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Mammalian Phenotype (MP): abnormal B cell physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + 4:   abnormal hematopoietic system physiology [MP:0001545] <5>(39|53) (40|38|21)
+ + + 3:   abnormal blood cell physiology [MP:0012382] <3>(38|53) (39|38|21)
+ + + 3:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + 2:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
+ + 2:   abnormal adaptive immunity [MP:0002420] <8>(36|48) (38|33|21)
+ + 2:   abnormal immune cell physiology [MP:0001819] <3>(35|48) (37|33|21)
+ + 2:   abnormal cell-mediated immunity [MP:0002421] <3>(35|48) (37|33|21)
+ 1:   abnormal lymphocyte physiology [MP:0003945] <4>(21|31) (23|22|13)
+ 1:   abnormal professional antigen presenting cell physiology [MP:0002452] <3>(25|32) (26|19|12)
0:   abnormal B cell physiology [MP:0002459] <9>(19|27) (20|16|10)
- 1:   abnormal immunoglobulin level [MP:0002490] <7>(8|12) (9|9|7)
- 1:   abnormal B cell apoptosis [MP:0008781] <3>(2|3) (2|1|1)
- 1:   abnormal B cell activation [MP:0008217] <1>(7|11) (7|6|1)
- 1:   abnormal B lymphocyte antigen presentation [MP:0002453] <1>(7|7) (7|4|2)
- 1:   abnormal class switch recombination [MP:0004816](1|1) (1|0|0)
- 1:   abnormal follicular B cell physiology [MP:0008191](0|0) (0|0|0)
- 1:   abnormal germinal center B cell physiology [MP:0008192](0|0) (0|0|0)
- 1:   abnormal marginal zone B cell physiology [MP:0008193](0|0) (0|0|0)
- 1:   abnormal memory B cell physiology [MP:0008194](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Bcl-2 inhibitors of programmed cell death0.0003375Direct
WWE domain0.009711Inherited
L30e-like0.01536Inherited
TNF receptor-like0.02546Inherited
TNF-like0.03797Inherited
SMAD/FHA domain0.05401Inherited
p53-like transcription factors0.09874Inherited
E set domains0.1285Inherited
4-helical cytokines0.1466Inherited
Toll/Interleukin receptor TIR domain0.1466Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.1739Inherited
SH2 domain0.2433Inherited
Inhibitor of apoptosis (IAP) repeat0.3512Inherited
Family A G protein-coupled receptor-like0.3612Inherited
SH3-domain0.4109Inherited
MHC antigen-recognition domain0.4655Inherited
DBL homology domain (DH-domain)0.4655Inherited
STAT0.6582Inherited
Transcription factor STAT-4 N-domain0.6582Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Bcl-2 inhibitors of programmed cell death0.000228Direct
Interleukin 17F, IL-17F0.001668Inherited
WWE domain0.003871Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.006762Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.01154Inherited
TNF-like0.02869Inherited
ets domain0.03246Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.03246Inherited
Short-chain cytokines0.04153Inherited
TNF receptor-like0.04322Inherited
FHA domain0.06654Inherited
V set domains (antibody variable domain-like)0.08139Inherited
Pleckstrin-homology domain (PH domain)0.1201Inherited
PLC-like (P variant)0.1431Inherited
Proteasome subunits0.146Inherited
Toll/Interleukin receptor TIR domain0.1644Inherited
DEATH domain, DD0.1914Inherited
I set domains0.2099Inherited
SH2 domain0.2206Inherited
C1 set domains (antibody constant domain-like)0.2749Inherited
Inhibitor of apoptosis (IAP) repeat0.3166Inherited
SH3-domain0.3868Inherited
MHC antigen-recognition domain0.4328Inherited
DBL homology domain (DH-domain)0.4328Inherited
STAT DNA-binding domain0.6281Inherited
Transcription factor STAT-4 N-domain0.6281Inherited
STAT0.6281Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Bcl-2 inhibitors of programmed cell death0.0001754Direct
WWE domain0.006054Inherited
L30e-like0.009889Inherited
TNF receptor-like0.01704Inherited
TNF-like0.02624Inherited
SMAD/FHA domain0.03841Inherited
p53-like transcription factors0.07444Inherited
E set domains0.0998Inherited
Toll/Interleukin receptor TIR domain0.1156Inherited
4-helical cytokines0.1156Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.1396Inherited
SH2 domain0.2035Inherited
Inhibitor of apoptosis (IAP) repeat0.3058Inherited
Family A G protein-coupled receptor-like0.3155Inherited
DEATH domain0.337Inherited
SH3-domain0.3642Inherited
DBL homology domain (DH-domain)0.4178Inherited
MHC antigen-recognition domain0.4178Inherited
STAT0.6152Inherited
Transcription factor STAT-4 N-domain0.6152Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.001383Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.003235Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.00494Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.01042Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.03841Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.07944Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0845Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0845Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.2027Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.2085Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.2138Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.3132Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.6152Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.6152Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.6152Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.0003856Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0003856Direct
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.001383Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.003727Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.1271Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1396Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.6152Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.6152Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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