dehydrase-isomerase0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Hairpin loop containing domain-like0Direct
(Trans)glycosidases0.000007151Direct
Acyl-CoA dehydrogenase NM domain-like0.0003343Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.0003343Direct
STAT0.0005306Direct
Transcription factor STAT-4 N-domain0.0005306Direct
Flavoproteins0.0005306Direct
Families 57/38 glycoside transferase middle domain0.0006526Direct
DHS-like NAD/FAD-binding domain0.003157Inherited
HMA, heavy metal-associated domain0.003355Inherited
Multidrug efflux transporter AcrB transmembrane domain0.01134Inherited
ABC transporter transmembrane region0.02509Inherited
Riboflavin synthase domain-like0.04066Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.04066Inherited
Cyclin-like0.05562Inherited
WW domain0.08771Inherited
A DNA-binding domain in eukaryotic transcription factors0.13Inherited
Trypsin-like serine proteases0.4762Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.5179Inherited
Nuclear receptor ligand-binding domain0.5205Inherited
Homeodomain-like0.6811Inherited
Alpha-macroglobulin receptor domain0.7748Inherited
YWTD domain0.7748Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.0003494Direct
STAT DNA-binding domain0.0003494Direct
Transcription factor STAT-4 N-domain0.0003494Direct
Sir2 family of transcriptional regulators0.0003494Direct
STAT0.0003494Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0003494Direct
NADPH-cytochrome p450 reductase-like0.0004226Direct
alpha-mannosidase0.0004226Direct
alpha-mannosidase, domain 20.0004226Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0004226Direct
Fatty acid binding protein-like0.001804Inherited
HMA, heavy metal-associated domain0.002288Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.003653Inherited
Erythroid transcription factor GATA-10.008438Inherited
Forkhead DNA-binding domain0.0198Inherited
p120GAP domain-like0.02239Inherited
Kringle modules0.02348Inherited
ABC transporter transmembrane region0.02881Inherited
WW domain0.07603Inherited
A DNA-binding domain in eukaryotic transcription factors0.113Inherited
Chaperone J-domain0.3251Inherited
ABC transporter ATPase domain-like0.3408Inherited
Eukaryotic proteases0.4646Inherited
Nuclear receptor ligand-binding domain0.4724Inherited
Nuclear receptor0.4989Inherited
YWTD domain0.7398Inherited
Complement components0.7398Inherited
Alpha-macroglobulin receptor domain0.7398Inherited
Homeodomain0.8659Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
Hairpin loop containing domain-like0Direct
(Trans)glycosidases0.000003087Direct
Acyl-CoA dehydrogenase NM domain-like0.0001736Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.0001736Direct
STAT0.0002812Direct
Flavoproteins0.0002812Direct
Transcription factor STAT-4 N-domain0.0002812Direct
Families 57/38 glycoside transferase middle domain0.0003489Direct
DHS-like NAD/FAD-binding domain0.001839Inherited
HMA, heavy metal-associated domain0.001958Inherited
Multidrug efflux transporter AcrB transmembrane domain0.007158Inherited
ABC transporter transmembrane region0.01678Inherited
Riboflavin synthase domain-like0.02828Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.02828Inherited
Cyclin-like0.03968Inherited
Insulin-like0.05618Inherited
WW domain0.0654Inherited
A DNA-binding domain in eukaryotic transcription factors0.1012Inherited
Chaperone J-domain0.2979Inherited
Trypsin-like serine proteases0.4284Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.4704Inherited
Nuclear receptor ligand-binding domain0.473Inherited
EGF/Laminin0.5573Inherited
Homeodomain-like0.6392Inherited
Alpha-macroglobulin receptor domain0.7381Inherited
YWTD domain0.7381Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    57414,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.0001736Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0002812Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0002812Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0002812Direct
    88713,88688
  • 88713 - Glycoside hydrolase/deacetylase
  • 88688 - Families 57/38 glycoside transferase middle domain
  • 0.0003489Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0008187Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01678Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.05204Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.2041Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.3139Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.7381Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.8929Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57414,57440,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0002812Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0002812Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.8929Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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