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Mammalian Phenotype (MP): abnormal lymphocyte physiology

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   mammalian phenotype [MP:0000001] <29>
+ + + + 4:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + 4:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + 3:   abnormal immune system physiology [MP:0001790] <16>(59|84) (66|49|28)
+ + + 3:   abnormal hematopoietic system physiology [MP:0001545] <5>(39|53) (40|38|21)
+ + 2:   abnormal cell-mediated immunity [MP:0002421] <3>(35|48) (37|33|21)
+ + 2:   abnormal blood cell physiology [MP:0012382] <3>(38|53) (39|38|21)
+ + 2:   abnormal adaptive immunity [MP:0002420] <8>(36|48) (38|33|21)
+ + 2:   abnormal immune cell physiology [MP:0001819] <3>(35|48) (37|33|21)
+ 1:   abnormal leukocyte physiology [MP:0002442] <5>(34|48) (36|33|20)
0:   abnormal lymphocyte physiology [MP:0003945] <4>(21|31) (23|22|13)
- 1:   abnormal B cell physiology [MP:0002459] <9>(19|27) (20|16|10)
- 1:   abnormal T cell physiology [MP:0002444] <7>(8|15) (11|16|7)
- 1:   abnormal NK cell physiology [MP:0010766] <2>(7|5) (7|5|3)
- 1:   abnormal lymphocyte activation involved in immune response [MP:0020191] <2>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
TNF receptor-like0.0000000005191Direct
MHC antigen-recognition domain0.00000006562Direct
Caspase-like0.000002003Direct
Inhibitor of apoptosis (IAP) repeat0.0004796Direct
p53-like transcription factors0.01033Inherited
E set domains0.01593Inherited
SH2 domain0.02779Inherited
SMAD/FHA domain0.03416Inherited
WWE domain0.03457Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.03824Inherited
L30e-like0.05226Inherited
TNF-like0.05642Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.1156Inherited
SH3-domain0.223Inherited
4-helical cytokines0.2321Inherited
Bcl-2 inhibitors of programmed cell death0.3267Inherited
DBL homology domain (DH-domain)0.6014Inherited
Toll/Interleukin receptor TIR domain0.6487Inherited
Family A G protein-coupled receptor-like0.9935Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
STAT DNA-binding domain0Direct
STAT0Direct
Proteasome subunits0Direct
Transcription factor STAT-4 N-domain0Direct
TNF receptor-like0.0000000007938Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00000003139Direct
MHC antigen-recognition domain0.00000004831Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0000008399Direct
Caspase catalytic domain0.000007488Direct
Inhibitor of apoptosis (IAP) repeat0.00006638Direct
Interferon regulatory factor0.0002008Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0005249Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0.003973Inherited
Interleukin 17F, IL-17F0.007192Inherited
WWE domain0.01545Inherited
SH2 domain0.02206Inherited
TNF-like0.04415Inherited
C1 set domains (antibody constant domain-like)0.04415Inherited
PLC-like (P variant)0.04415Inherited
DEATH domain, DD0.05481Inherited
Pleckstrin-homology domain (PH domain)0.07446Inherited
V set domains (antibody variable domain-like)0.1066Inherited
SH3-domain0.2033Inherited
I set domains0.2089Inherited
FHA domain0.2205Inherited
ets domain0.2381Inherited
Bcl-2 inhibitors of programmed cell death0.2934Inherited
Caspase recruitment domain, CARD0.3132Inherited
Short-chain cytokines0.3652Inherited
DBL homology domain (DH-domain)0.5736Inherited
Toll/Interleukin receptor TIR domain0.6709Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
STAT0Direct
Transcription factor STAT-4 N-domain0Direct
TNF receptor-like0.0000000001906Direct
MHC antigen-recognition domain0.00000002564Direct
Caspase-like0.0000008281Direct
Inhibitor of apoptosis (IAP) repeat0.0002526Direct
p53-like transcription factors0.006462Inherited
E set domains0.01028Inherited
SH2 domain0.01874Inherited
SMAD/FHA domain0.02345Inherited
WWE domain0.02375Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.02644Inherited
L30e-like0.03703Inherited
TNF-like0.04033Inherited
Transducin (alpha subunit), insertion domain0.07807Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.08891Inherited
SH3-domain0.1846Inherited
4-helical cytokines0.193Inherited
Bcl-2 inhibitors of programmed cell death0.2823Inherited
DBL homology domain (DH-domain)0.5558Inherited
Toll/Interleukin receptor TIR domain0.6052Inherited
DEATH domain0.6174Inherited
Family A G protein-coupled receptor-like0.979Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0Direct
    47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00000001855Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.00000002388Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0000002807Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.00005074Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.00005074Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.00005074Direct
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.0001531Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.001664Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.006151Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.006602Inherited
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.01331Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.04546Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.06273Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.3382Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.467Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5558Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.6105Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0Direct
    50044,55550,50044
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0003188Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.001823Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.001823Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.006151Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.006602Inherited
    49265,49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.2823Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.5535Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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