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Mammalian Phenotype (MP): decreased lymphocyte cell number

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + 7:   mammalian phenotype [MP:0000001] <29>
+ + + + + + 6:   hematopoietic system phenotype [MP:0005397] <2>(72|102) (78|63|30)
+ + + + + + 6:   immune system phenotype [MP:0005387] <2>(76|114) (86|66|35)
+ + + + + 5:   abnormal immune system morphology [MP:0000685] <3>(50|76) (60|35|18)
+ + + + + 5:   abnormal hematopoietic system morphology/development [MP:0002396] <5>(57|86) (66|47|21)
+ + + + 4:   abnormal immune system cell morphology [MP:0000716] <5>(37|63) (48|29|16)
+ + + + 4:   abnormal hematopoietic cell morphology [MP:0013656] <9>(48|77) (60|43|18)
+ + + 3:   abnormal leukocyte morphology [MP:0008246] <4>(36|62) (47|29|15)
+ + + 3:   abnormal mononuclear cell morphology [MP:0008247] <2>(33|57) (41|28|14)
+ + + 3:   abnormal hematopoietic cell number [MP:0011180] <7>(34|57) (43|29|13)
+ + 2:   decreased hematopoietic cell number [MP:0011182] <5>(21|34) (27|21|11)
+ + 2:   abnormal leukocyte cell number [MP:0000217] <8>(29|49) (37|25|12)
+ + 2:   abnormal lymphocyte morphology [MP:0002619] <5>(27|46) (33|26|14)
+ 1:   abnormal lymphocyte cell number [MP:0000717] <6>(18|38) (25|21|9)
+ 1:   decreased leukocyte cell number [MP:0000221] <5>(17|28) (24|18|10)
0:   decreased lymphocyte cell number [MP:0005016] <5>(16|28) (22|16|7)
- 1:   decreased T cell number [MP:0005018] <12>(8|15) (13|11|5)
- 1:   decreased NK cell number [MP:0008045] <6>(0|0) (0|0|0)
- 1:   decreased B cell number [MP:0005017] <4>(6|11) (7|6|4)
- 1:   absent lymphocyte [MP:0000726] <3>(0|1) (0|0|0)
- 1:   decreased large unstained cell number [MP:0012361](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
SPOC domain-like0Direct
PsbU/PolX domain-like0Direct
DNA polymerase beta, N-terminal domain-like0.0004631Direct
Bcl-2 inhibitors of programmed cell death0.002182Inherited
Integrin alpha N-terminal domain0.006779Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.006894Inherited
WWE domain0.02932Inherited
SH2 domain0.03772Inherited
Integrin domains0.08428Inherited
Cysteine-rich domain0.09308Inherited
Ran binding protein zinc finger-like0.1402Inherited
DBL homology domain (DH-domain)0.1756Inherited
Calponin-homology domain, CH-domain0.3176Inherited
E2F-DP heterodimerization region0.3796Inherited
MHC antigen-recognition domain0.5017Inherited
DEATH domain0.7302Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
RUNT domain0Direct
Proteasome subunits0Direct
DNA polymerase beta-like, second domain0Direct
DNA polymerase beta-like0Direct
Rel/Dorsal transcription factors, DNA-binding domain0.000001071Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.000007533Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.00003792Direct
Pointed domain0.000236Direct
DNA polymerase beta, N-terminal domain-like0.0003028Direct
Bcl-2 inhibitors of programmed cell death0.001557Inherited
Interferon regulatory factor0.001557Inherited
WWE domain0.01296Inherited
Interferon regulatory factor 3 (IRF3), transactivation domain0.02291Inherited
SH2 domain0.03652Inherited
PLC-like (P variant)0.04144Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.05462Inherited
Integrin domains0.07196Inherited
Pleckstrin-homology domain (PH domain)0.0728Inherited
SH3-domain0.09041Inherited
Ran binding protein zinc finger-like0.1231Inherited
DBL homology domain (DH-domain)0.1598Inherited
C1 set domains (antibody constant domain-like)0.2524Inherited
Calponin-homology domain, CH-domain0.298Inherited
Cell cycle transcription factor e2f-dp0.3543Inherited
E2F dimerization segment0.3543Inherited
ets domain0.3559Inherited
MHC antigen-recognition domain0.4862Inherited
Toll/Interleukin receptor TIR domain0.4862Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
PsbU/PolX domain-like0Direct
SPOC domain-like0Direct
DNA polymerase beta, N-terminal domain-like0.0002432Direct
Bcl-2 inhibitors of programmed cell death0.001245Inherited
beta-beta-alpha zinc fingers0.00364Inherited
Integrin alpha N-terminal domain0.004143Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.004215Inherited
p53-like transcription factors0.01515Inherited
WWE domain0.0199Inherited
SH2 domain0.02606Inherited
Integrin domains0.06253Inherited
Cysteine-rich domain0.06975Inherited
SH3-domain0.07008Inherited
Ran binding protein zinc finger-like0.11Inherited
DBL homology domain (DH-domain)0.1412Inherited
Calponin-homology domain, CH-domain0.2735Inherited
E2F-DP heterodimerization region0.3335Inherited
Protein kinase-like (PK-like)0.3855Inherited
Toll/Interleukin receptor TIR domain0.3863Inherited
Acyl-CoA N-acyltransferases (Nat)0.4461Inherited
MHC antigen-recognition domain0.454Inherited
DEATH domain0.6912Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47576,48065
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0Direct
    47802,81585
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 0Direct
    81585,81301
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0000006741Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0000307Direct
    50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0.001006Inherited
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.003226Inherited
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.003226Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.004493Inherited
    53300,69318
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 0.03126Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.1026Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.1412Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.1921Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.1921Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.3335Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.454Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47802,81585,81301
  • 47802 - DNA polymerase beta, N-terminal domain-like
  • 81585 - PsbU/PolX domain-like
  • 81301 - Nucleotidyltransferase
  • 0Direct
    50729,50044,55550
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0Direct
    47576,48065,50729
  • 47576 - Calponin-homology domain, CH-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0Direct
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0.00148Inherited
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.00148Inherited
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.003226Inherited
    53300,69318,69179
  • 53300 - vWA-like
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.03126Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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