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Mammalian Phenotype (MP): increased susceptibility to infection

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + 3:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + 2:   abnormal response to infection [MP:0005025] <2>(18|31) (21|17|5)
+ 1:   altered susceptibility to infection [MP:0001793] <8>(18|31) (21|17|5)
0:   increased susceptibility to infection [MP:0002406] <6>(11|19) (12|11|4)
- 1:   increased susceptibility to infection induced morbidity/mortality [MP:0009787] <3>(0|0) (0|0|0)
- 1:   increased susceptibility to viral infection [MP:0002418] <2>(1|3) (1|1|0)
- 1:   increased susceptibility to bacterial infection [MP:0002412] <1>(3|5) (4|4|1)
- 1:   increased susceptibility to parasitic infection [MP:0005027] <1>(0|1) (0|0|0)
- 1:   increased susceptibility to fungal infection [MP:0005399](0|0) (0|0|0)
- 1:   increased susceptibility to prion infection [MP:0005364](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
4-helical cytokines0.00000000001418Direct
Toll/Interleukin receptor TIR domain0.00000000007181Direct
p53-like transcription factors0.0000003077Direct
Triple coiled coil domain of C-type lectins0.0002357Direct
STAT0.0002425Direct
Transcription factor STAT-4 N-domain0.0002425Direct
RNI-like0.0009824Direct
Alpha-macroglobulin receptor domain0.003605Inherited
dsRNA-binding domain-like0.0143Inherited
TNF receptor-like0.502Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Toll/Interleukin receptor TIR domain0.0000000006445Direct
Short-chain cytokines0.000002556Direct
Interleukin 17F, IL-17F0.00001216Direct
Interferons/interleukin-10 (IL-10)0.00004257Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00007402Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00009078Direct
Triple coiled coil domain of C-type lectins0.0001513Direct
STAT DNA-binding domain0.0001615Direct
STAT0.0001615Direct
Transcription factor STAT-4 N-domain0.0001615Direct
Netrin-like domain (NTR/C345C module)0.0005661Direct
Long-chain cytokines0.0007276Direct
Complement components0.002585Inherited
Alpha-macroglobulin receptor domain0.002585Inherited
Double-stranded RNA-binding domain (dsRBD)0.02204Inherited
Interferon regulatory factor0.4074Inherited
TNF receptor-like0.4635Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.4635Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
4-helical cytokines0.000000000005152Direct
Toll/Interleukin receptor TIR domain0.00000000002618Direct
p53-like transcription factors0.0000001234Direct
Triple coiled coil domain of C-type lectins0.0001195Direct
STAT0.0001232Direct
Transcription factor STAT-4 N-domain0.0001232Direct
RNI-like0.0005355Direct
Alpha-macroglobulin receptor domain0.002114Inherited
Integrin alpha N-terminal domain0.006839Inherited
dsRNA-binding domain-like0.009172Inherited
TNF receptor-like0.4544Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.000000925Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00006577Direct
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.0001195Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0001232Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0001232Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0001232Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.003574Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.003574Inherited
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.005507Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.519Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0000504Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0001232Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0001232Direct
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.003574Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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