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Mammalian Phenotype (MP): abnormal bone structure

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   skeleton phenotype [MP:0005390] <2>(46|63) (50|41|26)
+ 1:   abnormal skeleton morphology [MP:0005508] <15>(41|59) (47|38|25)
0:   abnormal bone structure [MP:0003795] <17>(17|23) (22|14|6)
- 1:   abnormal compact bone morphology [MP:0003797] <6>(6|5) (7|1|0)
- 1:   abnormal trabecular bone morphology [MP:0000130] <6>(8|13) (9|2|0)
- 1:   abnormal bone mineral density [MP:0010119] <5>(2|4) (4|0|0)
- 1:   abnormal bone volume [MP:0010874] <4>(3|4) (3|3|1)
- 1:   abnormal osteoblast morphology [MP:0004986] <3>(2|1) (3|0|0)
- 1:   abnormal periosteum morphology [MP:0010971] <3>(0|0) (0|0|0)
- 1:   decreased bone mass [MP:0004016] <3>(3|3) (3|1|0)
- 1:   increased bone mass [MP:0005605] <3>(0|3) (1|1|0)
- 1:   abnormal bone mineral content [MP:0010122] <2>(1|1) (1|0|0)
- 1:   abnormal osteoclast morphology [MP:0004982] <2>(4|7) (6|1|0)
- 1:   altered susceptibility to osteoporosis [MP:0012070] <2>(0|0) (0|0|0)
- 1:   abnormal bone marrow cavity morphology [MP:0000065] <1>(0|0) (0|1|0)
- 1:   abnormal bone marrow morphology [MP:0002397] <1>(0|0) (0|0|0)
- 1:   abnormal bone collagen fibril morphology [MP:0011642](0|0) (0|0|0)
- 1:   exostosis [MP:0009877](0|0) (0|0|0)
- 1:   osteophytes [MP:0013304](1|1) (1|0|0)
- 1:   osteosclerosis [MP:0005422](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
TNF receptor-like0.0008178Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.01741Inherited
Riboflavin synthase domain-like0.01741Inherited
Flavoproteins0.01773Inherited
Nuclear receptor ligand-binding domain0.03859Inherited
PYP-like sensor domain (PAS domain)0.04202Inherited
Hect, E3 ligase catalytic domain0.05873Inherited
GLA-domain0.07132Inherited
PGBD-like0.1101Inherited
Hemopexin-like domain0.2006Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.2896Inherited
Spermadhesin, CUB domain0.31Inherited
L domain-like0.364Inherited
FnI-like domain0.4009Inherited
TSP-1 type 1 repeat0.4055Inherited
EGF/Laminin0.5793Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
TNF receptor-like0.00007264Direct
beta-glycanases0.000903Direct
Cytochrome p450 reductase N-terminal domain-like0.000903Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.003157Inherited
NADPH-cytochrome p450 reductase-like0.003157Inherited
Nuclear receptor ligand-binding domain0.02705Inherited
Nuclear receptor0.02705Inherited
Hect, E3 ligase catalytic domain0.04294Inherited
GLA-domain0.05349Inherited
MMP N-terminal domain0.08607Inherited
Matrix metalloproteases, catalytic domain0.08607Inherited
Long-chain cytokines0.1034Inherited
Hemopexin-like domain0.1664Inherited
Kringle modules0.2257Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.249Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.249Inherited
Spermadhesin, CUB domain0.2688Inherited
Ngr ectodomain-like0.2736Inherited
EGF-type module0.3197Inherited
Growth factor receptor domain0.3253Inherited
TSP-1 type 1 repeat0.3618Inherited
VWC domain0.4826Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
TNF receptor-like0.0004419Direct
Riboflavin synthase domain-like0.01134Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.01134Inherited
Flavoproteins0.01155Inherited
Nuclear receptor ligand-binding domain0.02669Inherited
PYP-like sensor domain (PAS domain)0.02929Inherited
Hect, E3 ligase catalytic domain0.04216Inherited
GLA-domain0.05226Inherited
4-helical cytokines0.0813Inherited
PGBD-like0.08418Inherited
TNF-like0.1185Inherited
Hemopexin-like domain0.1638Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.247Inherited
Kringle-like0.259Inherited
Spermadhesin, CUB domain0.2662Inherited
L domain-like0.3184Inherited
FnI-like domain0.3541Inherited
TSP-1 type 1 repeat0.3586Inherited
Frizzled cysteine-rich domain0.4785Inherited
Growth factor receptor domain0.5307Inherited
EGF/Laminin0.5329Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    49265,53300
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.00001328Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0004066Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.0004702Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0004702Direct
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.0008049Direct
    53300,49265
  • 53300 - vWA-like
  • 49265 - Fibronectin type III
  • 0.0008049Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.03377Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.08418Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.08578Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1385Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.2226Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.246Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49265,49265,53300
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0001088Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0001088Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.0008049Direct
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.2226Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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