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Mammalian Phenotype (MP): abnormal gland morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   endocrine/exocrine gland phenotype [MP:0005379] <2>(51|81) (55|36|12)
0:   abnormal gland morphology [MP:0002163] <8>(44|71) (50|31|11)
- 1:   abnormal pancreas morphology [MP:0001944] <17>(7|12) (8|7|4)
- 1:   increased gland tumor incidence [MP:0010288] <15>(6|9) (7|2|0)
- 1:   abnormal exocrine gland morphology [MP:0013558] <13>(18|22) (19|13|8)
- 1:   abnormal bile duct morphology [MP:0002928] <10>(1|1) (1|0|0)
- 1:   abnormal endocrine gland morphology [MP:0013560] <7>(16|29) (21|19|4)
- 1:   abnormal gallbladder morphology [MP:0005084] <6>(0|0) (0|0|0)
- 1:   decreased gland tumor incidence [MP:0012416] <6>(0|0) (0|0|0)
- 1:   abnormal sex gland morphology [MP:0000653] <5>(20|29) (23|10|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Hedgehog/DD-peptidase0Direct
Hedgehog/intein (Hint) domain0Direct
p53 tetramerization domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Homeodomain-like0.0000000003715Direct
Nuclear receptor ligand-binding domain0.0000006112Direct
p53-like transcription factors0.000009375Direct
Insulin-like0.00005604Direct
SH2 domain0.0001933Direct
SMAD MH1 domain0.0001954Direct
STAT0.0006631Direct
Transcription factor STAT-4 N-domain0.0006631Direct
E2F-DP heterodimerization region0.0006631Direct
HLH, helix-loop-helix DNA-binding domain0.001092Inherited
PAZ domain0.002849Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.0029Inherited
4-helical cytokines0.002934Inherited
HMG-box0.004089Inherited
Notch domain0.006669Inherited
The spindle assembly checkpoint protein mad20.0199Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.06766Inherited
beta-beta-alpha zinc fingers0.1152Inherited
Band 7/SPFH domain0.1516Inherited
CCCH zinc finger0.2533Inherited
BRCT domain0.2746Inherited
Cystine-knot cytokines0.2907Inherited
E set domains0.3056Inherited
Rhodanese/Cell cycle control phosphatase0.3261Inherited
RING/U-box0.3487Inherited
WW domain0.3561Inherited
Tudor/PWWP/MBT0.3711Inherited
EGF/Laminin0.381Inherited
Cysteine-rich domain0.5215Inherited
SMAD/FHA domain0.5741Inherited
LDL receptor-like module0.6027Inherited
TNF receptor-like0.6633Inherited
Bcl-2 inhibitors of programmed cell death0.7302Inherited
Intermediate filament protein, coiled coil region0.8035Inherited
Nucleic acid-binding proteins0.8161Inherited
TNF-like0.8963Inherited
Immunoglobulin0.993Inherited
Family A G protein-coupled receptor-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
p53 DNA-binding domain-like0Direct
Hedgehog (development protein), N-terminal signaling domain0Direct
Retinoblastoma tumor suppressor domains0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
RUNT domain0Direct
Pointed domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
E2F dimerization segment0Direct
p53 tetramerization domain0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Homeodomain0.000000008247Direct
Nuclear receptor ligand-binding domain0.0000006678Direct
Nuclear receptor0.000004003Direct
Insulin-like0.00003884Direct
Paired domain0.00003884Direct
SMAD MH1 domain0.0001367Direct
SMAD domain0.0001367Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0002314Direct
SH2 domain0.0002364Direct
STAT DNA-binding domain0.0004698Direct
CUT domain0.0004698Direct
L domain0.0004698Direct
STAT0.0004698Direct
Transcription factor STAT-4 N-domain0.0004698Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0007584Direct
Growth factor receptor domain0.0009466Direct
HLH, helix-loop-helix DNA-binding domain0.001284Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.001753Inherited
Transforming growth factor (TGF)-beta0.001886Inherited
PAZ domain0.002142Inherited
HMG-box0.003823Inherited
Short-chain cytokines0.004361Inherited
ets domain0.004661Inherited
Tudor domain0.004933Inherited
Notch domain0.004981Inherited
Cell cycle transcription factor e2f-dp0.005961Inherited
Forkhead DNA-binding domain0.009135Inherited
Extracellular domain of cell surface receptors0.01274Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.01522Inherited
The spindle assembly checkpoint protein mad20.01539Inherited
DNA gyrase/MutL, second domain0.01539Inherited
DNA gyrase/MutL, N-terminal domain0.01539Inherited
DNA polymerase I0.01692Inherited
Cysteine-rich DNA binding domain, (DM domain)0.03683Inherited
Single strand DNA-binding domain, SSB0.03683Inherited
Transducin (alpha subunit), insertion domain0.0425Inherited
Gonadodropin/Follitropin0.0441Inherited
Long-chain cytokines0.07961Inherited
Linker histone H1/H50.1007Inherited
DnaQ-like 3'-5' exonuclease0.1061Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1198Inherited
CCCH zinc finger0.2368Inherited
