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Mammalian Phenotype (MP): abnormal nervous system physiology

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + 2:   mammalian phenotype [MP:0000001] <29>
+ 1:   nervous system phenotype [MP:0003631] <2>(98|128) (113|79|50)
0:   abnormal nervous system physiology [MP:0003633] <38>(43|60) (52|31|18)
- 1:   abnormal neuron physiology [MP:0004811] <12>(8|12) (11|7|5)
- 1:   abnormal synaptic transmission [MP:0003635] <8>(23|28) (27|14|6)
- 1:   abnormal nervous system electrophysiology [MP:0002272] <7>(4|8) (7|3|0)
- 1:   seizures [MP:0002064] <6>(10|15) (13|3|0)
- 1:   abnormal glial cell physiology [MP:0003690] <5>(2|2) (3|0|0)
- 1:   intracranial hemorrhage [MP:0001915] <4>(0|0) (0|1|0)
- 1:   abnormal myelination [MP:0000920] <3>(0|4) (0|2|2)
- 1:   abnormal somatic nervous system physiology [MP:0005423] <3>(0|0) (0|1|0)
- 1:   increased brain apoptosis [MP:0014178] <3>(0|0) (0|0|0)
- 1:   abnormal autonomic nervous system physiology [MP:0006276] <2>(1|1) (1|0|0)
- 1:   abnormal cerebrospinal fluid production [MP:0001911] <2>(0|0) (0|0|0)
- 1:   abnormal dopamine level [MP:0001905] <2>(2|1) (2|1|0)
- 1:   abnormal embryonic neuroepithelial cell proliferation [MP:0012704] <2>(1|1) (1|0|0)
- 1:   abnormal ependyma motile cilium physiology [MP:0011068] <2>(0|0) (0|0|0)
- 1:   abnormal nervous system regeneration [MP:0004858] <2>(2|2) (2|0|0)
- 1:   abnormal neuroendocrine gland physiology [MP:0013570] <2>(0|0) (0|0|0)
- 1:   abnormal sensorimotor gating [MP:0002634] <2>(1|1) (1|0|0)
- 1:   altered response to CNS ischemic injury [MP:0003075] <2>(4|4) (6|1|0)
- 1:   CNS inflammation [MP:0006082] <1>(0|1) (1|0|0)
- 1:   abnormal central pattern generator function [MP:0003880] <1>(1|2) (2|0|0)
- 1:   abnormal endoneurial fluid pressure [MP:0011398] <1>(0|0) (0|0|0)
- 1:   abnormal hypothalamus physiology [MP:0005645] <1>(0|0) (0|0|0)
- 1:   abnormal neuronal stem cell physiology [MP:0012204] <1>(0|0) (0|0|0)
- 1:   abnormal somatosensory cortex physiology [MP:0001908] <1>(0|0) (0|0|0)
- 1:   abnormal synaptic plasticity [MP:0004859] <1>(2|1) (2|1|0)
- 1:   increased neural tube apoptosis [MP:0012505] <1>(0|0) (0|0|0)
- 1:   CNS ischemia [MP:0006080](0|0) (0|0|0)
- 1:   abnormal blood-brain barrier function [MP:0005167](2|0) (2|0|0)
- 1:   abnormal blood-cerebrospinal fluid barrier function [MP:0006088](0|0) (0|0|0)
- 1:   abnormal blood-retinal barrier function [MP:0014179](0|0) (0|0|0)
- 1:   abnormal cerebrospinal fluid flow [MP:0013907](0|0) (0|0|0)
- 1:   abnormal glymphatic system physiology [MP:0020371](0|0) (0|0|0)
- 1:   abnormal hippocampus physiology [MP:0012006](0|0) (0|0|0)
- 1:   decreased hindbrain apoptosis [MP:0012502](0|0) (0|0|0)
- 1:   encephalopathy [MP:0013806](0|0) (0|0|0)
- 1:   endoneurial edema [MP:0011397](0|0) (0|0|0)
- 1:   increased spinal cord apoptosis [MP:0013182](0|0) (0|0|0)
- 1:   spinal hemorrhage [MP:0006054](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Proton glutamate symport protein0Direct
Metallothionein0Direct
Synuclein0Direct
Lamin A/C globular tail domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Voltage-gated potassium channels0.00000006207Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0003905Direct
Nicotinic receptor ligand binding domain-like0.0003905Direct
Periplasmic binding protein-like I0.003677Inherited
Periplasmic binding protein-like II0.01571Inherited
SRF-like0.01719Inherited
Flavoproteins0.03806Inherited
SNARE fusion complex0.04936Inherited
Family A G protein-coupled receptor-like0.05619Inherited
Cysteine-rich domain0.06632Inherited
L27 domain0.07024Inherited
SH3-domain0.08776Inherited
MFS general substrate transporter0.09268Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.09976Inherited
Riboflavin synthase domain-like0.09976Inherited
Toll/Interleukin receptor TIR domain0.1341Inherited
TNF receptor-like0.1452Inherited
PDZ domain-like0.1511Inherited
Caspase-like0.1823Inherited
SNF-like0.1823Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.1955Inherited
Kringle-like0.2546Inherited
PreATP-grasp domain0.3023Inherited
Spermadhesin, CUB domain0.3748Inherited
