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Mammalian Phenotype (MP): abnormal gland morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   endocrine/exocrine gland phenotype [MP:0005379] <2>(51|81) (55|36|12)
0:   abnormal gland morphology [MP:0002163] <8>(44|71) (50|31|11)
- 1:   abnormal pancreas morphology [MP:0001944] <17>(7|12) (8|7|4)
- 1:   increased gland tumor incidence [MP:0010288] <15>(6|9) (7|2|0)
- 1:   abnormal exocrine gland morphology [MP:0013558] <13>(18|22) (19|13|8)
- 1:   abnormal bile duct morphology [MP:0002928] <10>(1|1) (1|0|0)
- 1:   abnormal endocrine gland morphology [MP:0013560] <7>(16|29) (21|19|4)
- 1:   abnormal gallbladder morphology [MP:0005084] <6>(0|0) (0|0|0)
- 1:   decreased gland tumor incidence [MP:0012416] <6>(0|0) (0|0|0)
- 1:   abnormal sex gland morphology [MP:0000653] <5>(20|29) (23|10|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Nuclear receptor coactivator interlocking domain0Direct
p53 tetramerization domain0Direct
Hedgehog/DD-peptidase0Direct
Hedgehog/intein (Hint) domain0Direct
Homeodomain-like0.0000000003686Direct
Nuclear receptor ligand-binding domain0.0000006092Direct
p53-like transcription factors0.000009362Direct
Insulin-like0.00005592Direct
SH2 domain0.0001928Direct
SMAD MH1 domain0.0001954Direct
STAT0.0006627Direct
E2F-DP heterodimerization region0.0006627Direct
Transcription factor STAT-4 N-domain0.0006627Direct
HLH, helix-loop-helix DNA-binding domain0.001089Inherited
PAZ domain0.002849Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.002894Inherited
4-helical cytokines0.002931Inherited
HMG-box0.004087Inherited
Notch domain0.006666Inherited
The spindle assembly checkpoint protein mad20.0199Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.06763Inherited
beta-beta-alpha zinc fingers0.115Inherited
Band 7/SPFH domain0.1515Inherited
CCCH zinc finger0.2533Inherited
BRCT domain0.2746Inherited
Cystine-knot cytokines0.2908Inherited
E set domains0.3057Inherited
Rhodanese/Cell cycle control phosphatase0.3261Inherited
RING/U-box0.3485Inherited
WW domain0.3561Inherited
Tudor/PWWP/MBT0.3712Inherited
EGF/Laminin0.3811Inherited
Cysteine-rich domain0.5215Inherited
SMAD/FHA domain0.574Inherited
LDL receptor-like module0.6026Inherited
TNF receptor-like0.6632Inherited
Bcl-2 inhibitors of programmed cell death0.7303Inherited
Intermediate filament protein, coiled coil region0.8033Inherited
Nucleic acid-binding proteins0.8162Inherited
TNF-like0.8964Inherited
Immunoglobulin0.9947Inherited
Family A G protein-coupled receptor-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Hedgehog (development protein), N-terminal signaling domain0Direct
Pointed domain0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
p53 DNA-binding domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
RUNT domain0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
p53 tetramerization domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
E2F dimerization segment0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Homeodomain0.000000008191Direct
Nuclear receptor ligand-binding domain0.0000006649Direct
Nuclear receptor0.00000399Direct
Paired domain0.00003877Direct
Insulin-like0.00003877Direct
SMAD MH1 domain0.0001367Direct
SMAD domain0.0001367Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0002314Direct
SH2 domain0.0002357Direct
STAT DNA-binding domain0.0004696Direct
Transcription factor STAT-4 N-domain0.0004696Direct
L domain0.0004696Direct
STAT0.0004696Direct
CUT domain0.0004696Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0007579Direct
Growth factor receptor domain0.000945Direct
HLH, helix-loop-helix DNA-binding domain0.001281Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.001753Inherited
Transforming growth factor (TGF)-beta0.001883Inherited
PAZ domain0.002141Inherited
HMG-box0.003819Inherited
Short-chain cytokines0.004361Inherited
ets domain0.004657Inherited
Tudor domain0.004929Inherited
Notch domain0.00498Inherited
Cell cycle transcription factor e2f-dp0.005962Inherited
Forkhead DNA-binding domain0.009131Inherited
Extracellular domain of cell surface receptors0.01273Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.0152Inherited
The spindle assembly checkpoint protein mad20.01538Inherited
DNA gyrase/MutL, second domain0.01538Inherited
DNA gyrase/MutL, N-terminal domain0.01538Inherited
DNA polymerase I0.01691Inherited
Single strand DNA-binding domain, SSB0.03683Inherited
Cysteine-rich DNA binding domain, (DM domain)0.03683Inherited
Transducin (alpha subunit), insertion domain0.04249Inherited
Gonadodropin/Follitropin0.04409Inherited
Long-chain cytokines0.07961Inherited
Linker histone H1/H50.1007Inherited
DnaQ-like 3'-5' exonuclease0.1061Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1197Inherited
