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Mammalian Phenotype (MP): abnormal circulating lipid level

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   mammalian phenotype [MP:0000001] <29>
+ + + 3:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + 2:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ + 2:   abnormal lipid homeostasis [MP:0002118] <9>(25|29) (29|17|10)
+ 1:   abnormal blood homeostasis [MP:0009642] <23>(63|82) (70|45|21)
+ 1:   abnormal lipid level [MP:0001547] <16>(24|28) (26|16|10)
0:   abnormal circulating lipid level [MP:0003949] <9>(16|23) (19|13|10)
- 1:   abnormal circulating cholesterol level [MP:0000180] <4>(9|12) (11|9|8)
- 1:   abnormal circulating glucocorticoid level [MP:0003366] <4>(1|1) (1|0|0)
- 1:   abnormal circulating phospholipid level [MP:0006084] <4>(2|1) (2|1|0)
- 1:   abnormal circulating mineralocorticoid level [MP:0003372] <3>(1|1) (1|0|0)
- 1:   abnormal circulating free fatty acids level [MP:0001553] <2>(0|0) (0|0|0)
- 1:   abnormal circulating glycerol level [MP:0011973] <2>(2|1) (2|0|0)
- 1:   abnormal circulating triglyceride level [MP:0011969] <2>(6|11) (6|8|5)
- 1:   abnormal circulating phytosterol level [MP:0010075] <1>(0|1) (1|0|0)
- 1:   hyperlipidemia [MP:0001548](0|1) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Nuclear receptor ligand-binding domain0.00009289Direct
Apolipoprotein A-I0.0002003Direct
Multidrug efflux transporter AcrB transmembrane domain0.004095Inherited
Flavoproteins0.006042Inherited
alpha/beta-Hydrolases0.008788Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.02054Inherited
Riboflavin synthase domain-like0.02054Inherited
YWTD domain0.02054Inherited
Serum albumin-like0.03781Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.04201Inherited
Aquaporin-like0.04512Inherited
Cytochrome P4500.05467Inherited
STAT0.1657Inherited
Transcription factor STAT-4 N-domain0.1657Inherited
Family A G protein-coupled receptor-like0.2061Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Apolipoprotein A-I0Direct
Nuclear receptor ligand-binding domain0.0000398Direct
Pancreatic lipase, N-terminal domain0.00007455Direct
Nuclear receptor0.00009109Direct
CAD domain0.002941Inherited
Sir2 family of transcriptional regulators0.003635Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.009915Inherited
NADPH-cytochrome p450 reductase-like0.009915Inherited
Fatty acid binding protein-like0.0134Inherited
YWTD domain0.0134Inherited
Serum albumin-like0.02603Inherited
Aquaporin-like0.03104Inherited
Cytochrome P4500.03713Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.06553Inherited
STAT DNA-binding domain0.1314Inherited
STAT0.1314Inherited
Transcription factor STAT-4 N-domain0.1314Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.1825Inherited
Rhodopsin-like0.2201Inherited
EGF-type module0.6109Inherited
ABC transporter ATPase domain-like0.6166Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Nuclear receptor ligand-binding domain0.0000446Direct
Apolipoprotein A-I0.0001013Direct
Multidrug efflux transporter AcrB transmembrane domain0.002418Inherited
DHS-like NAD/FAD-binding domain0.003653Inherited
Flavoproteins0.003653Inherited
alpha/beta-Hydrolases0.005433Inherited
Riboflavin synthase domain-like0.01351Inherited
YWTD domain0.01351Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.01351Inherited
Lipocalins0.01438Inherited
Serum albumin-like0.02613Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.02928Inherited
Aquaporin-like0.03163Inherited
Cytochrome P4500.03893Inherited
STAT0.1324Inherited
Transcription factor STAT-4 N-domain0.1324Inherited
Family A G protein-coupled receptor-like0.1688Inherited
P-loop containing nucleoside triphosphate hydrolases0.9768Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0.0001013Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0005655Direct
    48552,48552
  • 48552 - Serum albumin-like
  • 48552 - Serum albumin-like
  • 0.02613Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.02928Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.03178Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.06635Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.07152Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.1119Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.1324Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.1324Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.1324Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.1324Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.01444Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.02613Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.06635Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.07152Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.07152Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.07152Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.1324Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.1324Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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