4-helical cytokines0.4245Inherited
BAR/IMD domain-like0.4259Inherited
Plexin repeat0.4324Inherited
Zn-dependent exopeptidases0.4818Inherited
PLP-dependent transferases0.4818Inherited
alpha/beta-Hydrolases0.536Inherited
HLH, helix-loop-helix DNA-binding domain0.6298Inherited
Sema domain0.6645Inherited
FAD/NAD(P)-binding domain0.6981Inherited
Complement control module/SCR domain0.7527Inherited
Glutathione synthetase ATP-binding domain-like0.7784Inherited
Concanavalin A-like lectins/glucanases0.8126Inherited
L domain-like0.8205Inherited
Homeodomain-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Synapsin C-terminal domain0Direct
Metallothionein0Direct
Retinoblastoma tumor suppressor domains0Direct
Proton glutamate symport protein0Direct
Synapsin domain0Direct
Synuclein0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Lamin A/C globular tail domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Voltage-gated potassium channels0.00007089Direct
Nicotinic receptor ligand binding domain-like0.0002309Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0002309Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.003999Inherited
NADPH-cytochrome p450 reductase-like0.003999Inherited
L-arabinose binding protein-like0.008374Inherited
Phosphate binding protein-like0.01098Inherited
Tetramerization domain of potassium channels0.01166Inherited
SRF-like0.01295Inherited
Synaptotagmin-like (S variant)0.01337Inherited
Pyridoxal-dependent decarboxylase0.01376Inherited
Rhodopsin-like0.01546Inherited
SNARE fusion complex0.03674Inherited
PDZ domain0.04217Inherited
Leucine zipper domain0.05012Inherited
L27 domain0.05392Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.05676Inherited
Acetylcholinesterase-like0.0615Inherited
SH3-domain0.07034Inherited
Cytoplasmic domain of inward rectifier potassium channel0.08799Inherited
TNF receptor-like0.1133Inherited
Ephrin ectodomain0.1141Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.1178Inherited
C1 set domains (antibody constant domain-like)0.1324Inherited
Caspase catalytic domain0.1524Inherited
SNF-like0.1524Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.1646Inherited
L domain0.1646Inherited
Fibronectin type II module0.1646Inherited
Motor proteins0.1874Inherited
Toll/Interleukin receptor TIR domain0.1908Inherited
Actin/HSP700.2459Inherited
Long-chain cytokines0.2721Inherited
BAR domain0.2727Inherited
Spermadhesin, CUB domain0.3621Inherited
Plexin repeat0.3962Inherited
Phosphotyrosine-binding domain (PTB)0.4326Inherited
YWTD domain0.5076Inherited
MAM domain0.5105Inherited
HLH, helix-loop-helix DNA-binding domain0.5989Inherited
Laminin-type module0.6008Inherited
Intermediate filament protein, coiled coil region0.6288Inherited
Sema domain0.6322Inherited
V set domains (antibody variable domain-like)0.6634Inherited
SH2 domain0.713Inherited
G proteins0.7219Inherited
SAM (sterile alpha motif) domain0.7309Inherited
Complement control module/SCR domain0.7491Inherited
Laminin G-like module0.8599Inherited
Ngr ectodomain-like0.9161Inherited
Homeodomain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Lamin A/C globular tail domain0Direct
Metallothionein0Direct
Proton glutamate symport protein0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Synuclein0Direct
Voltage-gated potassium channels0.00000002417Direct
Nicotinic receptor ligand binding domain-like0.0002039Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0002039Direct
Periplasmic binding protein-like I0.002158Inherited
Periplasmic binding protein-like II0.01012Inherited
SRF-like0.01117Inherited
Flavoproteins0.02631Inherited
SNARE fusion complex0.03483Inherited
Leucine zipper domain0.03802Inherited
Family A G protein-coupled receptor-like0.04014Inherited
Cysteine-rich domain0.04821Inherited
L27 domain0.05137Inherited
SH3-domain0.06543Inherited
MFS general substrate transporter0.06945Inherited
Riboflavin synthase domain-like0.07524Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.07524Inherited
Toll/Interleukin receptor TIR domain0.1048Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.1062Inherited
TNF receptor-like0.1144Inherited
PDZ domain-like0.1198Inherited
Caspase-like0.1473Inherited
Cupredoxins0.1473Inherited
