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Mammalian Phenotype (MP): abnormal reproductive system morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   reproductive system phenotype [MP:0005389] <2>(38|58) (47|18|6)
0:   abnormal reproductive system morphology [MP:0002160] <12>(28|46) (37|15|6)
- 1:   abnormal reproductive system development [MP:0003936] <10>(0|0) (0|0|0)
- 1:   abnormal gametogenesis [MP:0001929] <7>(15|19) (19|3|1)
- 1:   genital wound [MP:0013055] <6>(0|0) (0|0|0)
- 1:   abnormal sex gland morphology [MP:0000653] <5>(20|29) (23|10|2)
- 1:   increased reproductive system tumor incidence [MP:0010287] <4>(3|4) (3|0|0)
- 1:   abnormal inguinal canal morphology [MP:0003673] <3>(0|0) (0|0|0)
- 1:   abnormal perineum morphology [MP:0003315] <3>(0|0) (0|0|0)
- 1:   abnormal sex determination [MP:0002210] <3>(7|18) (12|6|3)
- 1:   abnormal female reproductive system morphology [MP:0001119] <2>(13|22) (17|8|2)
- 1:   abnormal male reproductive system morphology [MP:0001145] <2>(12|18) (15|4|0)
- 1:   decreased reproductive system tumor incidence [MP:0012417] <2>(0|0) (0|0|0)
- 1:   abnormal gubernaculum morphology [MP:0005149](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cysteine-rich DNA binding domain, (DM domain)0.0009057Direct
E2F-DP heterodimerization region0.0009057Direct
PAZ domain0.002424Inherited
The spindle assembly checkpoint protein mad20.00474Inherited
Tudor/PWWP/MBT0.02911Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.104Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.113Inherited
HMG-box0.1248Inherited
Nuclear receptor ligand-binding domain0.1309Inherited
SMAD MH1 domain0.1495Inherited
SMAD/FHA domain0.172Inherited
Nucleic acid-binding proteins0.172Inherited
Protein kinase-like (PK-like)0.1948Inherited
Ribosomal protein S5 domain 2-like0.2551Inherited
Fibronectin type III0.2562Inherited
Bcl-2 inhibitors of programmed cell death0.2597Inherited
Cystine-knot cytokines0.283Inherited
STAT0.3418Inherited
Transcription factor STAT-4 N-domain0.3418Inherited
SAICAR synthase-like0.3418Inherited
LDL receptor-like module0.3686Inherited
4-helical cytokines0.4675Inherited
BAR/IMD domain-like0.6711Inherited
L domain-like0.9423Inherited
Homeodomain-like0.9535Inherited
Immunoglobulin1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Retinoblastoma tumor suppressor domains0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
E2F dimerization segment0.0001195Direct
Cysteine-rich DNA binding domain, (DM domain)0.0005587Direct
DNA repair protein MutS, domain III0.0006266Direct
Extracellular domain of cell surface receptors0.0009289Direct
PAZ domain0.00157Inherited
The spindle assembly checkpoint protein mad20.00313Inherited
DNA gyrase/MutL, second domain0.00313Inherited
DNA gyrase/MutL, N-terminal domain0.00313Inherited
Cell cycle transcription factor e2f-dp0.003469Inherited
Single strand DNA-binding domain, SSB0.006076Inherited
Nuclear receptor coactivator interlocking domain0.01015Inherited
Transforming growth factor (TGF)-beta0.02441Inherited
Nuclear receptor ligand-binding domain0.09743Inherited
HMG-box0.1052Inherited
SMAD MH1 domain0.1176Inherited
SMAD domain0.1176Inherited
Forkhead DNA-binding domain0.1355Inherited
Nuclear receptor0.14Inherited
Insulin-like0.1602Inherited
Protein kinases, catalytic subunit0.1659Inherited
ABC transporter ATPase domain-like0.2119Inherited
Tudor domain0.2119Inherited
Bcl-2 inhibitors of programmed cell death0.2179Inherited
L domain0.2179Inherited
Fibronectin type III0.2369Inherited
Growth factor receptor domain0.2851Inherited
Gonadodropin/Follitropin0.2964Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.2964Inherited
STAT DNA-binding domain0.2964Inherited
NADPH-cytochrome p450 reductase-like0.2964Inherited
STAT0.2964Inherited
Transcription factor STAT-4 N-domain0.2964Inherited
Cytochrome p450 reductase N-terminal domain-like0.2964Inherited
LDL receptor-like module0.3187Inherited
Short-chain cytokines0.5486Inherited
Histone lysine methyltransferases0.5486Inherited
PHD domain0.8008Inherited
Ngr ectodomain-like0.873Inherited
I set domains0.9475Inherited
Homeodomain0.959Inherited
Rhodopsin-like0.9962Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Cysteine-rich DNA binding domain, (DM domain)0.0004918Direct
E2F-DP heterodimerization region0.0004918Direct
DNA repair protein MutS, domain III0.0005582Direct
PAZ domain0.00139Inherited
The spindle assembly checkpoint protein mad20.002827Inherited
Nuclear receptor coactivator interlocking domain0.009241Inherited
Tudor/PWWP/MBT0.01973Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.07885Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.08659Inherited
Ribonuclease H-like0.08802Inherited
HMG-box0.09666Inherited
Nuclear receptor ligand-binding domain0.102Inherited
SMAD MH1 domain0.1182Inherited
SMAD/FHA domain0.138Inherited
Nucleic acid-binding proteins0.138Inherited
Protein kinase-like (PK-like)0.1586Inherited
Insulin-like0.1609Inherited
Cytochrome P4500.1723Inherited
Ribosomal protein S5 domain 2-like0.2144Inherited
Fibronectin type III0.2155Inherited
Bcl-2 inhibitors of programmed cell death0.2187Inherited
dsRNA-binding domain-like0.2187Inherited
Cystine-knot cytokines0.2408Inherited
SAICAR synthase-like0.2965Inherited
STAT0.2965Inherited
Transcription factor STAT-4 N-domain0.2965Inherited
"Winged helix" DNA-binding domain0.3019Inherited
LDL receptor-like module0.3228Inherited
4-helical cytokines0.4196Inherited
Growth factor receptor domain0.4887Inherited
BAR/IMD domain-like0.6287Inherited
L domain-like0.92Inherited
Homeodomain-like0.9324Inherited
Family A G protein-coupled receptor-like0.9826Inherited
Immunoglobulin1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    52058,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0004918Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0005582Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.009241Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.009241Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.2017Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2017Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.211Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.2187Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.2187Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2965Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.2965Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2965Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9324Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,49265
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 0Direct
    52058,49265,49265
  • 52058 - L domain-like
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0Direct
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1297Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.2187Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.2965Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.2965Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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