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Mammalian Phenotype (MP): abnormal immune serum protein physiology

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ 1:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
0:   abnormal immune serum protein physiology [MP:0002723] <4>(25|40) (31|24|12)
- 1:   abnormal immunoglobulin level [MP:0002490] <7>(8|12) (9|9|7)
- 1:   abnormal cytokine level [MP:0008713] <5>(11|18) (11|7|2)
- 1:   abnormal cytokine secretion [MP:0003009] <4>(17|33) (23|19|8)
- 1:   abnormal acute phase protein level [MP:0010211] <3>(1|1) (1|1|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
SH2 domain0.000001975Direct
DEATH domain0.000004466Direct
Toll/Interleukin receptor TIR domain0.000005584Direct
RNI-like0.0005053Direct
TNF receptor-like0.001475Inherited
4-helical cytokines0.002273Inherited
Triple coiled coil domain of C-type lectins0.003536Inherited
p53-like transcription factors0.003544Inherited
Fibronectin type III0.02518Inherited
STAT0.0369Inherited
Transcription factor STAT-4 N-domain0.0369Inherited
TNF-like0.04785Inherited
L30e-like0.05731Inherited
SH3-domain0.0713Inherited
CCCH zinc finger0.1597Inherited
DBL homology domain (DH-domain)0.2091Inherited
SMAD/FHA domain0.2091Inherited
Transducin (alpha subunit), insertion domain0.2699Inherited
Bcl-2 inhibitors of programmed cell death0.3673Inherited
Family A G protein-coupled receptor-like0.371Inherited
MHC antigen-recognition domain0.4341Inherited
Caspase-like0.5123Inherited
Kringle-like0.8063Inherited
L domain-like0.8709Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Interleukin 17F, IL-17F0Direct
Interferon regulatory factor0.0000003183Direct
SH2 domain0.000001088Direct
Toll/Interleukin receptor TIR domain0.000005741Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0.00001352Direct
Pyrin domain, PYD0.00001352Direct
28-residue LRR0.00008857Direct
PLC-like (P variant)0.002023Inherited
Triple coiled coil domain of C-type lectins0.002448Inherited
TNF receptor-like0.002705Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.005062Inherited
Notch domain0.008114Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.008975Inherited
V set domains (antibody variable domain-like)0.01015Inherited
Short-chain cytokines0.01267Inherited
Caspase recruitment domain, CARD0.01267Inherited
EF-hand modules in multidomain proteins0.01558Inherited
Fibronectin type III0.01864Inherited
DEATH domain, DD0.0209Inherited
STAT DNA-binding domain0.02684Inherited
Interferons/interleukin-10 (IL-10)0.02684Inherited
STAT0.02684Inherited
Transcription factor STAT-4 N-domain0.02684Inherited
TNF-like0.03593Inherited
SH3-domain0.05649Inherited
Interleukin-1 (IL-1)0.07838Inherited
Cell cycle control phosphatase, catalytic domain0.1139Inherited
Long-chain cytokines0.1282Inherited
CCCH zinc finger0.1407Inherited
Pleckstrin-homology domain (PH domain)0.1691Inherited
DBL homology domain (DH-domain)0.1785Inherited
Transducin (alpha subunit), insertion domain0.2353Inherited
C1 set domains (antibody constant domain-like)0.3183Inherited
Bcl-2 inhibitors of programmed cell death0.33Inherited
MHC antigen-recognition domain0.3972Inherited
RING finger domain, C3HC40.4226Inherited
I set domains0.4413Inherited
Kringle modules0.451Inherited
Caspase catalytic domain0.5894Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
SH2 domain0.0000008162Direct
DEATH domain0.000001904Direct
Toll/Interleukin receptor TIR domain0.000002399Direct
RNI-like0.0002673Direct
TNF receptor-like0.0008263Direct
4-helical cytokines0.001298Inherited
Triple coiled coil domain of C-type lectins0.002071Inherited
p53-like transcription factors0.002076Inherited
Notch domain0.006907Inherited
Fibronectin type III0.01684Inherited
STAT0.02544Inherited
Transcription factor STAT-4 N-domain0.02544Inherited
TNF-like0.03368Inherited
L30e-like0.04104Inherited
Rhodanese/Cell cycle control phosphatase0.04833Inherited
SH3-domain0.05223Inherited
RING/U-box0.09557Inherited
CCCH zinc finger0.1273Inherited
SMAD/FHA domain0.1716Inherited
DBL homology domain (DH-domain)0.1716Inherited
Transducin (alpha subunit), insertion domain0.2284Inherited
Bcl-2 inhibitors of programmed cell death0.3214Inherited
Family A G protein-coupled receptor-like0.3251Inherited
"Winged helix" DNA-binding domain0.3402Inherited
MHC antigen-recognition domain0.3869Inherited
Caspase-like0.4649Inherited
PH domain-like0.5095Inherited
Kringle-like0.7719Inherited
L domain-like0.8415Inherited
Cystine-knot cytokines0.8454Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.00005678Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.001438Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.002071Inherited
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.003805Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.005551Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.008299Inherited
    52821,52799
  • 52821 - Rhodanese/Cell cycle control phosphatase
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.01304Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.01491Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02544Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.02544Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02544Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.0265Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0559Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.07503Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.1234Inherited
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.1273Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.1885Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.2269Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.2784Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3214Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.4413Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.4649Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.002071Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.002071Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02544Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02544Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.04407Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.04845Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.07503Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.07503Inherited
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.1273Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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