SNF-like0.1473Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.1592Inherited
Kringle-like0.2139Inherited
PreATP-grasp domain0.2589Inherited
Spermadhesin, CUB domain0.3289Inherited
4-helical cytokines0.3777Inherited
BAR/IMD domain-like0.3791Inherited
Plexin repeat0.3854Inherited
Zn-dependent exopeptidases0.4341Inherited
PLP-dependent transferases0.4341Inherited
Nuclear receptor ligand-binding domain0.4836Inherited
alpha/beta-Hydrolases0.4889Inherited
YWTD domain0.4977Inherited
GTPase activation domain, GAP0.5064Inherited
HLH, helix-loop-helix DNA-binding domain0.5853Inherited
Intermediate filament protein, coiled coil region0.5856Inherited
Sema domain0.622Inherited
SH2 domain0.6549Inherited
FAD/NAD(P)-binding domain0.657Inherited
Complement control module/SCR domain0.7146Inherited
Glutathione synthetase ATP-binding domain-like0.742Inherited
Concanavalin A-like lectins/glucanases0.7785Inherited
L domain-like0.7871Inherited
EGF/Laminin0.9444Inherited
Homeodomain-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,56496
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0Direct
    56496,49899
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    49785,49899
  • 49785 - Galactose-binding domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.0002039Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.000944Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.001241Inherited
    81324,81324
  • 81324 - Voltage-gated potassium channels
  • 81324 - Voltage-gated potassium channels
  • 0.00994Inherited
    57535,49854
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0.01117Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.07524Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.07667Inherited
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.07667Inherited
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.1062Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.151Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.1592Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.1592Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.1592Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1651Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.2047Inherited
    48726,82895
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 0.2303Inherited
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.2647Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.403Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.4618Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.525Inherited
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.622Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.7406Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.9952Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    56496,49899,49899
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    49785,49899,49899
  • 49785 - Galactose-binding domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    49899,57196,56496
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 0Direct
    57196,56496,49899
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    75399,75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    49854,57535,49854
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0.01117Inherited
    57535,49854,57535
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.01117Inherited
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.06543Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.1592Inherited
    101288,50156,50044
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0.2303Inherited
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.2303Inherited
    48726,48726,82895
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 0.2303Inherited
    48726,82895,82895
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.2303Inherited
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.2647Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.5903Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.6679Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.9665Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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