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Mammalian Phenotype (MP): abnormal nervous system development

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   mammalian phenotype [MP:0000001] <29>
+ + 2:   nervous system phenotype [MP:0003631] <2>(98|128) (113|79|50)
+ 1:   abnormal nervous system morphology [MP:0003632] <17>(76|104) (91|64|47)
0:   abnormal nervous system development [MP:0003861] <9>(19|31) (21|14|10)
- 1:   abnormal neural tube morphology [MP:0002151] <16>(7|8) (7|4|3)
- 1:   abnormal brain development [MP:0000913] <15>(6|12) (7|4|1)
- 1:   abnormal neuron differentiation [MP:0009937] <8>(8|11) (8|2|1)
- 1:   abnormal CNS synapse formation [MP:0004996] <3>(1|1) (1|1|1)
- 1:   abnormal embryonic/fetal subventricular zone morphology [MP:0004274] <3>(0|0) (1|1|0)
- 1:   abnormal neural plate morphology [MP:0005657] <1>(0|0) (0|0|0)
- 1:   abnormal vestibulocochlear ganglion morphology [MP:0003703] <1>(0|0) (0|0|0)
- 1:   anencephaly [MP:0001890] <1>(0|0) (0|0|0)
- 1:   abnormal neuronal stem cell morphology [MP:0012203](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Growth factor receptor domain0.00005055Direct
SMAD MH1 domain0.0001857Direct
HLH, helix-loop-helix DNA-binding domain0.000952Direct
HCP-like0.008398Inherited
EGF/Laminin0.01067Inherited
Homeodomain-like0.01744Inherited
Bromodomain0.02655Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.02808Inherited
Frizzled cysteine-rich domain0.04468Inherited
Galactose-binding domain-like0.1396Inherited
Fibronectin type III0.1589Inherited
TIMP-like0.259Inherited
Concanavalin A-like lectins/glucanases0.3725Inherited
SAM/Pointed domain0.4095Inherited
SNARE fusion complex0.4499Inherited
RNA-binding domain, RBD0.8892Inherited
PDZ domain-like0.8992Inherited
Family A G protein-coupled receptor-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Other IPT/TIG domains0Direct
Synapsin C-terminal domain0Direct
Synapsin domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
SMAD MH1 domain0.0001253Direct
SMAD domain0.0001253Direct
DIX domain0.0001256Direct
L domain0.0005845Direct
Growth factor receptor domain0.0006097Direct
HLH, helix-loop-helix DNA-binding domain0.0006312Direct
Formate/glycerate dehydrogenases, substrate-binding domain0.00323Inherited
Mib/herc2 domain0.00323Inherited
Classic zinc finger, C2H20.005626Inherited
Ephrin receptor ligand binding domain0.01195Inherited
Formate/glycerate dehydrogenases, NAD-domain0.02196Inherited
Bromodomain0.02285Inherited
Frizzled cysteine-rich domain0.03388Inherited
Homeodomain0.06413Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.06692Inherited
Cyclin0.06822Inherited
Laminin G-like module0.07384Inherited
SAM (sterile alpha motif) domain0.09118Inherited
Fibronectin type III0.1384Inherited
Forkhead DNA-binding domain0.2739Inherited
DEP domain0.2939Inherited
POU-specific domain0.3139Inherited
SNARE fusion complex0.4136Inherited
Phosphotyrosine-binding domain (PTB)0.6999Inherited
PDZ domain0.795Inherited
Canonical RBD0.8573Inherited
Rhodopsin-like1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Growth factor receptor domain0.00002377Direct
SMAD MH1 domain0.00009346Direct
HLH, helix-loop-helix DNA-binding domain0.0005178Direct
Mib/herc2 domain-like0.0027Inherited
HCP-like0.005183Inherited
EGF/Laminin0.006691Inherited
Homeodomain-like0.01137Inherited
Bromodomain0.01783Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.01897Inherited
Frizzled cysteine-rich domain0.03127Inherited
Galactose-binding domain-like0.1095Inherited
Fibronectin type III0.1266Inherited
TIMP-like0.2181Inherited
Concanavalin A-like lectins/glucanases0.3266Inherited
SAM/Pointed domain0.3628Inherited
SNARE fusion complex0.4022Inherited
lambda repressor-like DNA-binding domains0.5141Inherited
RNA-binding domain, RBD0.8614Inherited
PDZ domain-like0.8721Inherited
Family A G protein-coupled receptor-like0.9998Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0004593Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0004593Direct
    48452,81901
  • 48452 - TPR-like
  • 81901 - HCP-like
  • 0.0027Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.006835Inherited
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.01093Inherited
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.01897Inherited
    57196,49899
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.06337Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.1112Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.2673Inherited
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0.4022Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.4148Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.5222Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.604Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0004593Direct
    48065,50729,50044
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.0005267Direct
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.005983Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.09887Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1835Inherited
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.2524Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.3847Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.4148Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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