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Mammalian Phenotype (MP): abnormal lymphocyte morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   mammalian phenotype [MP:0000001] <29>
+ + + + + 5:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + + 5:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + 4:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(58|86) (66|47|21)
+ + + + 4:   abnormal immune system morphology [MP:0000685] <3>(51|76) (60|35|18)
+ + + 3:   abnormal immune system cell morphology [MP:0000716] <5>(38|63) (48|29|16)
+ + + 3:   abnormal hematopoietic cell morphology [MP:0013656] <9>(49|77) (60|43|18)
+ + 2:   abnormal leukocyte morphology [MP:0008246] <4>(37|62) (47|29|15)
+ 1:   abnormal mononuclear cell morphology [MP:0008247] <2>(34|57) (41|28|14)
0:   abnormal lymphocyte morphology [MP:0002619] <5>(28|46) (33|26|14)
- 1:   abnormal T cell morphology [MP:0008037] <9>(14|25) (18|19|11)
- 1:   abnormal B cell morphology [MP:0004939] <6>(18|28) (20|11|6)
- 1:   abnormal lymphocyte cell number [MP:0000717] <6>(18|38) (25|21|9)
- 1:   abnormal NK cell morphology [MP:0005068] <5>(0|0) (0|0|0)
- 1:   abnormal lymphopoiesis [MP:0002401] <3>(19|25) (21|15|6)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
PsbU/PolX domain-like0Direct
p53-like transcription factors0.0000009579Direct
BRCT domain0.0009633Direct
DNA polymerase beta, N-terminal domain-like0.00156Inherited
Bcl-2 inhibitors of programmed cell death0.008088Inherited
Toll/Interleukin receptor TIR domain0.01208Inherited
Ran binding protein zinc finger-like0.01225Inherited
E2F-DP heterodimerization region0.01291Inherited
SH2 domain0.01523Inherited
DEATH domain0.01972Inherited
Integrin alpha N-terminal domain0.03308Inherited
WWE domain0.0636Inherited
DNA/RNA polymerases0.1016Inherited
TNF receptor-like0.1174Inherited
SH3-domain0.1332Inherited
Cysteine-rich domain0.1337Inherited
Immunoglobulin0.1364Inherited
Nucleotidyltransferase0.1562Inherited
SMAD/FHA domain0.2533Inherited
MHC antigen-recognition domain0.2533Inherited
DBL homology domain (DH-domain)0.2533Inherited
SET domain0.2869Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.4788Inherited
Integrin domains0.5564Inherited
Calponin-homology domain, CH-domain0.6572Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Proteasome subunits0Direct
STAT DNA-binding domain0Direct
RUNT domain0Direct
DNA polymerase beta-like0Direct
BAFF receptor-like0Direct
Transcription factor STAT-4 N-domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
STAT0Direct
Interleukin 17F, IL-17F0Direct
DNA polymerase beta-like, second domain0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000121Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00009219Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0003334Direct
Pointed domain0.001021Inherited
DNA polymerase beta, N-terminal domain-like0.001051Inherited
E2F dimerization segment0.004033Inherited
Bcl-2 inhibitors of programmed cell death0.006012Inherited
Interferon regulatory factor0.006012Inherited
Ran binding protein zinc finger-like0.009563Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.009666Inherited
PLC-like (P variant)0.01117Inherited
SH2 domain0.01443Inherited
Nuclear receptor coactivator interlocking domain0.01464Inherited
Toll/Interleukin receptor TIR domain0.02112Inherited
Cell cycle transcription factor e2f-dp0.03023Inherited
WWE domain0.03024Inherited
DNA polymerase I0.03024Inherited
V set domains (antibody variable domain-like)0.03473Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.05153Inherited
MATH domain0.06456Inherited
CCCH zinc finger0.08652Inherited
Pleckstrin-homology domain (PH domain)0.1047Inherited
SH3-domain0.1296Inherited
C1 set domains (antibody constant domain-like)0.1376Inherited
TNF receptor-like0.1575Inherited
DEATH domain, DD0.1575Inherited
Caspase recruitment domain, CARD0.1978Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2059Inherited
FHA domain0.2077Inherited
MHC antigen-recognition domain0.2345Inherited
ets domain0.2345Inherited
DBL homology domain (DH-domain)0.2345Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.3065Inherited
Myb/SANT domain0.3998Inherited
Integrin domains0.5417Inherited
Calponin-homology domain, CH-domain0.6429Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
p53-like transcription factors0.0000003902Direct
BRCT domain0.0005247Direct
DNA polymerase beta, N-terminal domain-like0.0008744Direct
Bcl-2 inhibitors of programmed cell death0.004979Inherited
Toll/Interleukin receptor TIR domain0.007646Inherited
Ran binding protein zinc finger-like0.007763Inherited
E2F-DP heterodimerization region0.008207Inherited
SH2 domain0.009791Inherited
Nuclear receptor coactivator interlocking domain0.01273Inherited
DEATH domain0.01291Inherited
Integrin alpha N-terminal domain0.02264Inherited
WWE domain0.04609Inherited
CCCH zinc finger0.07688Inherited
DNA/RNA polymerases0.07688Inherited
TNF receptor-like0.09044Inherited
SH3-domain0.104Inherited
Cysteine-rich domain0.1045Inherited
Immunoglobulin0.1068Inherited
Nucleotidyltransferase0.1242Inherited
SMAD/FHA domain0.2128Inherited
DBL homology domain (DH-domain)0.2128Inherited
MHC antigen-recognition domain0.2128Inherited
SET domain0.2445Inherited
beta-beta-alpha zinc fingers0.2487Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.4312Inherited
Acyl-CoA N-acyltransferases (Nat)0.4722Inherited
Integrin domains0.5098Inherited
Protein kinase-like (PK-like)0.5387Inherited
Calponin-homology domain, CH-domain0.6141Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.000008429Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.0001818Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.0001818Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0001932Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0006103Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.003999Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.008207Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.008207Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.01595Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.01595Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.02644Inherited
    57850,49599
  • 57850 - RING/U-box
  • 49599 - TRAF domain-like
  • 0.06972Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.06972Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.07515Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.2128Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.2128Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.2128Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.4358Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.473Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.003999Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.008207Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.01595Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.06972Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.3251Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.6808Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)