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Mammalian Phenotype (MP): abnormal B cell differentiation

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + + 8:   mammalian phenotype [MP:0000001] <29>
+ + + + + + + 7:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + + + 6:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(57|86) (66|47|21)
+ + + + + 5:   abnormal blood cell morphology [MP:0013657] <4>(31|49) (37|35|14)
+ + + + + 5:   abnormal hematopoietic cell morphology [MP:0013656] <9>(48|77) (60|43|18)
+ + + + + 5:   abnormal blood cell morphology/development [MP:0002429] <3>(26|35) (28|24|9)
+ + + + + 5:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + 4:   abnormal leukocyte morphology [MP:0008246] <4>(36|62) (47|29|15)
+ + + + 4:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
+ + + + 4:   abnormal hemopoiesis [MP:0013693] <2>(25|34) (27|24|9)
+ + + 3:   abnormal definitive hematopoiesis [MP:0002123] <4>(24|34) (26|24|9)
+ + + 3:   abnormal immune system cell morphology [MP:0000716] <5>(37|63) (48|29|16)
+ + + 3:   abnormal mononuclear cell morphology [MP:0008247] <2>(33|57) (41|28|14)
+ + 2:   abnormal lymphocyte morphology [MP:0002619] <5>(27|46) (33|26|14)
+ + 2:   abnormal leukopoiesis [MP:0005460] <3>(17|28) (21|18|8)
+ 1:   abnormal lymphopoiesis [MP:0002401] <3>(17|25) (21|15|6)
+ 1:   abnormal B cell morphology [MP:0004939] <6>(17|28) (20|11|6)
0:   abnormal B cell differentiation [MP:0002144] <10>(12|17) (13|8|2)
- 1:   abnormal pro-B cell morphology [MP:0005432] <6>(0|1) (0|0|0)
- 1:   abnormal B cell selection [MP:0004942] <2>(0|0) (0|0|0)
- 1:   abnormal immature B cell morphology [MP:0005022] <2>(4|8) (4|6|1)
- 1:   abnormal immunoglobulin V(D)J recombination [MP:0008755] <2>(4|3) (4|2|1)
- 1:   abnormal B cell receptor editing [MP:0008766](0|0) (0|0|0)
- 1:   abnormal class switch recombination [MP:0004816](1|1) (1|0|0)
- 1:   abnormal memory B cell differentiation [MP:0008095](0|0) (0|0|0)
- 1:   abnormal plasma cell differentiation [MP:0008099](0|0) (0|0|0)
- 1:   abnormal somatic hypermutation frequency [MP:0004815](1|0) (1|0|0)
- 1:   arrested B cell differentiation [MP:0001802](1|2) (2|2|1)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
DNA polymerase beta, N-terminal domain-like0.000005103Direct
SET domain0.0008931Direct
DNA/RNA polymerases0.001212Inherited
Nucleotidyltransferase0.002369Inherited
SMAD/FHA domain0.01172Inherited
BRCT domain0.02943Inherited
Bcl-2 inhibitors of programmed cell death0.04628Inherited
SH2 domain0.06777Inherited
DBL homology domain (DH-domain)0.3089Inherited
Calponin-homology domain, CH-domain0.3188Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
DNA polymerase beta-like, second domain0Direct
DNA polymerase beta-like0Direct
DNA polymerase beta, N-terminal domain-like0.000002995Direct
Pointed domain0.00004354Direct
DNA polymerase I0.0004999Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0.0009763Direct
MATH domain0.005383Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.008476Inherited
ets domain0.01598Inherited
Bcl-2 inhibitors of programmed cell death0.03515Inherited
FHA domain0.03515Inherited
SH2 domain0.05696Inherited
DBL homology domain (DH-domain)0.2776Inherited
DEATH domain, DD0.2776Inherited
Calponin-homology domain, CH-domain0.286Inherited
Myb/SANT domain0.286Inherited
Pleckstrin-homology domain (PH domain)0.5935Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
DNA polymerase beta, N-terminal domain-like0.000002179Direct
SET domain0.0004842Direct
DNA/RNA polymerases0.0006688Direct
Nucleotidyltransferase0.001358Inherited
SMAD/FHA domain0.007412Inherited
BRCT domain0.01998Inherited
Bcl-2 inhibitors of programmed cell death0.03257Inherited
SH2 domain0.04938Inherited
SH3-domain0.2036Inherited
DBL homology domain (DH-domain)0.2651Inherited
Calponin-homology domain, CH-domain0.2747Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.001399Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.01577Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.03257Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.04544Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.2651Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)