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Mammalian Phenotype (MP): abnormal professional antigen presenting cell physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + 2:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ 1:   abnormal immune cell physiology [MP:0001819] <3>(35|48) (37|33|21)
+ 1:   abnormal cell-mediated immunity [MP:0002421] <3>(35|48) (37|33|21)
+ 1:   abnormal adaptive immunity [MP:0002420] <8>(36|48) (38|33|21)
0:   abnormal professional antigen presenting cell physiology [MP:0002452] <3>(25|32) (26|19|12)
- 1:   abnormal macrophage physiology [MP:0002451] <10>(7|6) (8|4|2)
- 1:   abnormal B cell physiology [MP:0002459] <9>(19|27) (20|16|10)
- 1:   abnormal dendritic cell physiology [MP:0002376] <5>(2|2) (2|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
DEATH domain0.01516Inherited
WWE domain0.02898Inherited
Flavoproteins0.02898Inherited
4-helical cytokines0.02977Inherited
Toll/Interleukin receptor TIR domain0.02977Inherited
L30e-like0.04409Inherited
E set domains0.1406Inherited
TNF receptor-like0.2002Inherited
TNF-like0.2002Inherited
Bcl-2 inhibitors of programmed cell death0.2146Inherited
SMAD/FHA domain0.2388Inherited
SH2 domain0.245Inherited
L domain-like0.2853Inherited
EGF/Laminin0.3606Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3614Inherited
p53-like transcription factors0.4805Inherited
Caspase-like0.5467Inherited
DBL homology domain (DH-domain)0.5706Inherited
Inhibitor of apoptosis (IAP) repeat0.6231Inherited
MHC antigen-recognition domain0.698Inherited
STAT0.7132Inherited
Transcription factor STAT-4 N-domain0.7132Inherited
Family A G protein-coupled receptor-like0.7506Inherited
SH3-domain0.8118Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Short-chain cytokines0.0000001168Direct
Cytochrome p450 reductase N-terminal domain-like0.001762Inherited
NADPH-cytochrome p450 reductase-like0.005943Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.005943Inherited
Interleukin 17F, IL-17F0.005943Inherited
WWE domain0.01292Inherited
ets domain0.01762Inherited
Toll/Interleukin receptor TIR domain0.03061Inherited
I set domains0.03974Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.05995Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.08021Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1418Inherited
TNF-like0.1786Inherited
C1 set domains (antibody constant domain-like)0.1786Inherited
Bcl-2 inhibitors of programmed cell death0.1881Inherited
FHA domain0.1909Inherited
DEATH domain, DD0.2173Inherited
SH2 domain0.234Inherited
TNF receptor-like0.2621Inherited
PLC-like (P variant)0.2983Inherited
V set domains (antibody variable domain-like)0.3041Inherited
Proteasome subunits0.3301Inherited
DBL homology domain (DH-domain)0.5488Inherited
Inhibitor of apoptosis (IAP) repeat0.5954Inherited
Caspase catalytic domain0.6036Inherited
Pleckstrin-homology domain (PH domain)0.6307Inherited
MHC antigen-recognition domain0.6782Inherited
STAT DNA-binding domain0.6907Inherited
Transcription factor STAT-4 N-domain0.6907Inherited
STAT0.6907Inherited
SH3-domain0.8093Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
DEATH domain0.009741Inherited
WWE domain0.01963Inherited
Flavoproteins0.01963Inherited
Toll/Interleukin receptor TIR domain0.02023Inherited
4-helical cytokines0.02023Inherited
L30e-like0.03084Inherited
RNI-like0.05855Inherited
E set domains0.1104Inherited
TNF receptor-like0.1634Inherited
TNF-like0.1634Inherited
Bcl-2 inhibitors of programmed cell death0.1768Inherited
SMAD/FHA domain0.1993Inherited
SH2 domain0.2051Inherited
L domain-like0.2428Inherited
EGF/Laminin0.3148Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.3157Inherited
p53-like transcription factors0.4328Inherited
Caspase-like0.4999Inherited
DBL homology domain (DH-domain)0.5243Inherited
Inhibitor of apoptosis (IAP) repeat0.5782Inherited
MHC antigen-recognition domain0.657Inherited
STAT0.6732Inherited
Transcription factor STAT-4 N-domain0.6732Inherited
Family A G protein-coupled receptor-like0.7124Inherited
SH3-domain0.7777Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.001458Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.00497Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.005136Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.01097Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.02436Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.05855Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.07302Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1071Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1993Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.2359Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.2359Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.2359Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.3546Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.3838Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.4757Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.6732Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.6732Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.6732Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    57850,49599,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 49599 - TRAF domain-like
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.001458Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.001458Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.00497Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.00497Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.1577Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1768Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.3157Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.6732Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.6732Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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