CCCH zinc finger0.2368Inherited
WW domain0.353Inherited
Cell cycle control phosphatase, catalytic domain0.3758Inherited
Phosphotyrosine-binding domain (PTB)0.3973Inherited
EGF-type module0.5303Inherited
LDL receptor-like module0.5593Inherited
TNF receptor-like0.6242Inherited
Cytochrome P4500.6923Inherited
Bcl-2 inhibitors of programmed cell death0.6938Inherited
FHA domain0.7723Inherited
Papain-like0.7723Inherited
Intermediate filament protein, coiled coil region0.8071Inherited
DEATH domain, DD0.8287Inherited
TNF-like0.8727Inherited
I set domains0.9975Inherited
Rhodopsin-like1Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Hedgehog/intein (Hint) domain0Direct
p53 tetramerization domain0Direct
Hedgehog/DD-peptidase0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Nuclear receptor coactivator interlocking domain0Direct
Homeodomain-like0.0000000001355Direct
Nuclear receptor ligand-binding domain0.0000002457Direct
p53-like transcription factors0.000004096Direct
Insulin-like0.0000263Direct
SH2 domain0.00009718Direct
SMAD MH1 domain0.00009854Direct
STAT0.0003546Direct
E2F-DP heterodimerization region0.0003546Direct
Transcription factor STAT-4 N-domain0.0003546Direct
HLH, helix-loop-helix DNA-binding domain0.0005982Direct
PAZ domain0.00165Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.001676Inherited
4-helical cytokines0.001698Inherited
HMG-box0.002411Inherited
Ribonuclease H-like0.002729Inherited
Notch domain0.004067Inherited
The spindle assembly checkpoint protein mad20.01304Inherited
Cysteine-rich DNA binding domain, (DM domain)0.03134Inherited
Transducin (alpha subunit), insertion domain0.03449Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.04928Inherited
beta-beta-alpha zinc fingers0.08831Inherited
Band 7/SPFH domain0.1201Inherited
"Winged helix" DNA-binding domain0.1439Inherited
CCCH zinc finger0.2128Inherited
BRCT domain0.2328Inherited
Cystine-knot cytokines0.2481Inherited
E set domains0.2622Inherited
Rhodanese/Cell cycle control phosphatase0.2818Inherited
RING/U-box0.3032Inherited
WW domain0.3106Inherited
Tudor/PWWP/MBT0.3253Inherited
EGF/Laminin0.3349Inherited
Cysteine-rich domain0.4741Inherited
SMAD/FHA domain0.5276Inherited
LDL receptor-like module0.5571Inherited
TNF receptor-like0.6207Inherited
Cytochrome P4500.6454Inherited
Bcl-2 inhibitors of programmed cell death0.6913Inherited
Intermediate filament protein, coiled coil region0.7687Inherited
Nucleic acid-binding proteins0.7824Inherited
Protein kinase-like (PK-like)0.8209Inherited
TNF-like0.869Inherited
Immunoglobulin0.9803Inherited
Family A G protein-coupled receptor-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0000649Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0001647Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0003546Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0003546Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0003546Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0003546Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0003546Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0003546Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00165Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.002Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.004067Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01077Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.01304Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02293Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.02455Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.02455Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.02679Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.03086Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.03836Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.07197Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.07479Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.07479Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.2328Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2385Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.5445Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.8191Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9833Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0003546Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0003546Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0003546Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003265Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01234Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01411Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.04977Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.07116Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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