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Mammalian Phenotype (MP): abnormal pancreatic beta cell physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   endocrine/exocrine gland phenotype [MP:0005379] <2>(51|81) (55|36|12)
+ + + 3:   abnormal gland physiology [MP:0002164] <4>(9|19) (11|11|5)
+ + 2:   abnormal pancreas physiology [MP:0002693] <8>(5|12) (5|7|3)
+ + 2:   abnormal endocrine gland physiology [MP:0013561] <6>(4|10) (4|6|2)
+ 1:   abnormal endocrine pancreas physiology [MP:0010147] <6>(3|7) (3|5|2)
0:   abnormal pancreatic beta cell physiology [MP:0003562] <4>(3|7) (3|5|2)
- 1:   abnormal amylin secretion [MP:0014123] <2>(0|0) (0|0|0)
- 1:   abnormal insulin secretion [MP:0003564] <2>(1|4) (1|1|0)
- 1:   abnormal pancreatic beta cell apoptosis [MP:0014116] <2>(0|0) (0|0|0)
- 1:   abnormal pancreatic beta cell proliferation [MP:0011818] <2>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
STAT0.0002344Direct
Transcription factor STAT-4 N-domain0.0002344Direct
Thyroglobulin type-1 domain0.003852Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
STAT DNA-binding domain0.0001383Direct
STAT0.0001383Direct
Transcription factor STAT-4 N-domain0.0001383Direct
Forkhead DNA-binding domain0.0002196Direct
FYVE, a phosphatidylinositol-3-phosphate binding domain0.002038Inherited
Thyroglobulin type-1 domain0.002581Inherited
Growth factor receptor domain0.02842Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
STAT0.0001189Direct
Transcription factor STAT-4 N-domain0.0001189Direct
Thyroglobulin type-1 domain0.002265Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,57610
  • 57184 - Growth factor receptor domain
  • 57610 - Thyroglobulin type-1 domain
  • 0.00005713Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0001189Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0001189Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0001189Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0006158Direct

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0001189Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0001189Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)