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Mammalian Phenotype (MP): abnormal immune system organ morphology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ 1:   abnormal immune system morphology [MP:0000685] <3>(51|76) (60|35|18)
0:   abnormal immune system organ morphology [MP:0002722] <8>(21|31) (26|15|9)
- 1:   abnormal spleen morphology [MP:0000689] <16>(10|15) (12|8|8)
- 1:   abnormal thymus morphology [MP:0000703] <14>(10|16) (12|10|2)
- 1:   abnormal lymph node morphology [MP:0002339] <11>(10|10) (12|4|1)
- 1:   abnormal lymph organ size [MP:0002221] <5>(7|16) (10|10|5)
- 1:   abnormal gut-associated lymphoid tissue morphology [MP:0002378] <1>(6|7) (6|2|0)
- 1:   abnormal lymph organ development [MP:0002450] <1>(0|0) (0|0|0)
- 1:   abnormal mucosa-associated lymphoid tissue morphology [MP:0002377] <1>(0|0) (0|0|0)
- 1:   abnormal bronchus-associated lymphoid tissue morphology [MP:0002393](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
SH2 domain0.0006336Direct
Bcl-2 inhibitors of programmed cell death0.0008514Direct
DEATH domain0.009983Inherited
TNF-like0.01568Inherited
Complement control module/SCR domain0.01877Inherited
p53-like transcription factors0.01999Inherited
E set domains0.04015Inherited
WWE domain0.05619Inherited
Nuclear receptor ligand-binding domain0.06525Inherited
TNF receptor-like0.08282Inherited
Caspase-like0.08873Inherited
CCCH zinc finger0.1054Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1295Inherited
Cysteine-rich domain0.2094Inherited
Inhibitor of apoptosis (IAP) repeat0.2264Inherited
Notch domain0.2264Inherited
Integrin domains0.3371Inherited
Ankyrin repeat0.4101Inherited
Homeodomain-like0.4514Inherited
4-helical cytokines0.634Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
RUNT domain0Direct
SH2 domain0.0005154Direct
Bcl-2 inhibitors of programmed cell death0.0005761Direct
Interferon regulatory factor0.004799Inherited
TNF-like0.012Inherited
DEATH domain, DD0.012Inherited
Nuclear receptor coactivator interlocking domain0.01261Inherited
Complement control module/SCR domain0.01557Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.01561Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.02415Inherited
Linker histone H1/H50.02549Inherited
WWE domain0.02622Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.04496Inherited
Nuclear receptor ligand-binding domain0.05513Inherited
Nuclear receptor0.05513Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.05514Inherited
Pyrin domain, PYD0.05716Inherited
TNF receptor-like0.06477Inherited
CCCH zinc finger0.08724Inherited
ets domain0.08923Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.1203Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.1235Inherited
Notch domain0.1989Inherited
Inhibitor of apoptosis (IAP) repeat0.1989Inherited
E2F dimerization segment0.1989Inherited
Integrin domains0.3133Inherited
Ankyrin repeat0.397Inherited
Pointed domain0.4064Inherited
Interleukin 17F, IL-17F0.4064Inherited
Homeodomain0.8381Inherited
C-type lectin domain0.9875Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SPOC domain-like0Direct
SH2 domain0.000338Direct
Bcl-2 inhibitors of programmed cell death0.0004611Direct
DEATH domain0.006234Inherited
TNF-like0.0101Inherited
Nuclear receptor coactivator interlocking domain0.011Inherited
Complement control module/SCR domain0.01224Inherited
p53-like transcription factors0.0131Inherited
E set domains0.02789Inherited
Protein kinase-like (PK-like)0.03773Inherited
WWE domain0.04016Inherited
Nuclear receptor ligand-binding domain0.04739Inherited
TNF receptor-like0.06132Inherited
Caspase-like0.06627Inherited
CCCH zinc finger0.08007Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1007Inherited
Cysteine-rich domain0.1718Inherited
Notch domain0.1878Inherited
Inhibitor of apoptosis (IAP) repeat0.1878Inherited
Integrin domains0.292Inherited
Ankyrin repeat0.3634Inherited
Homeodomain-like0.4037Inherited
beta-beta-alpha zinc fingers0.4352Inherited
4-helical cytokines0.5897Inherited
vWA-like0.6056Inherited
C-type lectin-like0.9843Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.000144Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.003416Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.02139Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.02819Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.03233Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.05195Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.06273Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1058Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.1231Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1501Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.1878Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.3219Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01285Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.05195Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.05726Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1458Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.1878Inherited
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.1878Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.1878Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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