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Mammalian Phenotype (MP): abnormal cell-mediated immunity

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ 1:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
0:   abnormal cell-mediated immunity [MP:0002421] <3>(35|48) (37|33|21)
- 1:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
- 1:   abnormal professional antigen presenting cell physiology [MP:0002452] <3>(25|32) (26|19|12)
- 1:   abnormal type IV hypersensitivity reaction [MP:0002534] <2>(0|1) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Immunoglobulin0.00004215Direct
SH2 domain0.00005828Direct
DEATH domain0.000195Direct
SH3-domain0.0002046Direct
p53-like transcription factors0.003441Inherited
DBL homology domain (DH-domain)0.01916Inherited
Toll/Interleukin receptor TIR domain0.03261Inherited
TNF receptor-like0.03541Inherited
Caspase-like0.05919Inherited
MHC antigen-recognition domain0.0604Inherited
Flavoproteins0.07729Inherited
Interleukin 8-like chemokines0.1059Inherited
L30e-like0.1115Inherited
Bcl-2 inhibitors of programmed cell death0.1423Inherited
Cysteine-rich domain0.1483Inherited
Inhibitor of apoptosis (IAP) repeat0.1894Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2506Inherited
4-helical cytokines0.2747Inherited
E set domains0.2848Inherited
Integrin domains0.3183Inherited
WWE domain0.3325Inherited
TNF-like0.3484Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4621Inherited
Integrin beta tail domain0.483Inherited
Integrin alpha N-terminal domain0.5049Inherited
C-type lectin-like0.5968Inherited
SMAD/FHA domain0.6325Inherited
Family A G protein-coupled receptor-like0.6844Inherited
vWA-like0.8044Inherited
Complement control module/SCR domain0.89Inherited
L domain-like0.9981Inherited
EGF/Laminin1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
STAT DNA-binding domain0Direct
STAT0Direct
Proteasome subunits0Direct
Transcription factor STAT-4 N-domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cysteine rich domain0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000006554Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00001829Direct
SH2 domain0.000028Direct
Pyrin domain, PYD0.00007667Direct
SH3-domain0.0001037Direct
Inhibitor of apoptosis (IAP) repeat0.0003438Direct
28-residue LRR0.0007553Direct
Pleckstrin-homology domain (PH domain)0.0008342Direct
C1 set domains (antibody constant domain-like)0.00573Inherited
Cytochrome p450 reductase N-terminal domain-like0.006017Inherited
V set domains (antibody variable domain-like)0.007584Inherited
DBL homology domain (DH-domain)0.01665Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01861Inherited
NADPH-cytochrome p450 reductase-like0.01861Inherited
Caspase recruitment domain, CARD0.0224Inherited
Toll/Interleukin receptor TIR domain0.02952Inherited
MHC antigen-recognition domain0.04413Inherited
TNF receptor-like0.04413Inherited
PLC-like (P variant)0.04991Inherited
Caspase catalytic domain0.06008Inherited
Interleukin 8-like chemokines0.08188Inherited
DEATH domain, DD0.08188Inherited
I set domains0.08671Inherited
ets domain0.09297Inherited
Short-chain cytokines0.101Inherited
Bcl-2 inhibitors of programmed cell death0.1141Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.2172Inherited
C-type lectin domain0.2726Inherited
Integrin domains0.276Inherited
Interferon regulatory factor0.2765Inherited
WWE domain0.2913Inherited
TNF-like0.305Inherited
Integrin alpha N-terminal domain0.3768Inherited
FHA domain0.4271Inherited
Integrin beta EGF-like domains0.4392Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.4392Inherited
Integrin beta tail domain0.4392Inherited
Rhodopsin-like0.4479Inherited
Interleukin 17F, IL-17F0.5436Inherited
Integrin A (or I) domain0.6556Inherited
Complement control module/SCR domain0.8665Inherited
EGF-type module0.9533Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
Immunoglobulin0.00001962Direct
SH2 domain0.00002748Direct
DEATH domain0.00009835Direct
SH3-domain0.0001035Direct
p53-like transcription factors0.002011Inherited
DBL homology domain (DH-domain)0.01252Inherited
Toll/Interleukin receptor TIR domain0.02231Inherited
TNF receptor-like0.02436Inherited
Caspase-like0.04253Inherited
MHC antigen-recognition domain0.04351Inherited
Flavoproteins0.05688Inherited
Interleukin 8-like chemokines0.08052Inherited
L30e-like0.0854Inherited
Bcl-2 inhibitors of programmed cell death0.1119Inherited
Cysteine-rich domain0.1171Inherited
RNI-like0.1244Inherited
Inhibitor of apoptosis (IAP) repeat0.1537Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.2103Inherited
4-helical cytokines0.2329Inherited
E set domains0.2424Inherited
Integrin domains0.2742Inherited
WWE domain0.2878Inherited
TNF-like0.3031Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.4144Inherited
Integrin beta tail domain0.4353Inherited
Integrin alpha N-terminal domain0.4573Inherited
C-type lectin-like0.5513Inherited
SMAD/FHA domain0.5881Inherited
Family A G protein-coupled receptor-like0.6427Inherited
vWA-like0.7699Inherited
Transducin (alpha subunit), insertion domain0.7765Inherited
Complement control module/SCR domain0.8623Inherited
L domain-like0.9846Inherited
EGF/Laminin0.9887Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    50370,57440
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    48366,47473
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 0Direct
    57440,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000004195Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0002774Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0003128Direct
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.002454Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.005182Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.01332Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.01878Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.02185Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.02436Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.03366Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.09919Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.1119Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.1537Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.1537Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.1537Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.2103Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.2103Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2325Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.2878Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.3739Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.3739Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.4353Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.4353Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.6314Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.8117Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57850,49599,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    57440,56436,56436
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    48366,47473,57889
  • 48366 - Ras GEF
  • 47473 - EF-hand
  • 57889 - Cysteine-rich domain
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    50370,57440,56436
  • 50370 - Ricin B-like lectins
  • 57440 - Kringle-like
  • 56436 - C-type lectin-like
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.005182Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.005182Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.02185Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.02774Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2103Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.2103Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.2878Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.2878Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.3739Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.4353Inherited
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.4503Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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