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Mammalian Phenotype (MP): abnormal cytokine secretion

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + 2:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ 1:   abnormal immune serum protein physiology [MP:0002723] <4>(25|40) (31|24|12)
0:   abnormal cytokine secretion [MP:0003009] <4>(17|33) (23|19|8)
- 1:   abnormal interleukin secretion [MP:0008568] <19>(13|26) (17|15|7)
- 1:   abnormal interferon secretion [MP:0008555] <3>(9|17) (11|11|3)
- 1:   abnormal tumor necrosis factor secretion [MP:0008556] <2>(2|4) (4|3|1)
- 1:   abnormal chemokine secretion [MP:0008722](1|1) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
STAT0.0000009753Direct
Transcription factor STAT-4 N-domain0.0000009753Direct
Toll/Interleukin receptor TIR domain0.0007754Direct
DEATH domain0.002076Inherited
Transducin (alpha subunit), insertion domain0.00671Inherited
RNI-like0.02193Inherited
SH2 domain0.04068Inherited
SH3-domain0.18Inherited
Caspase-like0.2163Inherited
4-helical cytokines0.2658Inherited
DBL homology domain (DH-domain)0.3574Inherited
SMAD/FHA domain0.3574Inherited
TNF receptor-like0.426Inherited
MHC antigen-recognition domain0.522Inherited
L domain-like0.5473Inherited
TNF-like0.6164Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Interleukin 17F, IL-17F0Direct
Caspase recruitment domain, CARD0.00000009005Direct
STAT DNA-binding domain0.0000006271Direct
STAT0.0000006271Direct
Transcription factor STAT-4 N-domain0.0000006271Direct
Interferons/interleukin-10 (IL-10)0.00001474Direct
Interleukin-1 (IL-1)0.00005997Direct
Toll/Interleukin receptor TIR domain0.0007653Direct
Notch domain0.001817Inherited
Transducin (alpha subunit), insertion domain0.005211Inherited
DEATH domain, DD0.01127Inherited
SH2 domain0.03429Inherited
Cell cycle control phosphatase, catalytic domain0.03484Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.04764Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.0676Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.1342Inherited
Pyrin domain, PYD0.1342Inherited
SH3-domain0.1635Inherited
28-residue LRR0.1836Inherited
V set domains (antibody variable domain-like)0.2096Inherited
Interferon regulatory factor0.2393Inherited
Caspase catalytic domain0.2635Inherited
RING finger domain, C3HC40.2735Inherited
EF-hand modules in multidomain proteins0.3107Inherited
DBL homology domain (DH-domain)0.329Inherited
TNF receptor-like0.3369Inherited
PLC-like (P variant)0.3396Inherited
C1 set domains (antibody constant domain-like)0.4054Inherited
MHC antigen-recognition domain0.493Inherited
TNF-like0.5928Inherited
Pleckstrin-homology domain (PH domain)0.8642Inherited
Short-chain cytokines0.9173Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
STAT0.0000003966Direct
Transcription factor STAT-4 N-domain0.0000003966Direct
Toll/Interleukin receptor TIR domain0.0004174Direct
DEATH domain0.001183Inherited
Notch domain0.001484Inherited
Transducin (alpha subunit), insertion domain0.004097Inherited
RNI-like0.01449Inherited
SH2 domain0.02829Inherited
SH3-domain0.1452Inherited
Rhodanese/Cell cycle control phosphatase0.1784Inherited
Caspase-like0.1784Inherited
4-helical cytokines0.2245Inherited
Cystine-knot cytokines0.3008Inherited
SMAD/FHA domain0.3118Inherited
DBL homology domain (DH-domain)0.3118Inherited
TNF receptor-like0.3793Inherited
MHC antigen-recognition domain0.4745Inherited
L domain-like0.5005Inherited
RING/U-box0.547Inherited
TNF-like0.5711Inherited
PH domain-like0.6961Inherited
"Winged helix" DNA-binding domain0.7644Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0000003966Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0000003966Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0000003966Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0001948Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0.0004154Direct
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.0005577Direct
    52821,52799
  • 52821 - Rhodanese/Cell cycle control phosphatase
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.002187Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01503Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.06212Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.126Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.1784Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1944Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.252Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.296Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.3871Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.4464Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.4595Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5987Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0000003966Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0000003966Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.0004154Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01124Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.252Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.4898Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.633Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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