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Mammalian Phenotype (MP): abnormal adaptive immunity

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ 1:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
0:   abnormal adaptive immunity [MP:0002420] <8>(36|48) (38|33|21)
- 1:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
- 1:   abnormal professional antigen presenting cell physiology [MP:0002452] <3>(25|32) (26|19|12)
- 1:   abnormal type I hypersensitivity reaction [MP:0002531] <2>(1|1) (1|0|0)
- 1:   abnormal type II hypersensitivity reaction [MP:0002532] <2>(0|0) (0|0|0)
- 1:   abnormal type III hypersensitivity reaction [MP:0002533] <2>(0|0) (0|0|0)
- 1:   abnormal type IV hypersensitivity reaction [MP:0002534] <2>(0|1) (0|0|0)
- 1:   abnormal class switch recombination [MP:0004816](1|1) (1|0|0)
- 1:   abnormal somatic hypermutation frequency [MP:0004815](1|0) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
Immunoglobulin0.00008967Direct
SH2 domain0.0001033Direct
DEATH domain0.0003091Direct
SH3-domain0.0003569Direct
p53-like transcription factors0.004461Inherited
DBL homology domain (DH-domain)0.02152Inherited
Toll/Interleukin receptor TIR domain0.03893Inherited
TNF receptor-like0.04112Inherited
Caspase-like0.0655Inherited
MHC antigen-recognition domain0.06827Inherited
Flavoproteins0.08037Inherited
L30e-like0.1156Inherited
Interleukin 8-like chemokines0.1195Inherited
Bcl-2 inhibitors of programmed cell death0.1523Inherited
Cysteine-rich domain0.1682Inherited
Inhibitor of apoptosis (IAP) repeat0.2005Inherited
DNA/RNA polymerases0.2005Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.263Inherited
4-helical cytokines0.3051Inherited
E set domains0.3183Inherited
Integrin domains0.3429Inherited
WWE domain0.3454Inherited
TNF-like0.3789Inherited
Family A G protein-coupled receptor-like0.3804Inherited
Integrin beta tail domain0.5005Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5052Inherited
Integrin alpha N-terminal domain0.5305Inherited
C-type lectin-like0.6477Inherited
SMAD/FHA domain0.6601Inherited
Complement control module/SCR domain0.779Inherited
vWA-like0.8291Inherited
L domain-like1Inherited
EGF/Laminin1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Cysteine rich domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Proteasome subunits0Direct
STAT DNA-binding domain0Direct
Transcription factor STAT-4 N-domain0Direct
STAT0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000007596Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0000211Direct
SH2 domain0.00005104Direct
Pyrin domain, PYD0.0000844Direct
SH3-domain0.0001859Direct
Inhibitor of apoptosis (IAP) repeat0.0003727Direct
28-residue LRR0.0008485Direct
Pleckstrin-homology domain (PH domain)0.00125Inherited
Cytochrome p450 reductase N-terminal domain-like0.006316Inherited
C1 set domains (antibody constant domain-like)0.006946Inherited
V set domains (antibody variable domain-like)0.0101Inherited
DBL homology domain (DH-domain)0.01883Inherited
NADPH-cytochrome p450 reductase-like0.01948Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01948Inherited
Caspase recruitment domain, CARD0.02558Inherited
Toll/Interleukin receptor TIR domain0.03531Inherited
MHC antigen-recognition domain0.05083Inherited
TNF receptor-like0.05083Inherited
PLC-like (P variant)0.05799Inherited
Caspase catalytic domain0.0664Inherited
I set domains0.08987Inherited
Interleukin 8-like chemokines0.09338Inherited
DEATH domain, DD0.09338Inherited
ets domain0.09884Inherited
Short-chain cytokines0.1119Inherited
Bcl-2 inhibitors of programmed cell death0.1229Inherited
Rhodopsin-like0.2108Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2328Inherited
Interferon regulatory factor0.294Inherited
Integrin domains0.3001Inherited
WWE domain0.3041Inherited
C-type lectin domain0.3139Inherited
TNF-like0.3352Inherited
Integrin alpha N-terminal domain0.3997Inherited
FHA domain0.4388Inherited
Integrin beta tail domain0.4577Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.4577Inherited
Integrin beta EGF-like domains0.4577Inherited
Interleukin 17F, IL-17F0.5609Inherited
Integrin A (or I) domain0.6826Inherited
Complement control module/SCR domain0.7445Inherited
EGF-type module0.9653Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
Immunoglobulin0.00004301Direct
SH2 domain0.00005018Direct
DEATH domain0.0001592Direct
SH3-domain0.0001856Direct
p53-like transcription factors0.002643Inherited
DBL homology domain (DH-domain)0.01421Inherited
Toll/Interleukin receptor TIR domain0.02696Inherited
TNF receptor-like0.0286Inherited
Caspase-like0.04759Inherited
MHC antigen-recognition domain0.04981Inherited
Flavoproteins0.05934Inherited
L30e-like0.08891Inherited
Interleukin 8-like chemokines0.09215Inherited
Bcl-2 inhibitors of programmed cell death0.1208Inherited
Cysteine-rich domain0.1345Inherited
RNI-like0.1406Inherited
DNA/RNA polymerases0.1637Inherited
Inhibitor of apoptosis (IAP) repeat0.1637Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2218Inherited
4-helical cytokines0.2616Inherited
E set domains0.2742Inherited
Transducin (alpha subunit), insertion domain0.2909Inherited
Integrin domains0.2977Inherited
WWE domain0.3Inherited
TNF-like0.3328Inherited
Family A G protein-coupled receptor-like0.3342Inherited
Integrin beta tail domain0.4529Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4576Inherited
Integrin alpha N-terminal domain0.4834Inherited
C-type lectin-like0.6042Inherited
SMAD/FHA domain0.6174Inherited
Complement control module/SCR domain0.7426Inherited
vWA-like0.7965Inherited
L domain-like0.9899Inherited
EGF/Laminin0.9933Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    57440,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    50370,57440
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000004861Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.000301Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0003416Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.004005Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.005449Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.01614Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.02104Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.02508Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0286Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.03513Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.11Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1208Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.1208Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.1637Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.1637Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.1637Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.2218Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.2218Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2682Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.3Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.3962Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.3962Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.4529Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.4529Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.6361Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    57850,49599,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    50370,57440,56436
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0Direct
    57440,56436,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.005449Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.005449Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.02508Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0296Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.2218Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2218Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.3Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.3Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.3962Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.4529Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.4733Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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