SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Mammalian Phenotype (MP): abnormal T cell physiology

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   mammalian phenotype [MP:0000001] <29>
+ + + + + 5:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + + 5:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + 4:   abnormal hematopoietic system physiology [MP:0001545] <5>(39|53) (40|38|21)
+ + + + 4:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + + 3:   abnormal adaptive immunity [MP:0002420] <8>(36|48) (38|33|21)
+ + + 3:   abnormal immune cell physiology [MP:0001819] <3>(35|48) (37|33|21)
+ + + 3:   abnormal blood cell physiology [MP:0012382] <3>(38|53) (39|38|21)
+ + + 3:   abnormal cell-mediated immunity [MP:0002421] <3>(35|48) (37|33|21)
+ + 2:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
+ 1:   abnormal lymphocyte physiology [MP:0003945] <4>(21|31) (23|22|13)
0:   abnormal T cell physiology [MP:0002444] <7>(8|15) (11|16|7)
- 1:   abnormal CD4-positive, alpha-beta T cell physiology [MP:0005463] <4>(0|0) (0|0|0)
- 1:   abnormal T cell apoptosis [MP:0006412] <4>(2|3) (2|1|0)
- 1:   abnormal T cell activation [MP:0001828] <2>(3|7) (5|14|7)
- 1:   abnormal regulatory T cell physiology [MP:0004946] <2>(0|0) (0|0|0)
- 1:   abnormal CD8-positive, alpha-beta T cell physiology [MP:0004392] <1>(3|4) (4|1|0)
- 1:   abnormal memory T cell physiology [MP:0008051] <1>(0|0) (0|0|0)
- 1:   abnormal NK T cell physiology [MP:0008042](1|1) (1|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Caspase-like0.00000003572Direct
Bcl-2 inhibitors of programmed cell death0.0003998Direct
STAT0.1458Inherited
Transcription factor STAT-4 N-domain0.1458Inherited
Toll/Interleukin receptor TIR domain0.6522Inherited
TNF receptor-like0.7044Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.8138Inherited
MHC antigen-recognition domain0.8226Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Rel/Dorsal transcription factors, DNA-binding domain0.0000000004419Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.000000009831Direct
Caspase catalytic domain0.0000002159Direct
Caspase recruitment domain, CARD0.000001655Direct
Bcl-2 inhibitors of programmed cell death0.0002639Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0.0007179Direct
STAT DNA-binding domain0.1184Inherited
STAT0.1184Inherited
Transcription factor STAT-4 N-domain0.1184Inherited
C1 set domains (antibody constant domain-like)0.5438Inherited
V set domains (antibody variable domain-like)0.5817Inherited
TNF receptor-like0.6148Inherited
Toll/Interleukin receptor TIR domain0.6856Inherited
PLC-like (P variant)0.7322Inherited
MHC antigen-recognition domain0.7941Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Caspase-like0.00000001375Direct
Bcl-2 inhibitors of programmed cell death0.0002085Direct
p53-like transcription factors0.005768Inherited
Transducin (alpha subunit), insertion domain0.02048Inherited
STAT0.115Inherited
Transcription factor STAT-4 N-domain0.115Inherited
DBL homology domain (DH-domain)0.1335Inherited
Toll/Interleukin receptor TIR domain0.609Inherited
TNF receptor-like0.6636Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.7798Inherited
MHC antigen-recognition domain0.7894Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000000002545Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.000004696Direct
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.001251Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01573Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.115Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.115Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.115Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.1574Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.2922Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.467Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.5413Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5413Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.5461Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.7233Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.818Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.001251Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.115Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.115Inherited
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.2922Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5446Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)