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Mammalian Phenotype (MP): abnormal synaptic transmission

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   nervous system phenotype [MP:0003631] <2>(98|128) (113|79|50)
+ 1:   abnormal nervous system physiology [MP:0003633] <38>(43|60) (52|31|18)
0:   abnormal synaptic transmission [MP:0003635] <8>(23|28) (27|14|6)
- 1:   abnormal CNS synaptic transmission [MP:0002206] <14>(18|21) (24|14|6)
- 1:   abnormal neurotransmitter secretion [MP:0005445] <7>(1|3) (1|1|1)
- 1:   abnormal PNS synaptic transmission [MP:0002913] <2>(2|4) (3|1|0)
- 1:   abnormal channel response [MP:0003484] <2>(1|2) (1|0|0)
- 1:   abnormal paired-pulse facilitation [MP:0002918] <2>(2|4) (2|1|0)
- 1:   abnormal neurotransmitter level [MP:0002204](1|1) (1|0|0)
- 1:   abnormal neurotransmitter uptake [MP:0003444](1|0) (1|0|0)
- 1:   abnormal paired-pulse inhibition [MP:0004807](1|1) (1|1|1)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Periplasmic binding protein-like II0.000000000007886Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000001657Direct
Nicotinic receptor ligand binding domain-like0.000001657Direct
PDZ domain-like0.000003806Direct
Periplasmic binding protein-like I0.00001353Direct
SRF-like0.001023Inherited
SNF-like0.01355Inherited
Cysteine-rich domain0.0292Inherited
Voltage-gated potassium channels0.03667Inherited
BAR/IMD domain-like0.0388Inherited
PreATP-grasp domain0.04099Inherited
SNARE fusion complex0.04398Inherited
Zn-dependent exopeptidases0.0568Inherited
Complement control module/SCR domain0.08901Inherited
PLP-dependent transferases0.1046Inherited
SH3-domain0.1526Inherited
Glutathione synthetase ATP-binding domain-like0.2115Inherited
L27 domain0.2235Inherited
MFS general substrate transporter0.2641Inherited
Spermadhesin, CUB domain0.3173Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.335Inherited
Riboflavin synthase domain-like0.335Inherited
Concanavalin A-like lectins/glucanases0.3738Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Synapsin C-terminal domain0Direct
Synapsin domain0Direct
Phosphate binding protein-like0.0000000000004222Direct
Nicotinic receptor ligand binding domain-like0.000001145Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000001145Direct
PDZ domain0.00003385Direct
L-arabinose binding protein-like0.0001357Direct
Pyridoxal-dependent decarboxylase0.0003908Direct
SRF-like0.0006978Direct
Synaptotagmin-like (S variant)0.004642Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.008499Inherited
SNF-like0.009931Inherited
SNARE fusion complex0.03438Inherited
Ephrin ectodomain0.03929Inherited
BAR domain0.04867Inherited
Phosphotyrosine-binding domain (PTB)0.0534Inherited
Complement control module/SCR domain0.08106Inherited
Laminin G-like module0.09169Inherited
YWTD domain0.1082Inherited
SH3-domain0.1414Inherited
G proteins0.164Inherited
Acetylcholinesterase-like0.1839Inherited
C1 set domains (antibody constant domain-like)0.1981Inherited
L27 domain0.1981Inherited
SAM (sterile alpha motif) domain0.2253Inherited
Spermadhesin, CUB domain0.2908Inherited
Voltage-gated potassium channels0.2926Inherited
Tetramerization domain of potassium channels0.4047Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Periplasmic binding protein-like II0.000000000002859Direct
Nicotinic receptor ligand binding domain-like0.0000006804Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000006804Direct
PDZ domain-like0.00000162Direct
Periplasmic binding protein-like I0.000005991Direct
SRF-like0.0005591Direct
SNF-like0.008644Inherited
Cysteine-rich domain0.01979Inherited
Voltage-gated potassium channels0.02525Inherited
BAR/IMD domain-like0.02685Inherited
PreATP-grasp domain0.0285Inherited
SNARE fusion complex0.03073Inherited
Nuclear receptor ligand-binding domain0.03788Inherited
Zn-dependent exopeptidases0.04064Inherited
Complement control module/SCR domain0.06648Inherited
PLP-dependent transferases0.07938Inherited
YWTD domain0.09991Inherited
SH3-domain0.121Inherited
Glutathione synthetase ATP-binding domain-like0.1737Inherited
Cupredoxins0.1851Inherited
L27 domain0.1851Inherited
MFS general substrate transporter0.2228Inherited
Spermadhesin, CUB domain0.2732Inherited
Riboflavin synthase domain-like0.2901Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2901Inherited
Concanavalin A-like lectins/glucanases0.3278Inherited
alpha/beta-Hydrolases0.5041Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.0000006804Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.000007261Direct
    57535,49854
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0.0005591Direct
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.008457Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.02048Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.02834Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.03073Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.05232Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.09991Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1301Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.2627Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    49854,57535,49854
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0.0005591Direct
    57535,49854,57535
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.0005591Direct
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.004563Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.03571Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1376Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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