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Mammalian Phenotype (MP): abnormal blood coagulation

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + + 3:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ + 2:   abnormal blood homeostasis [MP:0009642] <23>(63|82) (70|45|21)
+ 1:   abnormal hemostasis [MP:0009676] <1>(13|16) (15|12|5)
0:   abnormal blood coagulation [MP:0002551] <8>(13|16) (15|12|5)
- 1:   abnormal thrombosis [MP:0005048] <5>(4|4) (4|0|1)
- 1:   abnormal partial thromboplastin time [MP:0012357] <2>(0|0) (0|0|0)
- 1:   abnormal platelet physiology [MP:0005464] <2>(5|8) (6|5|1)
- 1:   abnormal prothrombin time [MP:0012354] <2>(0|0) (0|0|0)
- 1:   decreased bleeding time [MP:0005607] <2>(0|0) (0|0|0)
- 1:   increased bleeding time [MP:0005606] <2>(0|0) (0|0|0)
- 1:   abnormal thrombolysis [MP:0003422] <1>(0|0) (0|0|0)
- 1:   impaired blood coagulation [MP:0020215](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
GLA-domain0.00000000044Direct
EGF/Laminin0.000000301Direct
Trypsin-like serine proteases0.00004059Direct
Flavoproteins0.00068Direct
Kringle-like0.0009181Direct
Transducin (alpha subunit), insertion domain0.001276Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.003641Inherited
Riboflavin synthase domain-like0.003641Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.004986Inherited
PLC-like phosphodiesterases0.007958Inherited
Integrin domains0.009529Inherited
PH domain-like0.1398Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
GLA-domain0.0000000003226Direct
EGF-type module0.0000001188Direct
Eukaryotic proteases0.00001574Direct
Phoshoinositide 3-kinase (PI3K) helical domain0.00001578Direct
Cytochrome p450 reductase N-terminal domain-like0.00002302Direct
PLC-like (P variant)0.00002838Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.00009202Direct
NADPH-cytochrome p450 reductase-like0.00009202Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0004826Direct
Kringle modules0.0006761Direct
Transducin (alpha subunit), insertion domain0.0009252Direct
Mammalian PLC0.003635Inherited
Integrin domains0.007543Inherited
G proteins0.04308Inherited
Pleckstrin-homology domain (PH domain)0.05309Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
GLA-domain0.0000000001618Direct
EGF/Laminin0.0000001206Direct
Trypsin-like serine proteases0.00001887Direct
Flavoproteins0.0003634Direct
Kringle-like0.000499Direct
Transducin (alpha subunit), insertion domain0.000708Direct
FnI-like domain0.0009551Direct
Riboflavin synthase domain-like0.002135Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.002135Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.002986Inherited
PLC-like phosphodiesterases0.004894Inherited
Integrin domains0.005934Inherited
SH2 domain0.09129Inherited
PH domain-like0.1097Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,50494
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.00001105Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.00002644Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00002644Direct
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.00005307Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00009263Direct
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0005164Direct
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.0006314Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0009551Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.002135Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.002135Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.00001105Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.00007022Direct
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.000168Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0003656Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.002135Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)