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Mammalian Phenotype (MP): increased cholesterol level

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + 7:   mammalian phenotype [MP:0000001] <29>
+ + + + + 5:   homeostasis/metabolism phenotype [MP:0005376] <7>(140|174) (149|96|44)
+ + + + 4:   abnormal homeostasis [MP:0001764] <27>(103|129) (113|73|31)
+ + + 3:   abnormal lipid homeostasis [MP:0002118] <9>(25|29) (29|17|10)
+ + + 3:   abnormal lipid level [MP:0001547] <16>(24|28) (26|16|10)
+ + 2:   abnormal cholesterol homeostasis [MP:0005278] <1>(11|12) (13|10|8)
+ + 2:   abnormal sterol level [MP:0012224] <5>(11|13) (14|10|8)
+ 1:   abnormal cholesterol level [MP:0003947] <5>(11|12) (13|10|8)
+ 1:   increased sterol level [MP:0012226] <3>(5|7) (6|5|6)
0:   increased cholesterol level [MP:0003982] <3>(5|7) (6|5|6)
- 1:   increased circulating cholesterol level [MP:0005178] <3>(5|7) (6|5|6)
- 1:   increased brain cholesterol level [MP:0010162](0|0) (0|0|0)
- 1:   increased liver cholesterol level [MP:0010027](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
YWTD domain0.0001147Direct
Riboflavin synthase domain-like0.2244Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.2244Inherited
Flavoproteins0.2244Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
YWTD domain0.00006984Direct
Sir2 family of transcriptional regulators0.0005492Direct
NADPH-cytochrome p450 reductase-like0.1918Inherited
Pancreatic lipase, N-terminal domain0.1918Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.1918Inherited
Cytochrome p450 reductase N-terminal domain-like0.1918Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
YWTD domain0.00005611Direct
DHS-like NAD/FAD-binding domain0.001302Inherited
Riboflavin synthase domain-like0.1859Inherited
Flavoproteins0.1859Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1859Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.00007527Direct
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.0004728Direct
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.0004728Direct
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0.1859Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.0002355Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0002355Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.0002355Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.0002355Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)