WW domain0.3531Inherited
Cell cycle control phosphatase, catalytic domain0.3759Inherited
Phosphotyrosine-binding domain (PTB)0.3976Inherited
EGF-type module0.5303Inherited
LDL receptor-like module0.5594Inherited
TNF receptor-like0.6242Inherited
Cytochrome P4500.6924Inherited
Bcl-2 inhibitors of programmed cell death0.6937Inherited
Papain-like0.7722Inherited
FHA domain0.7722Inherited
Intermediate filament protein, coiled coil region0.8073Inherited
DEATH domain, DD0.8287Inherited
TNF-like0.8727Inherited
I set domains0.9975Inherited
Rhodopsin-like1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Hedgehog/DD-peptidase0Direct
p53 tetramerization domain0Direct
Hedgehog/intein (Hint) domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Homeodomain-like0.0000000001366Direct
Nuclear receptor ligand-binding domain0.0000002464Direct
p53-like transcription factors0.000004104Direct
Insulin-like0.00002634Direct
SH2 domain0.00009744Direct
SMAD MH1 domain0.00009854Direct
E2F-DP heterodimerization region0.0003547Direct
STAT0.0003547Direct
Transcription factor STAT-4 N-domain0.0003547Direct
HLH, helix-loop-helix DNA-binding domain0.0005996Direct
PAZ domain0.00165Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.00168Inherited
4-helical cytokines0.001699Inherited
HMG-box0.002413Inherited
Ribonuclease H-like0.002732Inherited
Notch domain0.004068Inherited
The spindle assembly checkpoint protein mad20.01304Inherited
Cysteine-rich DNA binding domain, (DM domain)0.03134Inherited
Transducin (alpha subunit), insertion domain0.03451Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.0493Inherited
beta-beta-alpha zinc fingers0.08847Inherited
Band 7/SPFH domain0.1202Inherited
"Winged helix" DNA-binding domain0.1439Inherited
CCCH zinc finger0.2128Inherited
BRCT domain0.2329Inherited
Cystine-knot cytokines0.248Inherited
E set domains0.2621Inherited
Rhodanese/Cell cycle control phosphatase0.2818Inherited
RING/U-box0.3034Inherited
WW domain0.3106Inherited
Tudor/PWWP/MBT0.3253Inherited
EGF/Laminin0.3348Inherited
Cysteine-rich domain0.474Inherited
SMAD/FHA domain0.5277Inherited
LDL receptor-like module0.557Inherited
TNF receptor-like0.6207Inherited
Cytochrome P4500.6456Inherited
Bcl-2 inhibitors of programmed cell death0.6912Inherited
Intermediate filament protein, coiled coil region0.7688Inherited
Nucleic acid-binding proteins0.7824Inherited
Protein kinase-like (PK-like)0.8208Inherited
TNF-like0.8689Inherited
Immunoglobulin0.9785Inherited
Family A G protein-coupled receptor-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00006494Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0001647Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0003547Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.0003547Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0003547Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0003547Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0003547Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0003547Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00165Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.002001Inherited
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.004068Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.01078Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.01304Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02295Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.02455Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.02455Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.02681Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.03087Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.03836Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.07206Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.0748Inherited
    57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.0748Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.2329Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2386Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.5447Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.819Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9833Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54928,54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0003547Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0003547Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0003547Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003267Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01234Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01413Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.04979Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.07119Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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