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Mammalian Phenotype (MP): abnormal cardiovascular development

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   cardiovascular system phenotype [MP:0005385] <2>(67|85) (77|57|35)
+ 1:   abnormal cardiovascular system morphology [MP:0002127] <7>(48|65) (53|44|33)
0:   abnormal cardiovascular development [MP:0002925] <10>(16|35) (25|19|9)
- 1:   abnormal heart development [MP:0000267] <10>(5|11) (6|6|4)
- 1:   abnormal vascular development [MP:0000259] <9>(13|24) (18|13|5)
- 1:   abnormal cardiac neural crest cell morphology [MP:0012747] <3>(0|0) (0|0|0)
- 1:   abnormal cardiac outflow tract development [MP:0006126] <3>(0|3) (1|1|0)
- 1:   abnormal aortic sac morphology [MP:0012510] <1>(0|0) (0|0|0)
- 1:   abnormal cardiogenic plate morphology [MP:0012498] <1>(0|0) (0|0|0)
- 1:   abnormal angioblastic cord morphology [MP:0012500](0|0) (0|0|0)
- 1:   abnormal cardiac epithelial to mesenchymal transition [MP:0008825](1|2) (2|1|0)
- 1:   abnormal cardiac mesenchyme morphology [MP:0011264](0|0) (0|0|0)
- 1:   abnormal cardiogenic mesoderm morphology [MP:0012278](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SMAD MH1 domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
"Winged helix" DNA-binding domain0.000002635Direct
Notch domain0.0001614Direct
p53-like transcription factors0.001238Inherited
EGF/Laminin0.007104Inherited
Orange domain-like0.01486Inherited
Growth factor receptor domain0.05475Inherited
FnI-like domain0.1834Inherited
Hemopexin-like domain0.2428Inherited
PYP-like sensor domain (PAS domain)0.2496Inherited
SH3-domain0.3386Inherited
Frizzled cysteine-rich domain0.3448Inherited
PGBD-like0.3519Inherited
Nuclear receptor ligand-binding domain0.6174Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.6729Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
SMAD MH1 domain0Direct
Retinoblastoma tumor suppressor domains0Direct
SMAD domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
DIX domain0.00001302Direct
Pointed domain0.00006746Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0001056Direct
Notch domain0.0001056Direct
NADPH-cytochrome p450 reductase-like0.0001056Direct
Erythroid transcription factor GATA-10.000208Direct
ets domain0.001195Inherited
T-box0.001415Inherited
Hairy Orange domain0.01137Inherited
EGF-type module0.01219Inherited
HLH, helix-loop-helix DNA-binding domain0.01941Inherited
Integrin beta EGF-like domains0.02269Inherited
Transforming growth factor (TGF)-beta0.0238Inherited
Linker histone H1/H50.02673Inherited
DBL homology domain (DH-domain)0.07099Inherited
Fibronectin type III0.07527Inherited
DEP domain0.08366Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.1189Inherited
Growth factor receptor domain0.1471Inherited
ZZ domain0.198Inherited
Hemopexin-like domain0.215Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.215Inherited
HMG-box0.3Inherited
Frizzled cysteine-rich domain0.3157Inherited
MMP N-terminal domain0.3223Inherited
Matrix metalloproteases, catalytic domain0.3223Inherited
L domain0.3257Inherited
SH3-domain0.3558Inherited
Nuclear receptor ligand-binding domain0.5967Inherited
Nuclear receptor0.5967Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
SMAD MH1 domain0Direct
"Winged helix" DNA-binding domain0.000001104Direct
Notch domain0.00008075Direct
p53-like transcription factors0.0006848Direct
Flavoproteins0.0009474Direct
EGF/Laminin0.00435Inherited
Orange domain-like0.009527Inherited
HLH, helix-loop-helix DNA-binding domain0.01569Inherited
Snake toxin-like0.03471Inherited
Growth factor receptor domain0.039Inherited
Fibronectin type III0.05312Inherited
DBL homology domain (DH-domain)0.05696Inherited
Integrin domains0.1444Inherited
FnI-like domain0.1484Inherited
Hemopexin-like domain0.2031Inherited
PYP-like sensor domain (PAS domain)0.2093Inherited
HMG-box0.2826Inherited
SH3-domain0.2935Inherited
Frizzled cysteine-rich domain0.2994Inherited
PGBD-like0.3065Inherited
Metalloproteases ("zincins"), catalytic domain0.5478Inherited
Nuclear receptor ligand-binding domain0.5722Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.6307Inherited
PH domain-like0.6977Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    49785,57184
  • 49785 - Galactose-binding domain-like
  • 57184 - Growth factor receptor domain
  • 0.0003737Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.000401Direct
    57184,57603
  • 57184 - Growth factor receptor domain
  • 57603 - FnI-like domain
  • 0.0006408Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.0006408Direct
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.009527Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.03134Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.04646Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.08975Inherited
    49854,49854
  • 49854 - Spermadhesin, CUB domain
  • 49854 - Spermadhesin, CUB domain
  • 0.111Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.111Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1444Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.2031Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.3065Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.3113Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.3113Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.3817Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.514Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03471Inherited
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.04036Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.06401Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.07807Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.07807Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.1875Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.3065Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.3113Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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