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Mammalian Phenotype (MP): abnormal CNS synaptic transmission

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   nervous system phenotype [MP:0003631] <2>(98|128) (113|79|50)
+ + 2:   abnormal nervous system physiology [MP:0003633] <38>(43|60) (52|31|18)
+ 1:   abnormal synaptic transmission [MP:0003635] <8>(23|28) (27|14|6)
0:   abnormal CNS synaptic transmission [MP:0002206] <14>(18|21) (24|14|6)
- 1:   abnormal excitatory postsynaptic currents [MP:0002910] <5>(5|7) (6|5|5)
- 1:   abnormal synaptic depression [MP:0002915] <3>(4|6) (5|3|1)
- 1:   abnormal glutamate-mediated receptor currents [MP:0002886] <2>(3|4) (4|3|1)
- 1:   abnormal long term potentiation [MP:0002207] <2>(4|4) (6|1|0)
- 1:   abnormal post-tetanic potentiation [MP:0002921] <2>(0|0) (0|0|0)
- 1:   abnormal prepulse inhibition [MP:0003088] <2>(1|0) (1|0|0)
- 1:   abnormal GABA-mediated receptor currents [MP:0004008](2|3) (2|2|1)
- 1:   abnormal acid-activated cation-mediated receptor currents [MP:0009244](0|0) (0|0|0)
- 1:   abnormal excitatory postsynaptic potential [MP:0002912](0|0) (0|1|0)
- 1:   abnormal inhibitory postsynaptic currents [MP:0002945](2|4) (3|2|1)
- 1:   abnormal inhibitory postsynaptic potential [MP:0002911](1|1) (1|0|0)
- 1:   abnormal miniature excitatory postsynaptic currents [MP:0004753](0|0) (0|2|0)
- 1:   abnormal miniature inhibitory postsynaptic currents [MP:0009435](0|1) (0|0|0)
- 1:   abnormal nicotine-mediated receptor currents [MP:0009475](2|2) (2|1|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Periplasmic binding protein-like II0.000000000001102Direct
SNF-like0.0006325Direct
SRF-like0.0006879Direct
BAR/IMD domain-like0.02142Inherited
PreATP-grasp domain0.02982Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.03923Inherited
Riboflavin synthase domain-like0.03923Inherited
Zn-dependent exopeptidases0.03938Inherited
Complement control module/SCR domain0.0578Inherited
Periplasmic binding protein-like I0.1458Inherited
Glutathione synthetase ATP-binding domain-like0.1663Inherited
Spermadhesin, CUB domain0.185Inherited
SH3-domain0.3471Inherited
L27 domain0.7403Inherited
Cysteine-rich domain0.7518Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7802Inherited
Nicotinic receptor ligand binding domain-like0.7802Inherited
Voltage-gated potassium channels1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Synapsin C-terminal domain0Direct
Synapsin domain0Direct
Phosphate binding protein-like0.00000000000005888Direct
SRF-like0.0004635Direct
SNF-like0.0004707Direct
Ephrin ectodomain0.0006249Direct
Phosphotyrosine-binding domain (PTB)0.01254Inherited
Acetylcholinesterase-like0.03214Inherited
BAR domain0.03301Inherited
Complement control module/SCR domain0.05164Inherited
SAM (sterile alpha motif) domain0.1631Inherited
L-arabinose binding protein-like0.1749Inherited
Spermadhesin, CUB domain0.175Inherited
SH3-domain0.3164Inherited
Laminin G-like module0.5025Inherited
Pyridoxal-dependent decarboxylase0.7116Inherited
L27 domain0.7116Inherited
YWTD domain0.7116Inherited
Nicotinic receptor ligand binding domain-like0.7579Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7579Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.7618Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Periplasmic binding protein-like II0.0000000000004001Direct
SNF-like0.0003373Direct
SRF-like0.0003675Direct
Cupredoxins0.01326Inherited
BAR/IMD domain-like0.01413Inherited
PreATP-grasp domain0.02027Inherited
Riboflavin synthase domain-like0.02716Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.02716Inherited
Zn-dependent exopeptidases0.02727Inherited
Complement control module/SCR domain0.04142Inherited
Periplasmic binding protein-like I0.115Inherited
Glutathione synthetase ATP-binding domain-like0.1329Inherited
Spermadhesin, CUB domain0.1498Inherited
Concanavalin A-like lectins/glucanases0.2849Inherited
SH3-domain0.3018Inherited
alpha/beta-Hydrolases0.3597Inherited
YWTD domain0.7018Inherited
PLP-dependent transferases0.7018Inherited
L27 domain0.7018Inherited
Cysteine-rich domain0.7137Inherited
Nicotinic receptor ligand binding domain-like0.744Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.744Inherited
Nuclear receptor ligand-binding domain0.8887Inherited
Voltage-gated potassium channels1Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.000003548Direct
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.0003493Direct
    57535,49854
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0.0003675Direct
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.005803Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.01027Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.01426Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.01491Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.09318Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.7018Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.744Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.9502Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    49854,57535,49854
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0.0003675Direct
    57535,49854,57535
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.0003675Direct
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.003095Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.004884Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.104Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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